Cervical cancer has a major impact on women’s lives especially in developing countries where it is the leading cause of death due to late presentation. Cervical cancer usually remains asymptomatic in the pre invasive and early stages until the disease is locally advanced. The treatment for cervical cancer is guided by the age and general health of the patient as well as the extent of the cancer and presence or nature of any complicating abnormalities. Radiotherapy is the major treatment modality for cervical cancer and approximately 60% of patients with cervical cancer receive radiotherapy at some point during the treatment of the disease. Cervical cancer and its treatment can result in physical, psychological and sex-related effects. Research problem, question and purpose: Little is known concerning cervical cancer treatment related effects South African women experience 12 months after completing treatment as no literature exploring this subject could be found. The research question is therefore: What long term effects do women treated for cervical cancer at an academic hospital in Johannesburg experience 12 months after completion of treatment? The purpose of the study is to explore the effects women experience after 12 months of treatment for cervical cancer with radiotherapy. Design: A qualitative method and descriptive phenomenological design was used for this study. The setting was the Department of Radiation Oncology at an academic hospital in Johannesburg. The population comprised all women diagnosed with cervical cancer who completed radiotherapy treatment 12 months prior the study. Purposive sampling was used and the sample totalled 16 (n=16). Data were collected using open-ended, unstructured interviews. Findings: The responses elicited from the interviews, women experience problems related to Physical, Social-economic. Psycho-spiritual and sexual problems of being treated for cervical cancer. Conclusion: Women experience physical problems which has an impact on their social-economical, psycho-spiritual and sexual lives as a result of long-term effects of cervical cancer and its treatment

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).

Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 67-74).

Thesis (Ph. D.)--University of Wisconsin, 1952. / Typescript (carbon copy). Charts laid in. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (doctoral)--Ludwig Maximilians-Universität zu München, 1979.

Thesis (Ph. D.)--University of Washington, 2007. / Vita. Includes bibliographical references (leaves 132-182).

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 4 uppsatser.

Thesis (Ph. D.)--University of Texas Health Science Center at Houston, School of Public Health, 2008. / Source: Dissertation Abstracts International, Volume: 69-07, Section: B, page: 4121. Advisers: Sara Strom; Maureen Sanderson. Includes bibliographical references.

Diss. (sammanfattning) Göteborg : Univ., 2009. / Härtill 4 uppsatser.

Submitted by INGRID DA SILVA SANTOS null (iingridsantos@hotmail.com) on 2017-06-26T03:09:39Z No. of bitstreams: 1 Dissertação de Mestrado_Repositório UNESP_INGRID DA SILVA SANTOS.pdf: 1875360 bytes, checksum: b760f2a2958eb68922d78501172c5f4e (MD5) / Approved for entry into archive by Luiz Galeffi (luizgaleffi@gmail.com) on 2017-06-28T16:45:33Z (GMT) No. of bitstreams: 1 santos_is_me_araca_par.pdf: 1437951 bytes, checksum: 9bb3ef4b8f15e4259996185982c7950e (MD5) / Made available in DSpace on 2017-06-28T16:45:33Z (GMT). No. of bitstreams: 1 santos_is_me_araca_par.pdf: 1437951 bytes, checksum: 9bb3ef4b8f15e4259996185982c7950e (MD5) Previous issue date: 2017-06-02 / Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM) / Evidências sugerem que o papilomavírus humano (HPV) está associado com um subgrupo de carcinomas de células escamosas da cabeça e pescoço (HNSCC). No entanto, a prevalência do HPV varia substancialmente dependendo do local anatômico e da região geográfica estudada. Aqui, nosso objetivo foi investigar a prevalência do HPV em amostras de tecido fresco de pacientes brasileiros com carcinoma de células escamosas (CEC) de boca e orofaringe combinando dois métodos confiáveis para a detecção do HPV. Foram recrutadas trinta e seis amostras de tecido fresco provenientes de CEC de boca (n= 27) e orofaringe (n= 9) para análises. As características sociodemográficas, estilo de vida e clinicopatológicas foram coletadas através dos prontuários. O DNA do HPV foi detectado por dois métodos: reação em cadeia da polimerase (PCR) em tempo real através de ensaio qualitativo de presença ou ausência do HPV-16, e testado para 37 genótipos usando Linear Array. A amplificação do gene β -globina funcionou como controle interno positivo para a análise do DNA em todas as amostras. O DNA do HPV não foi detectado em nenhum dos casos de amostras de tecido de pacientes com CEC em ambos os métodos utilizados. A ausência do HPV observada em nosso estudo pode sugerir que este não é um fator de risco prevalente nos CECs de boca e orofaringe nesta região geográfica. Os fatores de risco clássicos para o desenvolvimento desses tumores parecem ser ainda a principal causa nessa população brasileira. Investigações detalhadas do estilo de vida com maior amostragem precisam ser melhor exploradas para compreensão da baixa prevalência encontrada. / Evidence suggests that human papillomavirus (HPV) is associated with a subgroup of squamous cell carcinomas of the head and neck (HNSCC). However, the prevalence of HPV varies substantially depending on the anatomical site and geographic region studied. Here, our goal was to investigate the prevalence of HPV in fresh tissue samples from Brazilian patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx by combining two reliable methods for the detection of the HPV DNA. We recruited thirty-six fresh tissue samples from SCC of the oral cavity (n= 27) and oropharynx (n= 9) for analysis. The sociodemographic, lifestyle and clinicopathological characteristics were obtained from individual medical records. HPV DNA was detected by two methods: real-time polymerase chain reaction (PCR) through the qualitative assay of presence or absence for HPV-16, and tested for 37 genotypes by the Roche Linear Array. Amplification of the β-globin gene functioned as a positive internal control for DNA analysis in all samples. HPV DNA was detected in none of the tissue samples from patients with SCC in both methods. The absence of HPV observed in our study may suggest that this is not a prevalent risk factor in SCC of the oral cavity and oropharynx in this geographical region. The classic risk factors for the development of these tumors seem to be still the main cause in this Brazilian population. Detailed investigations of lifestyle with larger sample needs to be better explored to understand the low prevalence found. / FAPEAM: 120/2015