Thesis (Ph. D.)--University of Wisconsin--Madison, 1954. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1949. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 43-45).

Mode of access: Internet via World Wide Web. Available at http://hdl.handle.net/1947/9668. / "October 2008" Title from PDF cover (viewed on 25 September, 2009) Includes bibliographical references.

Thesis (Ph. D.)--Johns Hopkins University, 1920. / Biography.

Thesis (PH. D.)--Johns Hopkins University, 1920. / Biography.

From 1939 to 1942 Canada, allied to the United Kingdom, prepared to defend itself against chemical attack by Nazi Germany. The Canadian preparations represented one of Canadas many contributions to the cause of the British Commonwealth, and may have been used as one method to counter British requests for additional ground troops. After the Japanese attack at Pearl Harbor, Canada became part of an alliance with the United States and the United Kingdom. Canadian chemical warfare preparations went from defensive to offensive following the attack on Pearl Harbor and the entry of the United States into the war. The chemical warfare preparations included preparation and testing of toxic gases and smokes, smoke screening and flame weapons.<p> One of the most important Canadian contributions to the alliance was the establishment of the Suffield Field Experimental Station in Alberta. This base was particularly useful in carrying out chemical weapon trials, during which approximately 2000 Canadian citizens and soldiers were exposed to toxic gases. At the beginning of the war chemical warfare volunteers were completely covered in protective clothing except for a patch to allow for controlled chemical burns. But by 1942 Suffield staff was given permission to rewrite the regulations for the trials, and volunteers often received significant chemical injuries, including to the eyes. It would appear that the full body of knowledge available to the wartime scientists, especially information relevant to the long-term health outcomes of exposure to vesicant agents, was not applied in the conduct of the human experimentation.

From 1939 to 1942 Canada, allied to the United Kingdom, prepared to defend itself against chemical attack by Nazi Germany. The Canadian preparations represented one of Canadas many contributions to the cause of the British Commonwealth, and may have been used as one method to counter British requests for additional ground troops. After the Japanese attack at Pearl Harbor, Canada became part of an alliance with the United States and the United Kingdom. Canadian chemical warfare preparations went from defensive to offensive following the attack on Pearl Harbor and the entry of the United States into the war. The chemical warfare preparations included preparation and testing of toxic gases and smokes, smoke screening and flame weapons.<p> One of the most important Canadian contributions to the alliance was the establishment of the Suffield Field Experimental Station in Alberta. This base was particularly useful in carrying out chemical weapon trials, during which approximately 2000 Canadian citizens and soldiers were exposed to toxic gases. At the beginning of the war chemical warfare volunteers were completely covered in protective clothing except for a patch to allow for controlled chemical burns. But by 1942 Suffield staff was given permission to rewrite the regulations for the trials, and volunteers often received significant chemical injuries, including to the eyes. It would appear that the full body of knowledge available to the wartime scientists, especially information relevant to the long-term health outcomes of exposure to vesicant agents, was not applied in the conduct of the human experimentation.

No description available.

Comme l’a montré l’utilisation de sarin en Syrie en 2013, les agents chimiques de guerre restent une menace. L’exposition de populations est une situation d’urgence qui nécessite des moyens rapides et efficaces. La décontamination et le soin des personnes exposées restent une priorité. Les cheveux représentent une matrice couramment utilisée dans le domaine médico-légal. Dans ce travail, notre intérêt se porte sur la capacité du cheveu à capter et libérer des composés dans l’air, notamment l’ypérite, ainsi que sur l’efficacité de décontamination de cette matrice. Pour ce travail, nous avons utilisé deux composés aux propriétés physiques/chimiques proches de celles de l’ypérite : le salicylate de méthyle et le 2-chloroéthyl éthyl sulfure. Les deux similis ont été retenus par le cheveu avec une plus grande affinité pour le salicylate de méthyle. Nous avons observé une corrélation entre l’intensité d’exposition (influence de la dose et du temps) et la teneur en contaminants retrouvés sur les cheveux. Ces résultats montrent qu’il est possible d’utiliser le cheveu pour détecter une exposition individuelle. Après exposition, la teneur dans des cheveux laissés à désorber a été mesurée avec le salicylate de méthyle. Les résultats obtenus ont montré que les cheveux contaminés sont susceptibles de libérer les toxiques. Cela peut poser un problème sanitaire, qui implique donc que la décontamination des cheveux soit étudiée. Les protocoles de décontamination testés montrent une efficacité partielle (élimination de 40 à 80%). Ces résultats impliquent la nécessité d’optimiser les procédures actuelles ou de définir de nouveaux outils pour la décontamination du cheveu après exposition. / As shown by sarin use in Syria (2013), chemical warfare agents remain a threat. Chemical exposure of populations is an emergency situation, where quick and efficient means are mandatory. Decontamination and care of the victims are a priority. Scalp hair is routinely used as a biological matrix in forensic sciences. In this thesis work, interest focuses on hair capacity to trap and release compounds from atmosphere, especially sulphur mustard, as well as decontamination of this matrix. For this work, two molecules with similar physical/chemical properties to sulphur mustard were used: methyl salicylate and 2-chloroethyl ethyl sulphide. Both simulants were trapped by scalp hair, with higher affinity towards methyl salicylate. We observed a correlation between exposure intensity (influence from dose and time) and simulant content recovered from hair analysis. Results suggest that hair can be used to assess individual contamination. After exposure, evolution of methyl salicylate hair content has been measured. Results pointed out that contaminated hair can thereafter release the simulants. This can lead to health issue, highlighting the fact that hair decontamination must be investigated. Tested decontamination protocols showed a partial efficacy (40-80% removal). Those results evidenced the need to optimise current procedures or define new tools for hair decontamination after chemical exposure.

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Veronika Šulová Supervisor: doc. PharmDr. Lukáš Červený, Ph.D. External supervisor: pplk. doc. MUDr. Jaroslav Pejchal, Ph.D. et Ph.D. Title of diploma thesis: Changes of internal organs after percutaneous exposure to sulfur mustard Sulfur mustard is a chemical warfare agent belonging to the group of blistering agents. The theoretical section of the thesis is mainly focused on the description of acute toxic effects, the mechanism of action, and deals with the current possibilities of poisoning therapy. The experimental section is focused on monitoring the effect of sulfur mustard poisoning in the liver, lung, and kidney of female C57BL/6J mice after the percutaneous administration. This work aimed to evaluate markers of oxidative stress and histopathological changes of the selected organs at 3, 5, and 7 days after the poisoning. Ferric reducing antioxidant power (FRAP) and thiobarbituric acid reactive substances (TBARS) methods were used to determine markers of oxidative stress. Histopathological changes were evaluated microscopically using the hematoxylin-eosin staining method. The airness of the lung parenchyma was also assessed by computer image analysis. First, the LD50 of sulfur mustard was...