Bochum, Univ., Diss., 2002. / Computerdatei im Fernzugriff.

Bochum, Univ., Diss., 2002. / Computerdatei im Fernzugriff.

Bochum, University, Diss., 2002.

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 66-69).

No description available.

University, Diss., 2005--Saarbrücken.

<p> Electrical stimulation of areas in the diencephalon and central grey of the conscious rabbit produces a response of thumping the ground with the hindfeet. The response is not elicitable from the neocortex, striatum or internal capsule. Thumping movements occur mainly after offset of the eliciting stimulus and the likelihood of a response decreases regularly with time, suggesting the decay of a central excitatory state.</p> <p> Central stimulation which produces thumping behaviour tends to be aversive in tests for self-stimulation. Further, the behaviour can be elicited by peripheral electric shock. Therefore thumping behaviour may be a sign of fear in the rabbit.</p> / Thesis / Master of Arts (MA)

Signal transduction via the phosphoinositide (PI) second messenger system has key roles in the development and plasticity of the neocortex. The present study localized PI responses to individual cortical layers in slices of developing rat somatosensory cortex. The acetylcholine agonist carbachol and the glutamate agonist trans-1-amino-1,3-cyclopentanedicarboxylic acid (ACPD) were used to stimulate PI turnover. The PI responses were compared to the distribution of the corresponding PI-linked receptors in order to investigate the regional ontogeny of PI coupling to receptors in relation to neural development. The method for assessing PI turnover was modified from Hwang et al. (1990). This method images the PI response autoradiographically through the localizaton of [3H]cytidine that has been incorporated into the membrane-bound intermediate, cytidine diphosphate diacylglycerol. In each age group (postnatal days 4-30), carbachol resulted in more overall labeling than ACPD. For both agonists, the response peaked on postnatal day 10 (P10) and was lowest in the oldest age group. The laminar distribution of the carbachol PI response from P4-P16 corresponded fairly well with the laminar distribution of [3H]quinuclidinyl benzilate binding (Fuchs, 1995). However, in the subplate layer the carbachol response was strong while receptor binding was minimal. The carbachol response decreased after postnatal day 10, while the overall levels of receptor binding continued to increase. From P5 - P14, PI-linked metabotropic glutamate receptors are most concentrated in layer IV (Blue et al., 1997), whereas only on P6 was there a correspondingly high ACPD-initiated PI response in this layer. Unlike receptors, the PI response was strong in upper V (P4 - P12) and within layers II/III (P8 - P16). From P4 - P21, the subplate showed relatively high PI labeling compared to receptor binding. The several differences between the distribution of PI response and receptors suggest spatiotemporal heterogeneity of receptor coupling to second messenger systems.

No description available.

Universiẗat, Diss., 2004--Kiel. / Erscheinungsjahr an der Haupttitelstelle: 2003.