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Hollow microneedles for molecular transport across skinDavis, Shawn Paul, January 2003 (has links) (PDF)
Thesis (Ph. D.)--School of Chemical Engineering, Georgia Institute of Technology, 2004. Directed by Mark R. Prausnitz. / Vita. Includes bibliographical references (leaves 151-158).
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Ocular drug delivery using microneedlesJiang, Ninghao. January 2006 (has links)
Thesis (Ph.D)--Chemical Engineering, Georgia Institute of Technology, 2007. / Committee Chair: Prausnitz, Mark R.; Committee Member: Allen, Mark; Committee Member: Edelhauser, Henry; Committee Member: Geroski, Dayle; Committee Member: Nickerson, John; Committee Member: Sambanis, Athanassios.
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Polymeric microneedles for transdermal drug deliveryPark, Jung-Hwan 05 1900 (has links)
No description available.
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Characterization of plastic hypodermic needlesBusillo, Eric 08 August 2008 (has links)
Significant potential for plastic hypodermic needles exists as an alternative to current steel needles, especially in developing regions where proper needle disposal is problematic. Needle reuse causes tens of millions of hepatitis and HIV infections each year. Plastic needles may reduce reusability and increase the opportunities for safe disposal. Plastic needles also will help with medical waste disposal, by removing metal from the waste stream, hence making it easier to reprocess needles and syringes into useful products such as car battery cases and pails.
This thesis presents the design and testing of one type of plastic hypodermic needle. The buckling and penetration characteristics of the needles were modeled and analyzed analytically and by finite element analyses. Experimental penetration tests using steel and plastic hypodermic needles and skin mimics, specifically polyurethane film and pig skin, were performed to determine penetration and friction forces. Penetration tests also were conducted to determine whether the needles could penetrate butyl rubber stoppers that cover drug vials. Various lubricants, including silicone oil and a medical grade silicone dispersion, were also used. In addition, the needles underwent perpendicular bending tests and cannula stiffness tests. Finally, fluid flow tests were conducted to determine fluid flow rates through the needles. Experimental results were compared to each other and finite element analyses and discussed.
The research presented in this thesis demonstrates that with further design modifications, plastic needles may become suitable for mass replacement of steel needles, thus helping to eradicate the many health and environmental risks brought upon by steel needles.
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A study to determine the economic feasibility in the use of disposable syringes with attached needles versus reusable syringes and needles in an air force hospital submitted ... in partial fulfillment of the requirements for the degree of Master of Hospital Administration ... /Aaron, Robert Vernon. January 1962 (has links)
Thesis (M.H.A.)--University of Michigan, 1962.
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A study to determine the economic feasibility in the use of disposable syringes with attached needles versus reusable syringes and needles in an air force hospital submitted ... in partial fulfillment of the requirements for the degree of Master of Hospital Administration ... /Aaron, Robert Vernon. January 1962 (has links)
Thesis (M.H.A.)--University of Michigan, 1962.
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A comparison of atmospheric PAHs in pine needles and high-volume sampler filters in the dayton metro areaTomashuk, Timothy A. 16 July 2010 (has links)
No description available.
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Landscape Evolution of the Needles Fault Zone, Utah, Investigated Through Chronostratigraphic and Terrain AnalysisGeiger, Faye L. 01 May 2014 (has links)
Arcing eastward from the deep gorge of Cataract Canyon on the Colorado River is a series of aligned valleys (graben) and ridges (horst). This unusual landscape has formed as subsurface salt deforms toward the river and dissolves away, causing the overlying rocks to fault, slide, and subside. Geologists have long been interested in this actively evolving area they call the Needles fault zone, because understanding its mechanics and origin may shed light on how faults work in general and similar, yet inaccessible places like offshore rift zones or even the surface of the Moon. Despite this interest, the timing and long-term patterns of deformation here and are poorly constrained.
This study uses analysis of digital landscape models to better delineate these patterns and provide better age constraints on the development of the Needles fault zone. We find that the Colorado River incision that led to deformation here began as recently as 1 million years ago, and that faulting due to subsurface salt movement initiated between 700 and 200 thousand years ago.
The first part of this study takes advantage of how the development of graben valleys has changed the path of many of the streams in the study area, resulting in numerous captured streams terminating into a type of sinkhole, called a swallow hole, that develops above opening faults. These fissures are so named because, by ongoingopening, they are “swallowing” material that is flushed into them by local drainages. By recording and numerically dating the exposed upper 6-14 m of basin-fill strata, we determined that sediment was deposited to an alluvial fan and to ponded water. We also compared calculated sediment yields over time to paleoclimate records for the region to test extant hypotheses about how drylands respond to changing climate of the same scale as modern climate change. Against expectations, our results suggest that the greatest sediment yield and storage in these upper basins occurred during the relatively warm and dry time from 9 to 5 thousand years ago, when overland flow to transport sediment was weak. This implies that we are actually measuring sediment storage, as the faults that form swallow holes were relatively less active, allowing sediment to accumulate, rather than be flushed out of the basins.
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Analysis of post-use hypodermic needle medical waste disposalHeffner, Heather Ann 07 June 2004 (has links)
No description available.
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Polymeric microneedles for transdermal drug deliveryPark, Jung-Hwan, January 2004 (has links) (PDF)
Thesis (Ph. D.)--School of Biomedical Engineering, Georgia Institute of Technology, 2004. Directed by Mark R. Prausnitz. / Includes bibliographical references (leaves 184-193).
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