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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

The design, synthesis, and application of new amino acid-based modular N-ethylenediamine ligands /

Richmond, Meaghan L. January 2005 (has links)
Thesis (Ph.D.)--Brown University, 2005. / Vita. Thesis advisor: Christopher T. Seto. Includes bibliographical references (leaves 50-53, 112-114, 156-158). Also available online.

Class pi glutathione S-transferase: unfolding and conformational stability in the absence and presence of G-site ligands

Erhardt, Julija January 1996 (has links)
A thesis submitted to the Faculty of Science, University of the Witwatersrand, in fulfilment of the requirements for the degree of Doctor of Philosophy, Johannesburg, 1996 / The glutathione S-transferases (GST) are a supergene family of h0111o-or heterodimeric Phase II detoxification enzymes which catalyse the S-conjugation between glutathione and an electrophilic substrate. The active site can be divided into two adjacent functional regions; a highly specific Gssite for binding the physiological substrate glutathione and a nonspecific If-site for binding nonpolar electrophilic substrates. Unfolding of porcine class Pi isoenzyme (pGSTPl~l) was monitored under equilibrium conditions using different physicochemical parameters. The coincidence of unfolding curves obtained with functional and structural probes, the absence of thermodynamically stable intermediates such as a folded monomer, and the dependence of pGSTPl··l stability upon protein concentration, indicate a cooperative and concerted two-state unfolding transition between native dimeric pGSTPl-l and unfolded monomeric enzyme. Equilibrium and kinetic unfolding experiments employing tryptophan fluorescence and enzyme activity measurements were preformed to study the effect of ligand binding to the G-site on the unfolding and stability of the porcine class pi glutathione S-transferase against urea. The presence of glutathione caused a shift in the equilibrium-unfolding curves towards lower urea concentrations and enhanced the first-order rate constant for unfolding suggesting a destabilisation of the pGSTPl-l structure against urea. The presence of either glutathione sulphonate or S-hexylglutathione, however, produced the opposite effect in that their binding to the G-site appeared to exert a stabilising effect against urea. The binding of these glutathione analogues also reduced significantly the degree of cooperativity of unfolding indicating a possible change in the protein's unfolding pathway. / MT2017

Molecular mechanisms of peroxisome proliferator-activated receptor signaling

Dowell, Paul T. 09 June 1998 (has links)
Peroxisome proliferator-activated receptors (PPARs) are members of a large group of ligand-regulated transcription factors that includes nuclear receptors for steroid and thyroid hormones, retinoids and vitamin D���. Synthetic fibrates and thiazolidinediones that bind to and activate PPARs are used efficaciously in humans to remedy hypertriglyceridemia and non-insulin dependent diabetes mellitus, respectively. The objective of the studies described herein was to elucidate the molecular mechanisms of ligand-dependent PPAR signaling. Several PPAR ligands, including WY-14,643, were demonstrated to directly induce PPAR�� conformational changes as evidenced by a differential protease sensitivity assay. Conformational changes were induced in a dose-dependent manner which paralleled that of ligand to induce transcriptional activation. Direct interaction of ligands with, and the resulting conformational alterations in, PPAR�� may facilitate interaction of the receptor with transcriptional intermediary factors and thus may underlie the molecular basis of ligand-dependent transcriptional activation mediated by PPAR��. The yeast two hybrid screen was utilized to identify downstream components of the PPAR�� signaling pathway. Using this technique, the coactivator proteins, p300 and steroid receptor coactivator-1 (SRC-1), were identified as PPAR��-interacting proteins and WY-14,643 potentiated these interactions. p300 also enhanced the transcriptional activation properties of PPAR�� and, therefore, can be considered a bona fide coactivator for this nuclear receptor. Nuclear receptor corepressor (NCoR) was also isolated as a PPAR��-interacting protein from a yeast two hybrid screen. In contrast to the ligand enhanced PPAR��-coactivator interactions, WY-14,643 inhibited NCoR interaction with PPAR��. NCoR and the coactivators, p300 and SRC-1, were also demonstrated to require distinct receptor regions for efficient interaction with PPAR��. Results described herein demonstrate that ligand induces PPAR�� conformational changes, promotes PPAR��-coactivator (p300 and SRC-1) interactions, and inhibits PPAR��-NCoR interactions. We hypothesize that such molecular events are critical for ligand-dependent transcriptional activation by PPAR��. These results contribute additional knowledge as to the molecular mechanisms of PPAR-dependent signaling and may act as a starting part for the improvement and/or development of therapeutic strategies aimed at manipulating this signaling pathway. / Graduation date: 1999

Neuron-ligand pathfinding studies by atomic force microscopy and other surface-sensitive methods

Zhang, Zhanping. January 2006 (has links)
Thesis (Ph. D.)--University of Delaware, 2006. / Principal faculty advisor: Thomas P. Beebe, Jr., Dept. of Chemistry & Biochemistry. Includes bibliographical references.

The anticancer properties of gold (III) complexes with tridentate cyclometalated, porphyrinato and glycosylated ligands

Yan, Jing, 严静 January 2011 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy

Structural characterization of B-DNA and its interactions with cations and intercalating ligands

Howerton, Shelley B. 05 1900 (has links)
No description available.

Identifying ligands of the C-terminal domain of cardiac expressed connexin 40 and assessing its involvement in cardiac conduction disease /

Keyser, Rowena J. January 2007 (has links)
Thesis (MScMed)--University of Stellenbosch, 2007. / Bibliography. Also available via the Internet.

Regulation of vein, an activating ligand of the drosophila EGF receptor

Wang, Shu-Huei, January 2003 (has links)
Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xv, 189 p.; also includes graphics (some col.) Includes bibliographical references (p. 168-189). Available online via OhioLINK's ETD Center

Aspects of ruthenium benzoquinone chemistry /

Kalinina, Dar?ia. January 2006 (has links)
Thesis (M.Sc.)--York University, 2006. Graduate Programme in Chemistry. / Typescript. Includes bibliographical references. Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR29571

Two new resorcinarenes : a pyridine & acetic acid ligand for metal coordination and a deep-cavity nitroquinoxaline resorcinarene /

Vernetti, Samantha Sizemore, January 2006 (has links) (PDF)
Thesis (M.S.)--Brigham Young University. Dept. of Chemistry and Biochemistry, 2006. / Includes bibliographical references.

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