Submitted by Jos? Henrique Henrique (jose.neves@ufvjm.edu.br) on 2018-08-09T22:31:02Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) daniel_almeida_freitas.pdf: 2420619 bytes, checksum: eef5412551343ea7660ddfdaac19b6e2 (MD5) / Approved for entry into archive by Rodrigo Martins Cruz (rodrigo.cruz@ufvjm.edu.br) on 2018-10-05T19:33:26Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) daniel_almeida_freitas.pdf: 2420619 bytes, checksum: eef5412551343ea7660ddfdaac19b6e2 (MD5) / Made available in DSpace on 2018-10-05T19:33:26Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) daniel_almeida_freitas.pdf: 2420619 bytes, checksum: eef5412551343ea7660ddfdaac19b6e2 (MD5) Previous issue date: 2017 / Funda??o de Amparo ? Pesquisa do estado de Minas Gerais (FAPEMIG) / O treinamento f?sico de intensidade leve e moderada est?o associados a efeitos neurais ben?ficos, contudo o exerc?cio de alta intensidade cont?nuo a efeitos neurais mal?ficos, pouco ? conhecido sobre os efeitos do treinamento intervalado de alta intensidade em ingl?s high intensity interval training (HIIT) em par?metros neuroqu?micos e de mem?ria. O presente estudo avaliou em ratos da linhagem Wistar os efeitos de 6 semanas de HIIT sobre o estado redox, concentra??o de mediadores inflamat?rios fator de necrose tumoral alfa (TNF-?), interleucina 1-beta (IL-1?), interleucina 6 (IL-6) e interleucina 10 (IL-10) e do fator neurotr?fico derivado c?rebro, do ingl?s brain derived neurothrophic factor (BDNF) no hipocampo e c?rtex cerebral. Al?m disso, foi avaliado o desempenho nas tarefas de reconhecimento espacial de objeto (hipocampo-dependente) e tarefa de reconhecimento de novo objeto (c?rtex-dependente). O presente estudo aprovado pela Comiss?o de Experimenta??o Animal (CEUA-UFVJM) sob n?mero de protocolo (031/2015). Ap?s 6 semanas de HIIT, os animais apresentaram redu??o de 28,57% do conte?do de esp?cies reativas ao ?cido tiobarbit?rico (TBARS) e aumento de 75% da atividade da enzima super?xido dismutase (SOD) e de 50,83% da capacidade antioxidante total pelo m?todo de redu??o do ferro (FRAP - ?Ferric reducing ability of plasma).no hipocampo. Al?m disso, o HIIT reduziu a concentra??o de mediadores neuroimunes no hipocampo (TNF-?, IL-1?, IL-6 e IL-10) respectivamente em (24,8%;13,9%; 33,93% e 16,33%), aumentou a concentra??o de BDNF em 60,21% e n?o interferiu no desempenho dos animais nas tarefas de reconhecimento espacial de objeto e reconhecimento de novo objeto. Nenhum dos par?metros investigados foram alterados no c?rtex cerebral. O presente estudo mostrou efeito positivo de 6 semanas de HIIT espec?fico por regi?o cerebral, sendo que tais modifica??es resultaram em efeitos neurais ben?ficos no hipocampo de animais submetidos a um treinamento for?ado. / Disserta??o (Mestrado) ? Programa Multic?ntrico de P?s-gradua??o em Ci?ncias Fisiol?gicas, Universidade Federal dos Vales do Jequitinhonha e Mucuri, 2017. / Although High Intensity Interval Training (HIIT) is associated with neuroprotection, there is no information available on the balance of pro and anti-inflammatory cytokines, as well as redox status, expression of neurotrophins and their impacts on different neural substrates and cognitive function. The present study evaluated the effects of a 6 weeks HIIT protocol on redox homeostasis, concentration of tumor necrosis factor alpha (TNF-?), interleukin 1-beta (IL-1?), interleukin 6 (IL -6) and interleukin 10 (IL-10) and brain derived neurotrophic factor (BDNF) in the hippocampus and cerebral cortex of Wistar rats.In addition, we evaluated the performance in the object spatial recognition tasks (hippocampus-dependent) and the new object recognition task (cortex-dependent). After 6 weeks of the HIIT protocol, the animals showed a reduction in the content of thiobarbituric acid reactive species (TBARS) and an increase in the activity of the enzyme superoxide dismutase (SOD) and in the total antioxidant capacity evaluated by the iron reduction method (FRAP - Ferric reducing ability of plasma) in the hippocampus. In addition, HIIT reduced the concentration of neuroimmune mediators in the hippocampus (TNF-?, IL-1?, IL-6 and IL-10), increased BDNF concentration and did not interfere in the performance of animals in the object recognition task. None of the investigated parameters were altered in the cerebral cortex. The present study was the first to show positive effect of 6 weeks of HIIT on specific brain-region, and such modifications result in a neuroprotective effect in the hippocampus of animals submitted to the stress of forced training.