Global ETD Search

121	Design, development, and deployment of a locus specific mutation database : the PAHdb example Nowacki, Piotr Marek. January 1998 (has links) Genetics is concerned with inheritance, genomics with the study of genomes. Bioinformatics provides the tools to study the interface between the two. If a particular locus in the human genome could have 100 discrete alleles, then the genome (comprising an estimated 80,000 genes), could harbor 8 million different alleles. To record information about each of these alleles in a meaningful and systematic fashion is a task for the Mutation Database domain of bioinformatics. The HUGO Mutation Database Initiative is an international effort to capture, record and distribute information about variation in genomes. This initiative comprises a growing number of Locus-Specific Mutation databases, and a few large Federated Genomic databases [Cotton et al., 1998]. / Here I present work on a well recognized prototypical Locus-Specific database: PAHdb. PAHdb is a relatively large curated relational database. / This graduate project has had two major aims: to improve PAHdb , by careful analysis of version 1.0 and revision of its design, resulting in PAHdb version 2.0; to document the redesign process and share the experience by the conception of guidelines for content and structure of mutation databases in general. (Abstract shortened by UMI.) Mutation (Biology) -- Databases. Genetics -- Databases. Phenylketonuria. Metabolism, Inborn errors of.
122	How mitochondrial DNA mutations affect the growth of MCF-7 clones : a thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Cellular and Molecular Biology in the School of Biological Sciences, University of Canterbury, New Zealand / Sin, Angie Yuan Yan. January 2006 (has links) Thesis (M. Sc.)--University of Canterbury, 2006. / Typescript (photocopy). Includes bibliographical references (leaves 91-100). Also available via the World Wide Web.
123	The influence of APOBEC3G and deoxythymidylate kinase genetic diversity on HIV-1 hypermutation and response to treatment / Pace, Craig Stuart. January 2006 (has links) Thesis (Ph.D.)--Murdoch University, 2006. / Thesis submitted to the Division of Health Sciences. Bibliography: leaves 138-177.
124	Genetic code mutants of bacillus subtilis / Mat, Wai Kin. January 2007 (has links) Thesis (Ph.D.)--Hong Kong University of Science and Technology, 2007. / Includes bibliographical references (leaves 115-120). Also available in electronic version.
125	Mutagenic analysis of the decarboxylases and hydratases in parallel meta-fission pathways Miller, Scott Garrett. January 1900 (has links) Thesis (Ph. D.)--University of Texas at Austin, 2008. / Vita. Includes bibliographical references.
126	Incompatibility activity and expression of ribonucleotide reductase in Neurospora crassa / Haidari, Leila, January 1900 (has links) Thesis (M.Sc.) - Carleton University, 2002. / Includes bibliographical references (p. 88-93). Also available in electronic format on the Internet.
127	A genetic approach towards identifying genes involved in the targeting of plasmodesmal-associated protein kinase 1 Leonard, April. January 2008 (has links) Thesis (M.S.)--University of Delaware, 2008. / Principal faculty advisor: Jung-Youn Lee, Dept. of Plant & Soil Science. Includes bibliographical references.
128	Genomic instability and accelerated cellular senescence in laminopathy-based premature Liu, Baohua, January 2007 (has links) Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.
129	Using nucleic acids to repair [beta] -globin gene mutations Kierlin-Duncan, Monique Natasha, January 2007 (has links) Thesis (Ph. D.)--Duke University, 2007.
130	A study of DNA mutations in LDL receptor gene of Chinese patients with familial hypercholesterolaemia / Wong, Kwok-kit, Sunny. January 1997 (has links) Thesis (M. Phil.)--University of Hong Kong, 1998. / Includes bibliographical references (leaf 93-104).

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