No description available.

This study analyzed the regenerative ability of cardiac muscle in the rat. Normal cardiac muscle from the rat was minced into one mm 3 fragments and homotransplanted into a gastrocnemius cavity of a non-sibling rat. At 45 days post surgery the regenerated tissue was removed and histological characteristics and oxidative capacity of the tissue were regenerate revealed the presence of myofibers. These myofibers of the cardiac regenerate typically exhibited centrally located, large, oval nuclei and branching. Both of these histological characteristics are typical of normal cardiac muscle. The absence of definitive intercalated discs though precluded conclusive identification of the myofibers of the cardiac regenerate as cardiac myofibers. The oxidative data showed that the cardiac regenerate consumed oxygen at a rate of 2.69X103 ± 2.96X102 (SE)y1 02/g X hr-1 this was found to be 4.9 times lower than normal cardiac tissue. The reason for this diminution is attributed to the observatiBall State UniversityMuncie, IN 47306

Thesis (M.Phil.)--Hong Kong University of Science and Technology, 2008. / Includes bibliographical references (leaves 119-125). Also available in electronic version.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1951. / Typescript with manuscript equations. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaf 34).

Thesis (Ph.D.)--University of Melbourne, Dept. of Medicine, The Royal Melbourne Hospital, 2010. / Typescript. Includes bibliographical references (leaves 164-202)

Thesis (Ph. D.)--University of Wisconsin--Madison, 1958. / Typescript. Abstracted in Dissertation abstracts, v. 19 (1959) no. 7, p. 1784-1785. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1980. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 182-198).

Thesis (Ph. D.)--University of Texas at Austin, 2004. / Supervisors: John A. Pearce and Jonathan W. Valvano. Vita. Includes bibliographical references.

Global assessment of myocardial function is widely performed by estimating ejection fraction (EF), but many common cardiac diseases initially affect the myocardium on a regional, rather than global, basis. Computed tomography (CT), most commonly applied to assess the coronary arteries, is a prime candidate for such regional analysis. This doctoral thesis makes steps towards regional CT functional analysis with two clinical and two technical contributions. The first clinical contribution focuses on evaluating the feasibility and utility of functional analysis with currently available CT technology. Our study found that CT strain analysis could identify regional wall motion abnormalities in cardiomyopathy that are not otherwise detected using conventional metrics of myocardial function such as EF. In order for cine CT of the heart to become routine clinical practice, improvements need to be made to the image acquisition protocol. The second clinical contribution focus on making these improvements with results pointing to the possibility of one millisievert range cine CT images with high (>50 milliseconds) temporal resolutions. Moving to technical considerations, a key concern has been how to better characterise the myocardium in CT. To address this, the first technical contribution examines the use of feature-based attribute vectors, which were found to improve image registration towards deriving more reliable motion estimations. The second technical contribution focus on developing a pipeline tailored towards CT strain analysis. Noting that CT naturally provides information in 3D, a 3D hyperelastic biomechanical model fitting method was evaluated. Analysis of an infarction model demonstrated that regional myocardial strain can be estimated in the 3D space and areas of infarction can be detected. By considering both technical and clinical perspectives, these advances will contribute to the the field of regional cardiac functional analysis towards improving patient care.

No description available.