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京都大学 / 新制・課程博士 / 博士(理学) / 甲第24388号 / 理博第4887号 / 新制||理||1699(附属図書館) / 京都大学大学院理学研究科数学・数理解析専攻 / (主査)教授 牧野 和久, 教授 並河 良典, 教授 長谷川 真人 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DGAM

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Topological order is a new field of research involving exotic physics. Among other things it has been suggested as a means for realising fault-tolerant quantum computation. Topological degeneracy, i.e. the ground state degeneracy of a topologically ordered state, is one of the quantities that have been used to characterize such states. Topological order has also been suggested as a possible quantum information storage. We study two-dimensional lattice models defined on a closed manifold, specifically on a torus, and find that these systems exhibit topological degeneracy proportional to the genus of the manifold on which they are defined. We also find that the addition of lattice dislocations increases the ground state degeneracy, a behaviour that can be interpreted as artificially increasing the genus of the manifold. We derive the fusion and braiding rules of the model, which are then used to calculate the braiding properties of the dislocations themselves. These turn out to resemble non-abelian anyons, a property that is important for the possibility to achieve universal quantum computation. One can also emulate lattice dislocations synthetically, by adding an external field. This makes them more realistic for potential experimental realisations. / Topologisk ordning är ett nytt område inom fysik som bland annat verkar lovande som verktyg för förverkligandet av kvantdatorer. En av storheterna som karakteriserar topologiska tillstånd är det totala antalet degenererade grundtillstånd, den topologiska degenerationen. Topologisk ordning har också föreslagits som ett möjligt sätt att lagra kvantdata. Vi undersöker tvådimensionella gittermodeller definierade på en sluten mångfald, specifikt en torus, och finner att dessa system påvisar topologisk degeneration som är proportionerlig mot mångfaldens topologiska genus. När dislokationer introduceras i gittret finner vi att grundtillståndets degeneration ökar, något som kan ses som en artificiell ökning av mångfaldens genus. Vi härleder sammanslagningsregler och flätningsregler för modellen och använder sedan dessa för att räkna ut flätegenskaperna hos själva dislokationerna. Dessa visar sig likna icke-abelska anyoner, en egenskap som är viktiga för möjligheten att kunna utföra universella kvantberäkningar. Det går också att emulera dislokationer i gittret genom att lägga på ett yttre fält. Detta gör dem mer realistiska för eventuella experimentella realisationer.

In this study, an improved bit-array representation method for structural topology optimization using the Genetic Algorithm (GA) is proposed. The issue of representation degeneracy is fully addressed and the importance of structural connectivity in a design is further emphasized. To evaluate the constrained objective function, Deb's constraint handling approach is further developed to ensure that feasible individuals are always better than infeasible ones in the population to improve the efficiency of the GA. A hierarchical violation penalty method is proposed to drive the GA search towards the topologies with higher structural performance, less unusable material and fewer separate objects in the design domain in a hierarchical manner. Numerical results of structural topology optimization problems of minimum weight and minimum compliance designs show the success of this novel bit-array representation method and suggest that the GA performance can be significantly improved by handling the design connectivity properly. / Singapore-MIT Alliance (SMA)

The emergence of many-body physical phenomena from the quantum mechanical properties of atoms can be studied using ultracold alkali gases. The ability to manipulate both Bose-Einstein condensates (BECs) and degenerate Fermi gases (DFGs) with designer potential energy landscapes, variable interaction strengths and out-of-equilibrium initial conditions provides the opportunity to investigate collective behaviour under diverse conditions. With an appropriately chosen wavelength, optical standing waves provide a lattice potential for one target species while ignoring another spectator species. A “tune-in” scheme provides an especially strong potential for the target and works best for Li-Na, Li-K, and K-Na mixtures, while a “tune-out” scheme zeros the potential for the spectator, and is pre- ferred for Li-Cs, K-Rb, Rb-Cs, K-Cs, and 39K-40K mixtures. Species-selective lattices provide unique environments for studying many-body behaviour by allowing for a phonon-like background, providing for effective mass tuning, and presenting opportunities for increasing the phase-space density of one species. Ferromagnetism is manifest in a two-component DFG when the energetically preferred many-body configuration segregates components. Within the local density approximation (LDA), the characteristic energies and the three-body loss rate of the system all give an observable signature of the crossover to this ferromagnetic state in a trapped DFG when interactions are increased beyond kF a(0) = 1.84. Numerical simulations of an extension to the LDA that account for magnetization gradients show that a hedgehog spin texture emerges as the lowest energy configuration in the ferromagnetic regime. Explorations of strong interactions in 40K constitute the first steps towards the realization of ferromagnetism in a trapped 40K gas. The many-body dynamics of a 87Rb BEC in a double well potential are driven by spatial phase gradients and depend on the character of the junction. The amplitude and frequency characteristics of the transport across a tunable barrier show a crossover between two paradigms of superfluidity: Josephson plasma oscillations emerge for high barriers, where transport is via tunnelling, while hydrodynamic behaviour dominates for lower barriers. The phase dependence of the many-body dynamics is also evident in the observation of macroscopic quantum self trapping. Gross-Pitaevskii calculations facilitate the interpretation of system dynamics, but do not describe the observed damping.

The emergence of many-body physical phenomena from the quantum mechanical properties of atoms can be studied using ultracold alkali gases. The ability to manipulate both Bose-Einstein condensates (BECs) and degenerate Fermi gases (DFGs) with designer potential energy landscapes, variable interaction strengths and out-of-equilibrium initial conditions provides the opportunity to investigate collective behaviour under diverse conditions. With an appropriately chosen wavelength, optical standing waves provide a lattice potential for one target species while ignoring another spectator species. A “tune-in” scheme provides an especially strong potential for the target and works best for Li-Na, Li-K, and K-Na mixtures, while a “tune-out” scheme zeros the potential for the spectator, and is pre- ferred for Li-Cs, K-Rb, Rb-Cs, K-Cs, and 39K-40K mixtures. Species-selective lattices provide unique environments for studying many-body behaviour by allowing for a phonon-like background, providing for effective mass tuning, and presenting opportunities for increasing the phase-space density of one species. Ferromagnetism is manifest in a two-component DFG when the energetically preferred many-body configuration segregates components. Within the local density approximation (LDA), the characteristic energies and the three-body loss rate of the system all give an observable signature of the crossover to this ferromagnetic state in a trapped DFG when interactions are increased beyond kF a(0) = 1.84. Numerical simulations of an extension to the LDA that account for magnetization gradients show that a hedgehog spin texture emerges as the lowest energy configuration in the ferromagnetic regime. Explorations of strong interactions in 40K constitute the first steps towards the realization of ferromagnetism in a trapped 40K gas. The many-body dynamics of a 87Rb BEC in a double well potential are driven by spatial phase gradients and depend on the character of the junction. The amplitude and frequency characteristics of the transport across a tunable barrier show a crossover between two paradigms of superfluidity: Josephson plasma oscillations emerge for high barriers, where transport is via tunnelling, while hydrodynamic behaviour dominates for lower barriers. The phase dependence of the many-body dynamics is also evident in the observation of macroscopic quantum self trapping. Gross-Pitaevskii calculations facilitate the interpretation of system dynamics, but do not describe the observed damping.

Most amino acid sequences are predicted to specify a single three-dimensional protein structure. However, the identification of "metamorphic" proteins, which can adopt two folds from a single amino acid sequence, has challenged the one sequence/one structure paradigm. Polar-to-hydrophobic substitutions have been suggested computationally as one mechanism to decrease structural specificity, allowing the population of novel folds. Here, we experimentally investigate the role of polar-to-hydrophobic substitutions on structural specificity in the homodimeric ribbon-helix-helix protein Arc repressor. Previous work showed that a single polar-to-hydrophobic surface substitution in the strand region of Arc repressor (Arc-N11L) populates the wild-type fold and a novel dimeric "switch" fold. In this work, we investigate an Arc repressor variant with the N11L substitution plus two additional polar-to-hydrophobic surface substitutions (Arc-S-VLV). We determine that this sequence folds into at least three structures: both dimer forms present in Arc-N11L, and a novel octamer structure containing higher stability and less helicity than the dimer folds. We are able to isolate and stabilize a core of the S-VLV octamer by limited trypsinolysis and deletion mutagenesis (Arc-VLV 4-44). The shortened construct contains only the octameric structure by removing disordered C-terminal segments nonessential for this fold. A two-dimensional NMR spectrum of VLV 4-44 and subsequent trypsinolysis of this construct suggests that at least two types of subunits comprise the S-VLV octamer: subunits structured from residues 4 to 44 and subunits structured from residues 4 to 31. Crystal trials of trypsinolyzed Arc-VLV 4-44 yielded several leads, suggesting that obtaining a high resolution structure of the S-VLV octamer is possible. Relatedly, we determine that the proline residues flanking the Arc repressor strand act in concert as "gatekeepers" to prevent aggregation in the S-VLV sequence. We also find that three highly hydrophobic surface substitutions in the Arc repressor strand region are necessary and sufficient to promote higher-order oligomer formation. In summation, this work reveals in an experimental context that progressive increases in polar-to-hydrophobic surface substitutions populate increasingly diverse, structurally degenerate folds. These results suggest that "metamorphic" as well as "polymetamorphic" proteins, which adopt numerous folds, are possible outcomes for a single protein sequence.

This thesis is devoted to the study of holomorphic Poisson structures and Lie algebroids, and their relationship with differential equations, singularity theory and noncommutative algebra. After reviewing and developing the basic theory of Lie algebroids in the framework of complex analytic and algebraic geometry, we focus on Lie algebroids over complex curves and their application to the study of meromorphic connections. We give concrete constructions of the corresponding Lie groupoids, using blowups and the uniformization theorem. These groupoids are complex surfaces that serve as the natural domains of definition for the fundamental solutions of ordinary differential equations with singularities. We explore the relationship between the convergent Taylor expansions of these fundamental solutions and the divergent asymptotic series that arise when one attempts to solve an ordinary differential equation at an irregular singular point. We then turn our attention to Poisson geometry. After discussing the basic structure of Poisson brackets and Poisson modules on analytic spaces, we study the geometry of the degeneracy loci---where the dimension of the symplectic leaves drops. We explain that Poisson structures have natural residues along their degeneracy loci, analogous to the Poincar\'e residue of a meromorphic volume form. We discuss the local structure of degeneracy loci that have small codimensions, and place strong constraints on the singularities of the degeneracy hypersurfaces of log symplectic manifolds. We use these results to give new evidence for a conjecture of Bondal. Finally, we discuss the problem of quantization in noncommutative projective geometry. Using Cerveau and Lins Neto's classification of degree-two foliations of projective space, we give normal forms for unimodular quadratic Poisson structures in four dimensions, and describe the quantizations of these Poisson structures to noncommutative graded algebras. As a result, we obtain a (conjecturally complete) list of families of quantum deformations of projective three-space. Among these algebras is an ``exceptional'' one, associated with a twisted cubic curve. This algebra has a number of remarkable properties: for example, it supports a family of bimodules that serve as quantum analogues of the classical Schwarzenberger bundles.