The problem addressed in this study was the assessment of the knowledge of newly graduated registered Purse candidates about Total Parenteral Nutrition and the effects of practice on knowledge. The study used a quasi-experimental approach to determine the amount of knowledge the subjects possess about Total Parenteral Nutrition at the time of employment and after a period of six months working with patients receiving this therapy.An investiagtor made multiple choice test consisting of thiry items was used to assess the knowledge of the subjects. A score of 75% on the test instrument was considered to indicate adequate knowledge of Total Parenteral Nutrition therapy.The sample was a convenience sample consisting of 33 newly graduated registered nurse candidates. Associate, diploma and baccalaureate graduates were represented in the study.All subjects in the study scored less than 67% on either test during the study. The results of this study may have been influenced by the small number of exposures to patients receiving Total Parenteral Nutrition therapy.Ball State UniversityMuncie, IN 47306