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Interaction of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase with group I intron RNAsMyers, Christopher Allan 28 August 2008 (has links)
Not available / text
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Regulation of the p38 MAPK Signaling Pathway by the Circadian ClockGoldsmith, Charles Sidney 16 December 2013 (has links)
Mitogen activated protein kinase (MAPK) pathways are conserved biochemical signal transduction pathways in eukaryotic organisms. These signaling pathways demonstrate great versatility in their ability to detect various environmental stimuli and direct an appropriate cellular response. The circadian clock is a timekeeping mechanism that temporally coordinates diverse biological functions in an organism with the environment. Thus, it is not surprising that MAPK pathways have been utilized by the circadian clock to regulate many essential functions. Due to the conserved nature of circadian clocks and MAPK signaling pathways in eukaryotes, it is possible to develop hypotheses in simple model organisms, such as the fungus Neurospora, that are relevant to more complex organisms.
The OS-2 MAPK pathway in the filamentous fungus Neurospora is rhythmically activated by the circadian clock. In order to generate this rhythmic signal, the circadian oscillator directly regulates the rhythmic transcription of the os-4 MAPKKK and histidine phosphotransferase hpt-1, which are upstream regulators of the OS-2 MAPK. Also, the circadian rhythm in MAPK activation produces a more robust stress response during the time of the day that stress is most likely to be encountered. Based on these data, a model for the clock regulation of MAPK activation is presented, and a biological significance is assigned to the rhythms in this pathway.
Informed by these findings in Neurospora, the related p38 MAPK pathway was studied in mammalian cell lines that represent functionally distinct tissues in regards to clock function. A rhythm in p38 MAPK activation was observed in cells derived from the suprachiasmatic nucleus and fibroblasts of a mouse, the master pacemaker and a peripheral tissue, respectively. In cells that lacked a functional circadian oscillator, the rhythm in p38 activation was absent, and overall levels of p38 protein were lower. These data demonstrate a circadian clock-dependent oscillation in p38 activity.
These studies provide a basis to understand how the circadian clock generates endogenous rhythms in MAPK signal transduction pathways. Also, the characterization of clock-regulated stress response pathways provides an understanding of the adaptive advantage of the circadian clock.
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On nonself recognition in Neurospora Crassa: macroscopic and genetic studies /Micali, Oana Cristina, January 1900 (has links)
Thesis (Ph. D.)--Carleton University, 2003. / Includes bibliographical references (p. 200-228). Also available in electronic format on the Internet.
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The quinic acid gene cluster in neurospora sequence comparison and gene expression /Arnett, Diana R. January 2005 (has links)
Thesis (Ph.D.)--Kent State University, 2005. / Title from PDF t.p. (viewed June 29, 2007). Advisor: Asch, David K. Keywords: quinic acid gene cluster, neurospora crassa, catabolite repression. Includes bibliographical references (p. 136-153).
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Mutagenicity and mutagenic specificity of aflatoxins in Neurospora crassaOng, Tong-man, Brockman, Herman E. January 1970 (has links)
Thesis (Ph. D.)--Illinois State University, 1970. / Title from title page screen, viewed Sept. 3, 2004. Dissertation Committee: H.E. Brockman (chair), D.D. Pittman, W. Daniel, D. Weber, E.R. Willis. Includes bibliographical references (leaves 89-96) and abstract. Also available in print.
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Interaction of the Neurospora crassa mitochondrial tyrosyl-tRNA synthetase with group I intron RNAsMyers, Christopher Allan. January 2002 (has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2002. / Vita. Includes bibliographical references. Available also from UMI Company.
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Effect of N2 on the mutagenic and killing activities of ICR-170 in Neurospora crassaWhong, Wen-Zong. Brockman, Herman E. January 1976 (has links)
Thesis (Ph. D.)--Illinois State University, 1976. / Title from title page screen, viewed Dec. 7, 2004. Dissertation Committee: H.E. Brockman (chair), M. Neville, A. Richardson, F. Schwalm, D. Weber. Includes bibliographical references (leaves 125-138) and abstract. Also available in print.
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Location of aryl sulfatase in Neurospora crassaScott, Walter A. January 1970 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1970. / Vita. Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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Isolation and characterisation of the intermembrane space components of the mitochondrial TIM22 protein import machinery of Neurospora crassaVasiljev, Andreja. Unknown Date (has links) (PDF)
University, Diss., 2004--München.
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Identifikation, molekulare und funktionelle Charakterisierung des cpc-3 Gens : ein Beitrag zur Aufklärung der Allgemeinen Kontrolle der Aminosäurebiosynthesen von Neurospora crassa /Sattlegger, Evelyn. January 1996 (has links)
Hannover, Universiẗat, Diss., 1996.
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