I will investigate applications of machine learning algorithms to medical data, adaptations of differences in data collection, and the use of ensemble techniques. Focusing on the binary classification problem of Parkinson’s Disease (PD) diagnosis, I will apply machine learning algorithms to a primary dataset consisting of voice recordings from healthy and PD subjects. Specifically, I will use Artificial Neural Networks, Support Vector Machines, and an Ensemble Learning algorithm to reproduce results from [MS12] and [GM09]. Next, I will adapt a secondary regression dataset of PD recordings and combine it with the primary binary classification dataset, testing various techniques to consolidate the data including treating the regression data as unlabeled data in a semi-supervised learning approach. I will determine the performance of the above algorithms on this consolidated dataset. Performance of algorithms will be evaluated using 10-fold cross validation and results will be analyzed in a confusion matrix. Accuracy, precision, recall, and F-score will be calculated. The expands on past related work, which has used either a regression dataset alone to predict a Unified Parkinson’s Disease Rating Scale score for PD patients, or a classification dataset to determine healthy or PD diagnosis. In past work, the datasets have not been combined, and the regression set has not been used to contribute to evaluation of healthy subjects.

Bibliography : leaves 168-189. / xix, 197 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Examines the role of renin-angiotensin and sympathetic nervous systems in hypertension development in the spontaneously hypertensive rat. / Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1995?

Hereditary Motor and Sensory Neuropathy-Russe (HMSNR) is a rare recessive form of Charcot-Marie-Tooth disease (CMT) that has been identified in the European Gypsy (Roma) population. Clinically, HMSNR manifests with typical CMT symptoms, while no associated features have been detected. Distinct neuropathological features of HMSNR include the presence of numerous clusters of thinly myelinated fibres originating from regenerative activity. HMSNR has been previously mapped to chromosome 10q using a large Bulgarian Gypsy kindred. Subsequent identification of related chromosome 10q haplotypes in Spanish and Romanian Gypsy families suggested a founder mutation in the Gypsy population as the cause of HMSNR. This thesis describes the refined mapping of the HMSNR gene by generating a high-density physical-genetic map of the HMSNR region containing 20 microsatellite markers and 229 SNPs and insertion/deletions which allowed meticulous mapping of recombination breakpoints resulting in a reduction of the HMSNR gene region from 1 Mb to just 63.8 kb. Analysis of positional candidates by direct sequencing included 14 known genes, 7 predicted genes and 42 expressed sequence tags (ESTs) nonoverlapping with the genes. 78 putative HMSNR mutations were identified, two of which exhibit complete segregation with the HMSNR phenotype. Both are located in the so-called testis-specific part of unexpected candidate gene hexokinase 1 (HK1), in a rare alternative untranslated 5’ exon of HK1 and in the adjacent downstream intron. Expression analysis of transcripts containing the alternative exon suggests that the exon is not confined to testis but may be expressed in the nervous system. It remains to be speculated how a gene that functions in the fundamental process of energy generation might be involved in a neuropathy. Further investigations are likely to expand the knowledge about the importance of HK1 in the peripheral nervous system and may elucidate new roles of HK1

Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed Feb. 7, 2008). Includes bibliographical references.

Diss. (sammanfattning) Uppsala : Sveriges lantbruksuniv. / Härtill 6 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 5 uppsatser.

Thesis (M. Sc.) Uppsala : Sveriges lantbruksuniv.

Thesis (Ph. D.)--Columbia University, 1919. / Vita. "Reprinted from vol. I, no. 3 ... and vol. I, no. 9 ... The Neurological bulletin ... c1918." Bibliography: p. 157-158.

Thesis (doctoral)--Lund University, 1992. / Added t.p. with thesis statement inserted.

Diss. (sammanfattning) Uppsala : Sveriges lantbruksuniv., 2009. / Härtill 4 uppsatser.