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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Showing 1 to 2 of 2 (0.037 seconds)

Spelling suggestions: "subject:"NMR off DNA"" "subject:"NMR oof DNA""

1

Vznik a stabilita DNA minivlásenek / The presence and stability of DNA mini-hairpins

Bušková, Hana January 2021 (has links)
The secondary structure of DNA is variable and depends on the sequence of nu- cleotides in a strand. While DNA can form duplexes, formations of three, four, or even a single strand have been observed in vivo and in vitro as well. In this thesis, we study the effect of small changes of oligonucleotide sequences on the stability of hairpins formed by DNA heptamers by 1 H nuclear magnetic resonance (NMR) spectroscopy. Suitable DNA sequences were selected based on symmetry rules and stability prediction by near- est neighbor model. Two-dimensional 1 H -1 H NOESY spectra were used to assign the 1 H resonances of aromatic hydrogens. Variable-temperature 1D spectra served for ob- taining melting curves, from which the thermodynamic properties of the hairpins were determined. The presence of hairpins in the solutions was confirmed by the character of the NOESY spectra, independence of melting temperature on oligonucleotide concen- tration, and comparison of competing melting-curve models of duplex and hairpin. Our results point out the importance of the order of the stem base pairs and contribute to the description of the extraordinary stability of DNA mini-hairpins. 1
2

Synthesis, Photochemical Properties and DNA Binding Studies of DNA Cleaving Agents Based on Chiral Dipyridine Dihydrodioxins Salts

Shamaev, Alexei E. 13 November 2015 (has links)
No description available.
Pharmacy Sciences
Biomedical Research
Molecular Physics
Molecular Chemistry
Chemistry
Pharmaceuticals
Organic Chemistry
Biochemistry
Molecules
synthesis of photoactive compounds
photoactivity
chiral separation
DNA binding
DNA cleavage
Drug-DNA interactions
femtosecond ultrafast spectroscopy
phoretic studies of DNA
mass-spectrometry of DNA
NMR of DNA

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