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The neuroscience & ethics of cognitive enhancement in healthy individualsMohamed, Ahmed Dahir January 2013 (has links)
No description available.
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Synthetic studies n bioactive natural products. Part I, An approach towards the nootrophic agent huperzine A. Part II, Synthesis of the tricarbonyl subunit of rapamycinJeffrey, Scott C. 04 April 1996 (has links)
Graduation date: 1996
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Natural product synthesis via cyclobutanes : part I, Asymmetric synthesis of (+)-byssochlamic acid, part II, An approach to the nootropic agent huperzine AKim, Jungchul 02 November 2000 (has links)
PART I. Asymmetric syntheses of both natural (+)- and nonnatural (-)-
byssochlamic acid via a [2+2] photoaddition-cycloreversion strategy are
described. X-ray crystallographic analysis of the cyclohexylamine salt 99 showed
that the structure of the monomethyl ester 100 from esterase hydrolysis of 44
was originally misassigned as 56. The enantiomeric relationship of the two
diolides 106 and 70 permitted syntheses of nonnatural byssochlamic acid (-)-3
and natural byssochiamic acid (+)-3 from enantiopure alcohol (+)-64 and from its
enantiomer (-)-110, respectively. Through the use of (��)-103 to reach both
enantiomers of byssochlamic acid (3) and subsequent epimerization of the npropyl
chain, it was proved that the cis configuration of the two alkyl substituents
is strongly preferred in the natural product.
PART II. An asymmetric approach towards the nootropic agent huperzine A
is described. Formation of cyclobutane 122 with the desired stereochemistry was
accomplished using intramolecular [2+2] photoaddition of the enantiopure enone
121. Attempts to prepare the methoxypyridine system via an azadiene Diels-
Alder reaction were unsuccessful. However, intramolecular Michael addition of
181 produced silyl ether 182 which was converted into the pyridone 187 by
treatment with hydrogen fluoride followed by selenoxide elimination. Attempts to
effect the key sigmatropic rearrangement of ketone 197 into a direct precursor of
huperzine A were unsuccessful. / Graduation date: 2001
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Design and synthesis of nanoparticle "PAINT-BRUSH" like multi-hydroxyl capped poly(ethylene glycol) conjugates for cancer nanotherapyKrishnan, Vinu. January 2008 (has links)
Thesis (M.S.)--University of Akron, Dept. of Biomedical Engineering, 2008. / "August, 2008." Title from electronic thesis title page (viewed 12/9/2009) Advisor, Stephanie T. Lopina; Committee members, Amy Milsted, Daniel B. Sheffer, Daniel Ely; Department Chair, Daniel B. Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
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Pharmaceutical dreams the search for cognition-enhancing medications for schizophrenia /Bromley, Elizabeth Ann, January 1900 (has links)
Thesis (Ph. D.)--UCLA, 2008. / Vita. Includes bibliographical references (leaves 276-312).
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A Critical Discourse Analysis of Cognitive Enhancement Advertising: The Contemporary Mind as a CommodityHamilton, Mindy January 2018 (has links)
No description available.
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Behavioural and physiological effects of two aniracetam analoguesFisher, Kim Noël January 1994 (has links)
The behavioural and electrophysiological consequences of two newly developed aniracetam analogues were investigated in male Long-Evans rats. Results indicate that an intraperitoneal (i.p.) injection of LD38.2 significantly improved retention in a two odour olfactory discrimination task. However, three different dosages of LN1 did not facilitate memory in the task. In rats with chronically implanted electrodes, both compounds rapidly crossed the blood brain barrier (BBB) after an i.p. injection and influenced several parameters of the field excitatory postsynaptic potential (EPSP) in the CA1 and dentate gyrus regions of the hippocampus. The enhancement of the field EPSP following LD38.2 administration may be related to the drug's ability to facilitate memory in the olfactory discrimination task. Compounds, like LD38.2, that enhance both hippocampal transmission and performance in learning/memory tasks in laboratory rodents may have implications for the treatment of clinical memory disorders.
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Behavioural and physiological effects of two aniracetam analoguesFisher, Kim Noël January 1994 (has links)
No description available.
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