The newborn heart possesses a higher tolerance to ischemia in comparison to adult hearts. Post-ischemic interventions that increase energy production are beneficial for recovery. These data suggest that the newborn heart holds on a very tight energetic plasticity and may not be capable to effectively respond to increases in energetic demand. Congenital heart defects can lead to the development of cardiac hypertrophy and often require surgical intervention. Using an animal model of newborn hypertrophy and biventricular isolated working heart we confirm the metabolic profile of the newborn rabbit heart, in which fatty acid oxidation provides the vast majority of energy to the heart. Our findings show that when right ventricle load is added, the increasing energy requirements are met by increasing glucose oxidation rates. Our data generated by the isolated biventricular working heart model further supports the concept of the newborn heart in a state of deficient energy reserve.

Thesis (M.S.N.)--Marshall University, 2002. / Title from document title page. Document formatted into pages; contains v, 60 p. Includes bibliographical references (p. 48-51).

No description available.

published_or_final_version / abstract / toc / Paediatrics and Adolescent Medicine / Doctoral / Doctor of Philosophy

published_or_final_version / abstract / toc / Paediatrics and Adolescent Medicine / Master / Master of Philosophy

No description available.

No description available.

Human newborns' response to decreased sound pressure level (SPL) was investigated with a localized headturning habituation procedure. Following criterion orientation (three headturns toward the sound out of four consecutive trials) and habituation (three consecutive trials with no headturns or headturns away from the sound), study 1 and 2 assessed newborn female infants' (M age = 41 hrs.) responses to lower-volume sounds immediately following habituation and following a 55-sec delay, respectively. Generalization of habituation to decreased volume following delay with recovery immediately following habituation was observed. Immediate recovery to decreased SPL contradicts a selective receptor adaptation view because a lower-intensity stimulus does not engage a separate set of receptor cells. It is proposed that generalization of habituation following delay involves recognition of the sound as familiar despite variations in volume.

Thesis (M.S.)--Virginia Polytechnic Institute and State University, 1993. / Vita. Abstract. Includes bibliographical references (leaves 71-78). Also available via the Internet.

Professional paper (M Nursing)--Montana State University--Bozeman, 2008. / Typescript. Chairperson, Graduate Committee: Elizabeth S. Kinion. Includes bibliographical references (leaves 25-27).