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The objective of this research was to compare the skeletal muscle fiber composition in selected isogenic strains of mice. Six strains of mice were surveyed, one male and one female from each strain. The gastrocnemius and quadriceps muscles were stained for oxidative and glycolytic activities as well as contractile properties by using five histochemical stains. These results indicated that both muscles were composed predominantly of fast glycolytic (FG) and fast oxidativeglycolytic (FOG) fibers. There were few slow oxidative (SO) fibers which were mostly confined to the red portion of each muscle, although in some mice (0113 C57BL/6J black male, 0119 DBA/2J dilute brown female, and 0105 BALB/cJ albino male and female) this fiber type seemed to be lacking completely in one or both muscles surveyed. In addition, it was found through 2 the use of planimetry, that SO fibers (-x = 1140.97 μ2) were significantly smaller (P<0.01) than the FOG and FG fibers (-x = 1514.08μ2).Within the limits of these observations it is concluded that further examination of these strains of mice is necessary in order to better facilitate a quantitative genetic analysis. Moreover, developmental and environmental studies would serve to clarify the genetic influences on muscle fiber composition.

The voltage-gated chloride channel, ClC-1, a member of the CLC family of proteins, is expressed predominantly in skeletal muscle cells. In this tissue, ClC-1 contributes to repolarisation and stabilisation of the membrane potential after an action potential. In the absence of ClC-1 function, voltage-gated sodium channels can recover from inactivation before the membrane potential has returned to resting levels, and hence can reopen without further stimulus, resulting in a run of contractions. Clinically, this phenomenon leads to the muscle stiffness disease myotonia. Members of the CLC family of proteins have been identified in many species from bacteria to mammals, and the X-ray crystallographic structure of a bacterial member of this family revealed a complex structure with 17 intramembrane helices. These proteins exist as a functional dimer, with a separate permeation pore within each subunit. There appears to be two separate gating mechanisms; the fast gate which acts on each pore independently and the slow or common gate operating on both pores simultaneously. The aim of this study was to identify functionally important regions within the ClC-1 channel, with the ultimate aim of elucidating the mechanisms involved in gating. / Thesis (PhDHealthSciences)--University of South Australia, 2006.

Thesis (PhD) -- University of South Australia, 1998

Thesis (Ph. D.)--University of Toronto, 2006. / Source: Dissertation Abstracts International, Volume: 67-06, Section: B, page: 3271. Includes bibliographical references.

Thesis (Ph. D.)--University of Washington, 1998. / Vita. Includes bibliographic references (leaves [126]-138).

Thesis (Ph. D.)--Ohio State University, 2004. / Document formatted into pages. Includes bibliographical references. Abstract available online via OhioLINK's ETD Center; full text release delayed at author's request until 2005 Aug. 2.

Thesis (Ph. D.)--University of Texas at Austin, 1998. / Vita. Includes bibliographical references (leaves 285-294). Available also in a digital version from Dissertation Abstracts.

Thesis (M.Sc.)--York University, 2006. Graduate Programme in Kinesiology and Health Science. / Typescript. Includes bibliographical references (leaves 69-74). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR29558

Thesis (M.S.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains viii, 119 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 97-101).