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The involvement of heterotrimeric G proteins in the formation of neuromuscular junction and myogenesis /Lok, Ka Chun. January 2004 (has links)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2004. / Includes bibliographical references (leaves 102-115). Also available in electronic version. Access restricted to campus users.
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Schwann cells at the neuromuscular junction : factors influencing their mitosis and their role in regeneration /Love, Flora Marie, January 1999 (has links)
Thesis (Ph. D.)--University of Texas at Austin, 1999. / Vita. Includes bibliographical references (leaves 110-117). Available also in a digital version from Dissertation Abstracts.
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A balancing act for axonal outgrowth and synaptic differentiation at the neuromuscular junction /Meng, Min. January 2010 (has links)
Includes bibliographical references (p. 100-114).
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Newly characterized dystrophin-associated proteins (DAPs) identified in skeletal muscle using monoclonal antibodiesButterworth, Joanne. January 2002 (has links)
No description available.
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Formation and Characterization of in vitro Bioengineered Neuromuscular Junction ModelsCharoensook, Surapon Nathanael January 2018 (has links)
In vitro models of the neuromuscular junction (NMJ) are emerging as a valuable tool to study synaptogenesis, synaptic maintenance, and pathogenesis of neurodegenerative diseases. Many models have previously been developed using a variety of cell sources for muscle and motoneurons, but the models can be further improved by integrating beneficial features to better mimic the native milieu of NMJ development. We created a functional in vitro model of NMJ by bioreactor cultivation of C2C12 myoblasts, transdifferentiated myocytes and stem cell-derived motoneurons with electrical stimulation. Proper coculture medium and electrical stimulation led to improved functional coupling between the emerging motoneurons and myocytes, as evidenced by mature cellular structures, increased expression of neuronal and muscular genes, clusterization of acetylcholine receptors (AChRs) in the vicinity of motoneurons, and the response of the coculture to glutamate stimulation. To validate the models and demonstrate utility for pharmacological testing, we analyzed the potency of the drugs that affect key pathways during NMJ signal transduction, including acetylcholine (ACh) synthesis, ACh vesicular storage, ACh synaptic release, AChR activation, and ACh inactivation in the synaptic cleft. The models properly responded to the drugs in a concentration-dependent manner. The proposed in vitro NMJ model could thus be used in pharmacological screening and controlled studies of neuromuscular diseases.
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Neuromuscular junction disorganization in children with cerebral palsy a method to assess the distribution of multiple protein components /Robinson, Karyn Gail. January 2006 (has links)
Thesis (M.S.)--University of Delaware, 2006. / Principal faculty advisors: Robert E. Akins, Jr. and Deni S. Galileo, Dept. of Biological Sciences. Includes bibliographical references.
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Muscle induces neuronal expression of acetylcholinesterase in neuron-muscle co-culture : transcription regulation mediated by cAMP-dependent signaling /Jiang, Xiaosong. January 2003 (has links)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003. / Includes bibliographical references (leaves 132-149). Also available in electronic version. Access restricted to campus users.
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Functional roles of P2Y2 nucleotide receptor in the formation and maintenance of vertebrate neuromuscular junctions /Tung, Kwok Kwan. January 2003 (has links)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003. / Includes bibliographical references (leaves 127-140). Also available in electronic version. Access restricted to campus users.
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The transcriptional regulation of collagen-tailed (ColQ) subunit of acetylcholinesterase (AChE) in muscles /Lee, Hing Cheong. January 2003 (has links)
Thesis (M. Phil.)--Hong Kong University of Science and Technology, 2003. / Includes bibliographical references (leaves 132-154). Also available in electronic version. Access restricted to campus users.
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Schwann cell processes guide axons reinnervating the neuromuscular junctionKang, Hyuno 28 August 2008 (has links)
Not available / text
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