Thesis (M. Sc.)--University of Alberta, 2010. / Title from pdf file main screen (viewed on June 18, 2010). A thesis submitted to the Faculty of Graduate Studies and Research in partial fulfillment of the requirements for the degree of Master of Science in Engineering Management, Department of Mechanical Engineering, University of Alberta. Includes bibliographical references.

Thesis (M. S.)--Public Policy, Georgia Institute of Technology, 2006. / Shapira, Philip, Committee Chair ; Hicks, Diana, Committee Co-Chair ; Castillo, Marco, Committee Member.

Thesis (Ph. D.)--UCLA, 2007. / Vita. Includes bibliographical references.

Thesis (M.A.)--Michigan State University. Dept. of Sociology, 2008. / Title from PDF t.p. (Proquest, viewed on Aug. 7, 2009) Includes bibliographical references (p 29-31). Also issued in print.

Thesis (Ph.D)--Public Policy, Georgia Institute of Technology, 2008. / Committee Chair: Shapira, Philip; Committee Member: Hicks, Diana; Committee Member: Porter, Alan; Committee Member: Rogers, Juan; Committee Member: Schmoch, Ulrich.

The role of universities in supporting economic development has been explored in numerous studies emphasizing the mechanisms of technology transfer and knowl-edge spillover. However, in addition to these forms of intellectual capital, university scientists bring other resources into research collaboration and contribute to firm part-nerships in both direct and indirect ways. This thesis proposes the concept of resource spillover, which captures the various ways in which university scientists can benefit col-laborating firms. The study first analyzes firms, university scientists, and collaboration along with the concepts of ego, alter, and network ties in social capital theory; then it categorizes the resources possessed by university scientists into human capital, social capital, and positional capital, and tests the impact of each on the performance of a firm. The study finds that firms benefit from research collaboration in terms of both increased research capability and research output and improved public relations and research credibility. The study is carried out using a sample of new nanotechnology-based firms in the United States. As the U.S. government recognizes nanotechnology as providing scientific and technological opportunities with immense potential, this industry has be-come the recipient of significant federal R&D funding. In turn, because academic re-search has proven to be important to not only overall nanotechnology R&D but also in-dustrial R&D, it necessitates appropriate policy programs that support successful re-source spillover from academia and promote the development of industry.

Indiana University-Purdue University Indianapolis (IUPUI) / Carbon nanomaterials are widely produced and used in industry, medicine and scientific research. To examine the impact of exposure to nanoparticles on human health, the human airway epithelial cell line, Calu-3, was used to evaluate changes in the cellular proteome that could account for alterations in cellular function of airway epithelia after 24 h exposure to 10 μg/mL and 100 ng/mL of two common carbon nanoparticles, singleand multi-wall carbon nanotubes (SWCNT, MWCNT). After exposure to the nanoparticles, label-free quantitative mass spectrometry (LFQMS) was used to study differential protein expression. Ingenuity Pathway Analysis (IPA) was used to conduct a bioinformatics analysis of proteins identified by LFQMS. Interestingly, after exposure to a high concentration (10 μg/mL; 0.4 μg/cm2) of MWCNT or SWCNT, only 8 and 13 proteins, respectively, exhibited changes in abundance. In contrast, the abundance of hundreds of proteins was altered in response to a low concentration (100 ng/mL; 4 ng/cm2) of either CNT. Of the 281 and 282 proteins that were significantly altered in response to MWCNT or SWCNT, respectively, 231 proteins were the same. Bioinformatic analyses found that the proteins common to both kinds of nanotubes are associated with the cellular functions of cell death and survival, cell-to-cell signaling and interaction, cellular assembly and organization, cellular growth and proliferation, infectious disease, molecular transport and protein synthesis. The decrease in expression of the majority proteins suggests a general stress response to protect cells. The STRING database was used to analyze the various functional protein networks. Interestingly, some proteins like cadherin 1 (CDH1), signal transducer and activator of transcription 1 (STAT1), junction plakoglobin (JUP), and apoptosis-associated speck-like protein containing a CARD (PYCARD), appear in several functional categories and tend to be in the center of the networks. This central positioning suggests they may play important roles in multiple cellular functions and activities that are altered in response to carbon nanotube exposure. To examine the effect of nanotubes on the plasma membrane, we investigated the interaction of short purified MWCNT with model lipid membranes using a planar bilayer workstation. Bilayer lipid membranes were synthesized using neutral 1, 2-diphytanoylsn-glycero-3-phosphocholine (DPhPC) in 1 M KCl. The ion channel model protein, Gramicidin A (gA), was incorporated into the bilayers and used to measure the effect of MWCNT on ion transport. The opening and closing of ion channels, amplitude of current, and open probability and lifetime of ion channels were measured and analyzed by Clampfit. The presence of an intermediate concentration of MWCNT (2 μg/ml) could be related to a statistically significant decrease of the open probability and lifetime of gA channels. The proteomic studies revealed changes in response to CNT exposure. An analysis of the changes using multiple databases revealed alterations in pathways, which were consistent with the physiological changes that were observed in cultured cells exposed to very low concentrations of CNT. The physiological changes included the break down of the barrier function and the inhibition of the mucocillary clearance, both of which could increase the risk of CNT’s toxicity to human health. The biophysical studies indicate MWCNTs have an effect on single channel kinetics of Gramicidin A model cation channel. These changes are consistent with the inhibitory effect of nanoparticles on hormone stimulated transepithelial ion flux, but additional experiments will be necessary to substantiate this correlation.