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The characterisation of nicotine binding sites on leukocytesMorgan, Deri January 2002 (has links)
No description available.
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The role of ubiquitin-proteasome degradation in assembly and expression of the nicotinic acetylcholine receptor /Christianson, John C. January 2002 (has links)
Thesis (Ph. D.)--University of Chicago, Committee on Neurobiology, 2002. / Includes bibliographical references. Also available on the Internet.
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Pharmacological and immunological identification of native [alpha]7 nicotinic receptors: evidence for homomeric and heteromeric [alpha]7 receptors /El-Hajj, Raed Ahmad., January 2008 (has links)
Thesis (M.S.)--Ohio State University, 2008. / Title from first page of PDF file. Non-Latin script record Includes bibliographical references (p. 27-32).
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Acute & subchronic NMDA receptor blockade alters nicotine-evoked dopamine releaseRodvelt, Kelli Renee. January 2007 (has links)
Thesis (M.A.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on April 10, 2009) Includes bibliographical references.
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Modulation of sensory transmission by nicotinic acetylcholine receptor activation /Genzen, Jonathan Robert. January 2002 (has links)
Thesis (Ph. D.)--University of Chicago, Pritzker School of Medicine, Committee on Neurobiology, June 2002. / Includes bibliographical references. Also available on the Internet.
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The pharmacology and nicotine-induced upregulation of neuronal nicotinic [alpha] 4 [beta] 2 receptors /Vallejo, Yolanda F. January 2002 (has links)
Thesis (Ph. D.)--University of Chicago, Pritzker School of Medicine, Department of Neurobiology, Pharmacology, and Physiology, June 2002. / Includes bibliographical references. Also available on the Internet.
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Isolation, purification and effect of ligands on the nicotinic cholinergic receptorKapp, Eugene Anthony January 1989 (has links)
The nicotinic cholinergic receptor protein of the fish electric organ, Torpedo fuscomaculata, has been isolated, purified and shown to represent a true model for the nAChR from other species and higher vertebrates. It is an integral membrane protein composed of four different subunits, tightly associated with other functional, but non-specific proteins. Purification of the nicotinic cholinergic receptor by chromatofocusing demonstrates an improved method over that of affinity and ion-exchange chromatography. Gel chromatography and SDS-polyacrylamide gel electrophoresis show evidence of four subunits; a(40-44 kDa), 6(53 kDa ),'Y(63 kDa) and 6(66 kDa) despite some degradation of receptor molecules by intracellular proteases. Spectrophotometric and fluorimetric studies of receptor-ligand interactions, show the functional and chemical integrity of the receptor to remain intact after solubilisation. The effect of cholinergic ligands on purified receptor preparations indicate quenching of the intrinsic fluorescence of the receptor. Agonists, like acetylcholine, bind and cause local conformational transitions, changing the active region from a hydrophobic to a hydrophilic environment. This phenomenon is illustrated by the 10-fold increase in fluorescence when the receptor is in a desensitised state. Antagonists, such as d-Tubocurarine, block this conformational transition. In vitro rectus abdominis muscle preparations . show the nitrosamines, dimethylnitrosamine and diphenylnitrosamine, to be true agonists of the nAChR. However their low affinity and specificity for the receptor precludes them as photoaffmity labelling agents. Photoactivation of dimethylnitrosamine occurs when associated with an acidic hydrogen at the active site of the receptor, suggesting energy-transfer labelling to be more facile than photoaffmity labelling. The membrane-bound receptor, in the presence of these nitrosamines, undergoes conformational transitions regulating the opening and closing of the ion-channel. Desensitisation and receptor activation are shown to involve one and the same molecular transition.
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Expression of multiple populations of nicotinic acetylcholine receptors in bovine adrenal chromaffin cellsWenger, Bryan W., January 2003 (has links)
Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xii, 120 p.; also includes graphics. Includes bibliographical references (p. 110-120).
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Regions of the nicotinic acetylcholine receptor involved in assembly /Leston, Alison M. January 2000 (has links)
Thesis (Ph. D.)--University of Chicago. / Includes bibliographical references. Also available on the Internet.
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Development of a novel delay discounting task : evaluation of nicotinic receptor blockade /Roseman, Paige Lee. January 2010 (has links)
Thesis (Honors)--College of William and Mary, 2010. / Includes bibliographical references (leaves 50-53). Also available online.
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