Global ETD Search

41	Exploring the many facets of cell death Ménard, Isabelle. January 2007 (has links) This thesis summarises research performed with the intent of exploring the many facets of cell death. In the first part of the thesis, the fate of the formin-homology domain containing protein FHOD1 during apoptosis is examined (research performed in the laboratory of Dr. Sophie Roy) and evidence for the cleavage of FHOD1 by caspase-3 at the SVPD616 site is demonstrated. Moreover, the C-terminal FHOD1 cleavage product is shown to translocate to the nucleolus where it inactivates RNA polymerase I transcription. / In the second part of the thesis, the role of the RNA-binding protein HuR in cancer cell migration and invasion, as well as in multidrug resistance is determined using RNA interference to knockdown the expression of HuR in HeLa and KB-V1 cells respectively (research performed in the laboratory of Dr. Imed Gallouzi). In this part of the thesis, HuR is shown to promote cancer cell migration and invasion by stabilizing the beta-actin mRNA in a U-rich-dependent manner. Moreover, evidence is shown for the potential involvement of HuR in the phenomenon of multidrug resistance possibly through the post-transcriptional regulation of the multidrug resistance 1 gene. Cell Death. Apoptosis. Nuclear Proteins. RNA-Binding Proteins. Drug Resistance, Neoplasm. Drug Resistance, Multiple.
42	Cell cycle control by components of cell anchorage / Gad, Annica, January 2005 (has links) Diss. (sammanfattning) Stockholm : Karolinska institutet, 2005. / Härtill 4 uppsatser.
43	Molecular genetic markers of prostate cancer development / Valdman, Alexander, January 2003 (has links) Licentiatavhandling (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 3 uppsatser.
44	Hypoxia inducible factor 1a : molecular mechanisms of regulation / Wilson, William J., January 2002 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 4 uppsatser.
45	p57Kip2, a glucocorticoid-induced CDK inhibitor, involved in cell proliferation, apoptosis and differentiation / Samuelsson, Magnus, January 2003 (has links) Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.
46	Vitamin D3-mediated transcriptional repression : of the granulocyte-macrophage colony stimulating factor gene / Towers, Terri L. January 1998 (has links) Thesis (Ph. D.)--Cornell University, May, 1998. / Vita. Includes bibliographical references (leaves 154-181).
47	Transcription elongation mediated by the chromatin functions of Nap1 Del Rosario, Brian Cruz. January 2008 (has links) Thesis (Ph. D.)--University of Virginia, 2008. / Title from title page. Includes bibliographical references. Also available online through Digital Dissertations.
48	The role of histone chaperones in chromatin structure and gene expression / Adkins, Melissa Wess. January 2006 (has links) Thesis (Ph.D. in Biochemistry & Molecular Genetics) -- University of Colorado at Denver and Health Sciences Center, 2006. / Typescript. Includes bibliographical references (leaves 147-164). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
49	Muscle-specific regulations of serum response factor by differential DNA binding affinity and cofactor interactions Chang, Priscilla Shin-Ming. January 2001 (has links) (PDF) Thesis (Ph. D.) -- University of Texas Southwestern Medical Center at Dallas, 2001. / Vita. Bibliography: 91-102.
50	Regulation of the histone chaperone molecules Nap1p and nucleoplasmin by phosphorylation Calvert, Meredith Emily Kennedy. January 2007 (has links) Thesis (Ph. D.)--University of Virginia, 2007. / Title from title page. Includes bibliographical references. Also available online through Digital Dissertations.

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