The purpose of this study is to explore the national policies, strategies, and programmatic responses on HIV/AIDS in eight Southeast Asia Countries by analyzing the contents of the National Strategic Plans on HIV/AIDS (NSPs) and biennial country progress report to UNAIDS from these countries. METHODS: Thematic content analysis method was used to analyze a total of 24 documents of the National Strategic Plan on HIV/AIDS and Global AIDS Response Progress Report submitted to UNAIDS from Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Thailand and Viet Nam. NVivo10 qualitative analysis software was used for coding and organizing documents. RESULTS: 28 main categories with sub-categories emerged from coding and analysis of NSPs and country progress report documents from eight SEA countries. NSPs from all countries significantly failed to tackle key topics in policy, social and economic environment around HIV control such as women empowerment, illiteracy, armed conflicts, natural disaster and humanitarian emergencies. CONCLUSION: In order to align with the global HIV strategy to reach Millennium Development Goals to stop the spread of HIV by 2015, SEA countries should improve their NSPs and progress reports by addressing the political, social, cultural, and economic factors which urgently need to be addressed. New technologies and approaches are important for developing HIV interventions to stop the HIV epidemic, but addressing policy, economic and social environment around HIV epidemic and control in SEA regions is a key for those HIV intervention strategies and programs to be effective in controlling for HIV.