A dissertation submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Master of Science. / The ‘Makapan Mummy’ (A1081), the Makapan Child and human and animal remains with desiccated tissue attached indicate that the environment inside Historic Cave was dry enough to cause mummification. Environmental studies conducted in 1992 and 2011 suggest that dry air in the well-ventilated cave preserved the soft tissue and mummified the corpse. The aim of this study is to examine desiccated tissue sampled from the ‘Makapan Mummy’ (A1081) and from the human remains excavated at Historic Cave using scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS) and light microscopy. The morphological features of the naturally desiccated tissue from Historic Cave were recorded and described using the microscopic analyses and were then compared to normal and mummified human tissue. Mummified tissue is hard and dry and often embedded with dust and debris. In its hard and dry state, mummified tissue needs to be prepared differently to normal human tissue. In this study, various methods used to clean, rehydrate and stain the desiccated tissue were investigated and compared. Through this comparative analysis it was possible to determine the most suitable method for examining desiccated tissue from Historic Cave. In the SEM analysis, epidermal keratinocytes and vellus hairs were observed on the surface of the skin tissue. Histological analyses demonstrated the exclusive preservation of collagen fibres in the muscle tissue, the connective tissue and the skin tissue. This suggests that the collagen fibres play an integral part in preserving the structure of desiccated tissue that is devoid of cellular elements. The results are consistent with the histology of desiccated tissue remains from the Republic of Korea, Egypt and the Americas.