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The effect of bovine casein peptides on cytokine and nitric oxide production by macrophagesXiao, Chaowu, 1962- January 1996 (has links)
Three bovine casein peptides, LLY, PGPIPN, and TTMPLW, have been reported to stimulate phagocytosis of sheep red blood cells by murine macrophages. TTMPLW also protected mice against Klebsiella pneumoniae infection. The purpose of this study was to investigate the effects of these three peptides on cytokine (TNF-$ alpha$ and IL-6) production and nitric oxide (NO) release by bone marrow macrophages (BMM). The peptides alone were incapable of stimulating cytokine production or NO release in naive or IFN-$ gamma$-primed BMM. However, when BMM were coincubated with the peptides (1.0 $ mu$M) and LPS (100 ng/ml), an augmentative effect on TNF-$ alpha,$ IL-6 and NO production was observed. The peptides increased the response of BMM to stimulation with LPS in a dose- and time-dependent manner. Of the three peptides, TTMPLW (0.01, or 1.0 $ mu$M) had the greatest augmentative effect on NO production by LPS-stimulated BMM. Tumor necrosis factor-$ alpha$ production peaked after 4 hr stimulation, and decreased rapidly thereafter. Among three peptides, TTMPLW induced the highest amount of TNF-$ alpha$ production at a concentration of 1.0 $ mu$M. When used at a concentration as low as 0.01 $ mu$M, TTMPLW and PGPIPN, but not LLY, potentiated TNF-$ alpha$ production. All the peptides (1.0 $ mu$M) stimulated IL-6 production by BMM, which plateaued after 12 hr. The auto/paracrine TNF-$ alpha$ produced by LPS-stimulated BMM was partially responsible for release of NO. After all the TNF-$ alpha$ was neutralized, release of NO was reduced by about 21% (P $<$ 0.01). However, neutralization of IL-1$ beta$ and IL-6 did not have any effect on NO production by LPS-stimulated BMM. These results demonstrate that bovine casein peptides can costimulate naive macrophages with LPS for proinflammatory cytokine production and NO release and may play a role in host defense against pathogens.
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The role of nitric oxide in carrageenan-induced hyperalgesia /Osborne, Michael G. January 1999 (has links)
This thesis studied the role of spinal nitric oxide (NO) in carrageenan-induced dermal hyperalgesia in the rat hindpaw by means of intrathecal (i.t.) administration of various NO synthase (NOS) inhibitors. A spinal role for NO in carrageenan-induced thermal hyperalgesia was confirmed by dose-dependently reducing the hyperalgesia with a non-selective NOS inhibitor. Next, it was determined that a relatively selective neuronal NOS (nNOS) inhibitor and two relatively selective inducible NOS (iNOS) inhibitors were able to reduce carrageenan-induced thermal hyperalgesia. Finally, early administration of either an nNOS or an iNOS inhibitor had no significant effect on carrageenan-induced thermal hyperalgesia. However, late administration of an iNOS, but not an nNOS inhibitor, significantly reduced the thermal hyperalgesia. We therefore suggest that iNOS contributes to only the late stages of carrageenan-induced thermal hyperalgesia, while nNOS likely plays a role throughout the entire time course of the injury.
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Lack of Effect of Aerobic Physical Exercise on Endothelium-Deived Nitric Oxide Concentrations in Healthy Young SubjectsYamamoto, Kanami, Kondo, Takaaki, Kimata, Akiko, Ueyama, Jun, Shirotori, Aya, Okada, Yoshiko, Sakui, Daisuke, Nakashima, Masahiro, Yamada, Sumio 10 1900 (has links)
No description available.
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Vasomotor and anti-oxidant effects of anti-ischaemic therapies.Liberts, Elizabeth A. January 2007 (has links)
Title page, table of contents and abstract only. The complete thesis in print form is available from the University of Adelaide Library. / Nitric oxide (NO) plays a fundamental role in vascular homeostasis including vasomotor tone, platelet adhesion and aggregation. The current studies examine various aspects of NO responses, including: the methodology for assessment of vascular NO responses, and identification of factors reponsible for poor responsiveness and pharmacological modulation of these responses. / http://proxy.library.adelaide.edu.au/login?url= http://library.adelaide.edu.au/cgi-bin/Pwebrecon.cgi?BBID=1277081 / Thesis (Ph.D.) -- University of Adelaide, School of Medicine, 2007
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Hypoxia and the heart : the role of nitric oxide in cardiac myocytes and endothelial cells /Strijdom, Hans. January 2007 (has links)
Dissertation (PhD)--University of Stellenbosch, 2007. / Bibliography. Also available via the Internet.
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Acetylcholine receptors and nitric oxide synthase in the central nervous system of the tobacco hornworm Manduca sexta /Vermehren Petersen, Anke. January 2003 (has links)
Thesis (Ph.D.)--Tufts University, 2003. / Adviser: Barry A. Trimmer. Submitted to the Dept. of Biology. Includes bibliographical references (leaves 165-178). Access restricted to members of the Tufts University community. Also available via the World Wide Web;
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The role of prostaglandins, nitric oxide and oxygen in the ductus arteriosi of the pre-term chicken embryo (Gallus domesticus)Greyner, Henry José. Dzialowski, Edward M. January 2007 (has links)
Thesis (M.S.)--University of North Texas, Dec., 2007. / Title from title page display. Includes bibliographical references.
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Experimental studies on endotoxin infusion in human : evaluation of pharmacological immunomodulation by adenosine and nicotinamide /Soop, Anne, January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.
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Experimental and computational study of vibrational energy transfer in nitric oxideWhite, Allen Ray, January 2007 (has links)
Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 192-196).
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The effects of some peptide hormones on osteoblast-like cells : with specific focus on oxytocin and vasopressin /Lagumdzija, Alena, January 2005 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.
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