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Synthèse de poly(N-isopropylacrylamide)s modifiés par des groupements cholestérols et leur étude en solutions aqueusesSégui, Florence January 2007 (has links)
Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal.
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Poly (N-isopropylacrylamide) based microgels and their assemblies for organic molecule removal from waterParasuraman, Deepika Unknown Date
No description available.
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Synthèse de poly(N-isopropylacrylamide)s modifiés par des groupements cholestérols et leur étude en solutions aqueusesSégui, Florence January 2007 (has links)
Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal
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Mise au point de complexes liposome/polymère sensibles au pH pour la vectorisation d'agents anticancéreuxRoux, Emmanuelle January 2003 (has links)
Thèse numérisée par la Direction des bibliothèques de l'Université de Montréal.
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Poly(NIPAAm-co-AAm)-gold nanoshell composites for optically-triggered cancer therapeutic deliveryStrong, Laura 24 July 2013 (has links)
Chemotherapy regimens, one of the most common cancer treatments, are often dictated by dose-limiting toxicities. Also, the largest hurdle for translating novel biological therapies such as siRNA into the clinic is lack of an efficient delivery mechanism to get the therapeutic into malignant cells. Both of these situations would benefit from a minimally-invasive controlled release system that only delivers a therapeutic to the site of malignant tissue. This thesis presents work towards the creation of such a delivery platform using two novel material components: a thermally responsive poly[N-isopropylacrylamide-co-acrylamide] (NIPAAm-co-AAm) hydrogel and gold-silica nanoshells. Thermally responsive hydrogels undergo a physical property transition at their lower critical solution temperature (LCST). When transitioning from below to above the LCST, the hydrogel material expels large amounts of water and absorbed molecules. This phase change can be optically triggered by embedded gold-silica nanoshells, which rapidly transfer near-infrared (NIR) light energy into heat energy due to the surface plasmon resonance phenomena. When this material is loaded with absorbed drug molecules, drug release can be externally triggered by exposure to an NIR laser. Initial characterization of this material was accomplished using bulk hydrogel-nanoshell composites. Poly(NIPAAm-co-AAm)-nanoshell composites were synthesized via free radical polymerization. The LCST of the poly(NIPAAm-co-AAm) hydrogels was determined to be from 39-45 deg C, or slightly above physiologic temperature. The material was swollen in a drug solution of either doxorubicin (a common chemotherapeutic) or a 21bp dsDNA olgio (a model molecule for siRNA). Composites were then exposed to an 808 nm laser, which was found to trigger release of the therapeutics from the composite material. Further work has been done in translating this composite material to nano-scale sized particles, such that it could be injected intravenously, passively accumulate in tumor tissue, and be externally triggered to release therapeutics by exposure to an NIR laser. Sub-micron composite particles were synthesized using dissolvable gelatin templates with 500 nm wells. Analysis by transmission electron microscopy (TEM) indicates that these particles consist of gold nanoshells surrounded by a hydrogel coating. Dynamic light scattering (DLS) measurements were used to show that these particles display the same thermal properties as seen in the bulk material: collapsing in response to increased temperatures or NIR light exposure. Ultimately, the work in this thesis advances the development of a minimally-invasive, optically-triggered drug delivery platform.
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Synthesis of temperature-responsive PNIPAM/PTMA and their application in the catalyzed oxidation of alcohols to aldehydes and ketonesHuang, Jian-hao 23 August 2012 (has links)
Temperature-responsive poly(N-isopropylacrylamide) (PNIPAM)/ poly(2,2,6,6-tetramethylpiperidin-1-oxyl-4-yl methacrylate) (PTMA) copolymer are
synthesiszed by radical polymerization and atom transfer radical polymerization. The catalytic oxidation of alcohols to aldehydes and ketones using the NIPAM/PTMA copolymer as a catalyst was investigated. The copolymer were characterized by nuclear magnetic resonance spectroscopy, infrared spectroscopy, and gel permeation chromatography. The results of temperature-dependent UV/Vis absorption show that the lower critical solution temperature (LCST) is around 32-42 ¢J as the molecular percentage of PTMA is 0-6%. When the molecular percentage of PTMA is high than 6%, the LCST is not observed. The yield of the catalytic oxidation using the PNIPAM/PTMA copolymer as a catalyst is high than 99% within 30 min. The temperature-responsive PNIPAM/PTMA copolymer can be precipitated and purified by increasing temperature of the reaction solution higher than the LCST.
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Development of a "Self-Cleaning" Encapsulation Technology for Implantable Glucose MonitoringGant, Rebecca M. 2009 December 1900 (has links)
The increasing prevalence of diabetes and the severity of long-term complications have
emphasized the need for continuous glucose monitoring. Optically-based methods are
advantageous as they have potential for noninvasive or minimally invasive detection.
Fluorescence-based affinity assays, in particular, can be fast, reagentless, and highly
specific. Poly(ethylene glycol) (PEG) microspheres have been used to encapsulate such
fluorescently labeled molecules in a hydrogel matrix for implantation into the body. The
matrix is designed to retain the sensing molecules while simultaneously allowing
sufficient analyte diffusion. Sensing assays which depend upon a spatial displacement of
molecules, however, experience limited motility and diminished sensor response in a
dense matrix. In order to overcome this, a process of hydrogel microporation has been
developed to create cavities within the PEG that contain the assay components in
solution, providing improved motility for large sensing elements, while limiting leaching
and increasing sensor lifetime. For an implanted sensor to be successful in vivo, it should exhibit long-term stability and
functionality. Even biocompatible materials that have no toxic effect on surrounding
tissues elicit a host response. Over time, a fibrous capsule forms around the implant,
slowing diffusion of the target analyte to the sensor and limiting optical signal
propagation. To prevent this biofouling, a thermoresponsive nanocomposite hydrogel
based on poly(N-isopropylacrylamide) was developed to create a self-cleaning sensor
membrane. These hydrogels exist in a swollen state at temperatures below the volume
phase transition temperature (VPTT) and become increasingly hydrophobic as the
temperature is raised. Upon thermal cycling around the VPTT, these hydrogels exhibit
significant cell release in vitro. However, the VPTT of the original formula was around
33-34 degrees C, resulting in a gel that is in a collapsed state, ultimately limiting glucose
diffusion at body temperature. The hydrogel was modified by introducing a hydrophilic
comonomer, N-vinylpyrrolidone (NVP), to raise the VPTT above body temperature. The
new formulation was optimized with regard to diffusion, mechanical strength, and cell
releasing capabilities under physiological conditions. Overall, this system is a promising
method to translate a glucose-sensitive assay from the cuvette to the clinic for minimally
invasive continuous glucose sensing.
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Investigation of the Emission Properties of Quantum Dot-thermoresponsive Polymer Nanocomposite Hydrogels with TemperatureJuriani, Ameet Rajkumar 2010 May 1900 (has links)
This thesis presents a novel method for the preparation of quantum dot-thermoresponsive polymer nanocomposite hydrogels. The quantum dots (QD’s) were synthesized in a microwave reactor using a high temperature organometallic synthesis procedure. The initial hydrophobic surface layer on the QD’s was coated with an amphiphilic polymer to enable phase transfer from non-polar solvent to water followed by physical immobilization of the QD’s in the thermoresponsive polymer hydrogel by photopolymerization. Their temperature dependent emission properties were investigated as a function of concentration of the incorporated QD’s. The resultant temperature dependent changes in the position of the peak emission wavelength of the QD-polymer nanocomposite hydrogels were found to be due to the change in the physical environment causing increased interaction between the embedded amphiphilic polymer coated QD’s and/or due to aggregation of QD’s. This change in peak emission position was found to be reversible in the temperature range from 29 to 37 °C.
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Covalent Layer-by-Layer Synthesis of Responsive Porous FiltersAllen, Ainsley Larue 2011 May 1900 (has links)
Poly(N-isopropylacrylamide) (PNIPAM), a temperature responsive polymer, undergoes a phase change at a lower critical solution temperature (LCST) in aqueous solutions. For PNIPAM this temperature is 32 °C in water. Below the LCST, the polymer is readily solvated by water. As the temperature of the solution increases, the polymer undergoes a phase transition so that above the LCST it is no longer water soluble. The LCST of PNIPAM may be changed by the addition of salt solutions from the Hofmeister series which will follow the Hofmeister effect for salting-in and salting-out the polymer.
Temperature responsive polymers may be grafted to a surface in a variety of methods to create responsive thin films that exhibit a change in wettability. The surface wettability is directly related to the polymers ability to be solvated in its coil conformation. When PNIPAM is grafted to a surface, the surface becomes alternatively hydrophobic and hydrophilic in response to both temperature and the anions in the Hofmeister series which take the surface either above or below the LCST of PNIPAM.
The synthesis of responsive nanocomposite grafts was successfully applied to glass slides and three-dimensional surfaces, porous glass frits which were capable of controlling the passive flow rate. The nanocomposite graft was assembled in a covalent layer-by-layer approach to create more chemically robust surfaces, and also to incorporate nanoparticles into the graft for increased surface roughness and therefore improve wettability response. Because of a much greater inherent roughness to a glass frit, characterization of the polymers and nanoparticles was performed before they were covalently bound to the surface. The final product, a functionalized frit with a PNIPAM/SiO2 nanocomposite graft, was analyzed by observing changes in the passive permeation rate of the frit between water and salt solutions. These changes in flow were indicative of the surface bound PNIPAM changing between its hydrophilic and hydrophobic conformation in response to water and concentrations of kosmotropic salts such as sodium sulfate and sodium citrate. In addition to the solute response, the frit was also determined to be responsive to temperature and concentration. Water exhibited a passive flow rate 1000 times faster than a kosmotropic salt but had a similar flow rate to that a chaotropic salt. By measuring the flow rate of 0.5 M Na2SO4 at ~7 °C in a cold room and at room temperature it was observed that sodium sulfate in the cold room passed through the frit at a rate 100 times faster than at room temperature. Because of the hysteresis of PNIPAM documented in literature, washing procedures were kept consistent between experiments to achieve more reproducible results.
It was concluded that the frits were temperature responsive and had relative standard deviations below 25 percent for flow rates on a single frit. However, standard deviations of flow rates between frits were higher. This was likely due to a combination of factors, such as the frits’ pore size range of 10 μm resulting in the possibility of varied degrees of functionalization of each frit.
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Polymer Adsorption on the Air/Solution Interface Probed by Dynamic Surface Light ScatteringChang, Ai-Li 19 June 2002 (has links)
Surface Laser Light Scattering (SLLS) is a heterodyne detection technique used to probe the surface properties of fluid interfaces. These interfaces are either liquid/liquid or vapor/liquid, and they may include insoluble monolayers or polymer films deposited on liquid surfaces as well as microemulsions in solution at low concentration. This technique provides one with a nonperturbative way to obtain surface tension and viscosity. A diffraction grating is employed to provide a stable local oscillatior, hence selecting an accurate ripplon wave vector . This thesis deals with the investigation of the interface between air and solution consisting of the methanol and water mixture and poly(N-isopropylacrylamide) or PNIPAM which is one of the fascinating polymeric materials. The polymer PNIPAM shows distinct responses to variations in the surrounding environment (such as thermal gradient, change in pH, etc.). The surface tension extracted from the SLLS data using the Kelvin equation is found to agree well with that obtained by using the Wilhelmy plate method. For the range of wave vectors cm-1, the power spectrum detected in frequency domain can be fit to a Lorentzian profile. Our experiments show that when the volume percentage of methanol increases, the interfacial property becomes insensitive to the presence of PNIPAM.
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