In the context of evolutionary robotics and neurorobotics, artificial neural networks, used as controllers for animats, are examined to identify principles of neuro-control, network organization, the interaction between body and control, and other likewise properties. Before such an examination can take place, suitable neuro-controllers have to be identified. A promising and widely used technique to search for such networks are evolutionary algorithms specifically adapted for neural networks. These allow the search for neuro-controllers with various network topologies directly on physically grounded (simulated) animats. This neuro-evolution approach works well for small neuro-controllers and has lead to interesting results. However, due to the exponentially increasing search space with respect to the number of involved neurons, this approach does not scale well with larger networks. This scaling problem makes it difficult to find non-trivial, larger networks, that show interesting properties. In the context of this thesis, networks of this class are called mid-scale networks, having between 50 and 500 neurons. Searching for networks of this class involves very large search spaces, including all possible synaptic connections between the neurons, the bias terms of the neurons and (optionally) parameters of the neuron model, such as the transfer function, activation function or parameters of learning rules. In this domain, most evolutionary algorithms are not able to find suitable, non-trivial neuro-controllers in feasible time. To cope with this problem and to shift the frontier for evolvable network topologies a bit further, a novel evolutionary method has been developed in this thesis: the Interactively Constrained Neuro-Evolution method (ICONE). A way to approach the problem of increasing search spaces is the introduction of measures that reduce and restrict the search space back to a feasible domain. With ICONE, this restriction is realized with a unified, extensible and highly adaptable concept: Instead of evolving networks freely, networks are evolved within specifically designed constraint masks, that define mandatory properties of the evolving networks. These constraint masks are defined primarily using so called functional constraints, that actively modify a neural network to enforce the adherence of all required limitations and assumptions. Consequently, independently of the mutations taking place during evolution, the constraint masks repair and readjust the networks so that constraint violations are not able to evolve. Such functional constraints can be very specific and can enforce various network properties, such as symmetries, structure reuse, connectivity patterns, connectivity density heuristics, synaptic pathways, local processing assemblies, and much more. Constraint masks therefore describe a narrow, user defined subset of the parameter space -- based on domain knowledge and user experience -- that focuses the search on a smaller search space leading to a higher success rate for the evolution. Due to the involved domain knowledge, such evolutions are strongly biased towards specific classes of networks, because only networks within the defined search space can evolve. This, surely, can also be actively used to lead the evolution towards specific solution approaches, allowing the experimenter not only to search for any upcoming solution, but also to confirm assumptions about possible solutions. This makes it easier to investigate specific neuro-control principles, because the experimenter can systematically search for networks implementing the desired principles, simply by using suitable constraints to enforce them. Constraint masks in ICONE are built up by functional constraints working on so called neuro-modules. These modules are used to structure the networks, to define the scope for constraints and to simplify the reuse of (evolved) neural structures. The concept of functional, constrained neuro-modules allows a simple and flexible way to construct constraint masks and to inherit constraints when neuro-modules are reused or shared. A final cornerstone of the ICONE method is the interactive control of the evolution process, that allows the adaptation of the evolution parameters and the constraint masks to guide evolution towards promising domains and to counteract undesired developments. Due to the constraint masks, this interactive guidance is more effective than the adaptation of the evolution parameters alone, so that the identification of promising search space regions becomes easier. This thesis describes the ICONE method in detail and shows several applications of the method and the involved features. The examples demonstrate that the method can be used effectively for problems in the domain of mid-scale networks. Hereby, as effects of the constraint masks and the herewith reduced complexity of the networks, the results are -- despite their size -- often easy to comprehend, well analyzable and easy to reuse. Another benefit of constraint masks is the ability to deliberately search for very specific network configurations, which allows the effective and systematic exploration of distinct variations for an evolution experiment, simply by changing the constraint masks over the course of multiple evolution runs. The ICONE method therefore is a promising novel evolution method to tackle the problem of evolving mid-scale networks, pushing the frontier of evolvable networks a bit further. This allows for novel evolution experiments in the domain of neurorobotics and evolutionary robotics and may possibly lead to new insights into neuro-dynamical principles of animat control.

S tím, jak se neustále vyvíjejí nové technologie pro energeticky náročná průmyslová odvětví, stávající zařízení postupně zaostávají v efektivitě a produktivitě. Tvrdá konkurence na trhu a legislativa v oblasti životního prostředí nutí tato tradiční zařízení k ukončení provozu a k odstavení. Zlepšování procesu a projekty modernizace jsou zásadní v udržování provozních výkonů těchto zařízení. Současné přístupy pro zlepšování procesů jsou hlavně: integrace procesů, optimalizace procesů a intenzifikace procesů. Obecně se v těchto oblastech využívá matematické optimalizace, zkušeností řešitele a provozní heuristiky. Tyto přístupy slouží jako základ pro zlepšování procesů. Avšak, jejich výkon lze dále zlepšit pomocí moderní výpočtové inteligence. Účelem této práce je tudíž aplikace pokročilých technik umělé inteligence a strojového učení za účelem zlepšování procesů v energeticky náročných průmyslových procesech. V této práci je využit přístup, který řeší tento problém simulací průmyslových systémů a přispívá následujícím: (i)Aplikace techniky strojového učení, která zahrnuje jednorázové učení a neuro-evoluci pro modelování a optimalizaci jednotlivých jednotek na základě dat. (ii) Aplikace redukce dimenze (např. Analýza hlavních komponent, autoendkodér) pro vícekriteriální optimalizaci procesu s více jednotkami. (iii) Návrh nového nástroje pro analýzu problematických částí systému za účelem jejich odstranění (bottleneck tree analysis – BOTA). Bylo také navrženo rozšíření nástroje, které umožňuje řešit vícerozměrné problémy pomocí přístupu založeného na datech. (iv) Prokázání účinnosti simulací Monte-Carlo, neuronové sítě a rozhodovacích stromů pro rozhodování při integraci nové technologie procesu do stávajících procesů. (v) Porovnání techniky HTM (Hierarchical Temporal Memory) a duální optimalizace s několika prediktivními nástroji pro podporu managementu provozu v reálném čase. (vi) Implementace umělé neuronové sítě v rámci rozhraní pro konvenční procesní graf (P-graf). (vii) Zdůraznění budoucnosti umělé inteligence a procesního inženýrství v biosystémech prostřednictvím komerčně založeného paradigmatu multi-omics.