Thesis (Ph.D.)-- University of Adelaide, Dept. of Physics, 1956. / Typewritten copy. Includes bibliographical references (leaves 141-144).

Thesis (Ph. D.)--Brigham Young University. Dept. of Physiology and Developmental Biology, 2006. / Includes bibliographical references (p. 109-113).

Thesis (Ph. D.)--University of Texas at Austin, 2008. / Vita. Includes bibliographical references.

京都大学 / 0048 / 新制・課程博士 / 博士(医学) / 甲第18507号 / 医博第3927号 / 新制||医||1005(附属図書館) / 31393 / 京都大学大学院医学研究科医学専攻 / (主査)教授 渡邉 大, 教授 近藤 玄, 教授 斎藤 通紀 / 学位規則第4条第1項該当 / Doctor of Medical Science / Kyoto University / DFAM

Adula (Botula) falcata Gould (Soot-Ryen, 1955) lives commonly as a byssally attached rock borer in soft mudstone reefs at Bolinas and Moss Beach, California (Figure 1). Keen (1963) reports that Adula falcata has been collected from the intertidal to a depth of ten fathoms. Its distribution is from Coos Bay, Oregon, to Cape San Lucas, Lower California (Hertlein and Strong, 1946), and collection data indicate a range as far south as Peru (Soot-Ryen, 1955). While is possesses the protective advantage of living cryptically, Adula falcata is subjected to an environmental stress not faced by epifaunal mytillids; namely, it must function within a burrow into which sediment material is being continuously deposited from both particle laden water passing over its burrow entrance and the mudstone byproducts of its own mechanical boring. The following is a comparative study on the ciliary mechanisms of feeding, digestion, and sediment removal in Adula falcata. Sediment removal could hardly be considered separately from feeding and digestion, as it is during these latter two processes that sediment is resolved from potential food material and extruded from the burrow. Aside from publications of a purely taxonomic nature, the sole direct references to Adula falcata have been in Lloyd’s (1897) observations on lamellibranch rock boring and Yonge’s (1955) comprehensive work on the adaptation and evolution of the boring habit in the Family Mytilidae. It was, in fact, Yonge’s observations on the role of Figure 1. A lateral view of the burrow of Adula falcata. The mudstone burrow has been cracked open to expose the left side of the enclosed bivalve. This byssally attached mussel had withdrawn from the head of the excavation and had extended its siphonal process for feeding. Other noteworthy features include the furry incrustation on the posterodorsal triangle of the valve and a partially eroded umbone.

Die retinale in vivo Bildgebung gewann in den letzten 2 Jahrzehnten zunehmend an Bedeutung. Es fehlt aber häufig die Korrelation der in vivo erstellten quasi „histologischen“ Aufnahmen mit der tatsächlichen Histologie. An der Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Würzburg wurde ein standardisiertes System zur vergleichenden in vivo/ex vivo und histologischen retinalen Bildgebung des menschlichen Auges etabliert. In der vorliegenden „proof of concept study“ konnte der Arbeitsablauf erfolgreich gezeigt werden. Es wurden Abläufe geschaffen, die die ex vivo multimodale retinale Bildgebung analog zur in vivo Bildgebung an denselben Geräten ermöglichen. Die histologische Aufarbeitung des Gewebes erfolgt im Anschluss und ermöglicht die Korrelation von technisch gefundenen Veränderungen mit lichtmikroskopisch beschriebenen Auffälligkeiten. Diese histologischen Korrelate tragen zum besseren Verständnis von in vivo gefundenen Veränderungen bei. Gleichzeitig verbessern neu gefundene Auffälligkeiten in der in vivo Bildgebung das Verständnis und Früherkennung vieler retinaler Erkrankungen. Die Vorteile exzellent konservierter, aufbereiteter und histologisch untersuchter Proben wurde hier am Beispiel der CNTF-Expression dargestellt. Es konnte gezeigt werden, dass dieses Zytokin insbesondere bei neovaskulärer AMD in den Fotorezeptoraußensegmenten exprimiert wird. / Retinal in vivo imaging has become increasingly important over the past two decades. However, there is often no correlation between the almost histological image quality made in vivo and the actual histology. A standardized system for comparing in vivo/ex vivo and histological retinal imaging of the human eye was established at the “Klinik und Poliklinik für Augenheilkunde des Universitätsklinikums Würzburg”. In this "proof of concept study" the workflow could be successfully demonstrated. Procedures were created that enable ex vivo multimodal retinal imaging analogous to in vivo imaging on the same devices. The histological processing of the tissue is then carried out and enables the correlation of technically found changes with abnormalities described by light microscopy. These histological correlations contribute to a better understanding of changes found in vivo. At the same time, newly found abnormalities in in vivo imaging improve the understanding and early detection of many retinal diseases. The advantages of excellently preserved, processed and histologically examined samples were presented here using CNTF expression as an example. It could be shown that this cytokine is expressed in the photoreceptor outer segments, particularly in neovascular AMD.

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