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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
11

The histopathological analysis of cellular elements, accessory molecules and cytokines in mycobacterial granulomas from HIV positive and negative individuals

Wadee, Reubina 31 March 2014 (has links)
The immune response to infection with Mycobacterium tuberculosis (Mtb) involves complex interactions between macrophages, T-cells, cytokines and accessory molecules. Mycobacteria evade the host’s immune response by interfering with cell mediated immune systems. Granulomas are central to the host’s defenses against Mtb. These responses may be modified by immune alterations especially in patients co-infected with Human Immunodeficiency Virus (HIV). This study investigated the immunohistochemical profile of CD4+, CD8+, CD68+, Th-17 (also known as Interleukin-17 cells) and Forkhead box (FOXP3) cells, accessory molecule expression (HLA Class I and II) and selected cytokines (Interleukin 2, 4, 6 and Interferon-) of various cell types within mycobacterial granulomas, in lymph nodes from ten HIV negative and ten HIV positive patients. Tissue from a foreign body granuloma in skin was utilised for comparison. This study illustrated retention of CD4+ lymphocyte numbers within granulomas from HIV negative (-) patients but documented a reversal in the ratio of CD4+ to CD8+cells in granulomas from HIV positive (+) patients. Similar IL-17 cell counts were noted in mycobacterial granulomas from both HIV (-) and HIV (+) patients. CD68 was identified in all macrophages and HLA Class II stained 100% of cells. Mycobacterial granulomas from HIV (-) patients showed marginally lower numbers of HLA Class I cells when compared to those from HIV (+) patients. The percentage of FOXP3 positive cells differed significantly between mycobacterial granulomas from HIV (-) and HIV (+) patients. This study highlights the complex interplay between different cell types and cytokines secreted into the microenvironment that ultimately results in containment of the organism or disease progression. Tuberculosis mono-infection causes variation in the expression of cell markers such as FOXP3 with accompanying noteworthy changes in cytokine production in areas of granuloma formation. The alterations noted in TB and HIV co-infection are even greater and point toward evolution of micro-organism synergism with host demise.
12

Photoreactivation and ultraviolet inactivation of mycobacteria in air

Gillis, Hilton Leslie 08 1900 (has links)
No description available.
13

Subtyping of bacterial pathogens by polymerase chain reaction (PCR)-based techniques : studies on Mycobacterium spp. and Escherichia coli from humans and animals in Sweden and Thailand /

Ramasoota, Pongrama. January 1900 (has links) (PDF)
Diss. (sammanfattning) Uppsala : Sveriges lantbruksuniv. / Härtill 6 uppsatser.
14

Action of clofazimine on Mycobacterium avium and Mycobacterium intracellulare /

Warek, Ujwala, January 1990 (has links)
Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1990. / Vita. Abstract. Includes bibliographical references (leaves 53-60). Also available via the Internet.
15

Recovery of MAIS organisms from coastal swamps and key physiochemical variables influencing their growth /

Kirschner, Richard A. January 1991 (has links)
Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1991. / Vita. Abstract. Includes bibliographical references (leaves 86-91). Also available via the Internet.
16

Toll-like Receptor 2-Mediated Recognition of Mycobacterial Lipoproteins and Glycolipids

Drage, Michael Gerald January 2009 (has links)
Thesis (Ph.D.)--Case Western Reserve University, 2009 / Title from PDF (viewed on 19 August 2009) Department of Pathology Includes abstract Includes bibliographical references Available online via the OhioLINK ETD Center
17

Mycobacterial adenylyl cyclases Rv1625c and Rv0386 othodox vs. unorthodox catalysis /

Castro Pastrana, Lucila Isabel, January 2004 (has links)
Tübingen, Univ., Diss., 2004.
18

Molecular characterization of virulent strains of Mycobacterium tuberculosis /

Leong, Wing-man, Hilda. January 2005 (has links)
Thesis (M. Med. Sc.)--University of Hong Kong, 2005.
19

Kristallstruktur eines mycobacteriellen Porins

Faller, Michael. January 2004 (has links) (PDF)
Freiburg (Breisgau), Universiẗat, Diss., 2004.
20

Entwicklung einer Strategie zur Inaktivierung von Genen in Mycobacterium avium und Charakterisierung der potentiellen Virulenz-Gene sigE und mig

Morsczeck, Christian Oliver. January 2000 (has links) (PDF)
Köln, Universiẗat, Diss., 2000.

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