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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Oligonucleotide-based lunimescent detection platform utilizing iridium (III) complexes

Leung, Ka Ho 27 May 2015 (has links)
Luminescent transition metal complexes have arisen as viable alternatives to organic dyes for sensory applications due to their notable advantages. This thesis aimed to synthesize different kinds of Ir(III) complexes, explore their interactions with DNAs and investigate their application for the construction of label-free oligonucleotide-based sensing platforms. A series of Ir(III) complexes incorporating a variety of C^N and N^N donor ligands were synthesized and were shown to exhibit G-quadruplex-selective binding properties via emission titration, UV/vis titration, fluorescence resonance energy transfer melting and G-quadruplex fluorescent intercalator displacement experiments. These G-quadruplex-selective Ir(III) complexes were utilized as signal transducers to monitor the conformational changes of oligonucleotides in label-free oligonucleotide-based luminescent detection platforms for metal ion (Sr2+), small molecules (GSH and ATP), protein (human neutrophil elastase) and enzyme activities (polymerase, hepatitis C virus NS3 helicase).
42

Synthesis, characterizations and applications of C2'-modified oligonucleotide analogues

Peng, Chang Geng. January 2007 (has links)
No description available.
43

Synthesis physicochemical and biological studies on oligonucleotides containing D-arabinose

Noronha, Anne Marietta January 1999 (has links)
Note:
44

Development of a novel methodology for the synthesis of oligonucleotide-peptide conjugates /

Zaramella, Simone, January 2004 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.
45

The synthesis of novel nucleoside analogues from nitroimidazoles

Gardner, S. J. January 1997 (has links)
No description available.
46

MD simulations of bio-nano-system: controllable translocation and selective separation of single-stranded DNAs through a polarized CNT membrane

謝迎洪, Xie, Yinghong. January 2007 (has links)
published_or_final_version / abstract / Mechanical Engineering / Doctoral / Doctor of Philosophy
47

Reduction of huntingtin aggregation and transcript levels by utilization of guanine rich oligonucleotides

Skogen, Michael John. January 2007 (has links)
Thesis (M.S.)--University of Delaware, 2007. / Principal faculty advisor: Eric B. Kmiec, Dept. of Biological Sciences. Includes bibliographical references.
48

Synthesis and oligomerization of Delta, 4-diamino-2-oxo-1(2H)-pyrimidinehexanoic acid

Huang, Sung-ben 29 May 1990 (has links)
Graduation date: 1991
49

Sorption studies of oligonucleotide DNA on montmorillonite clay : development of an improved assay protocol /

Robson, Michael H. January 2009 (has links)
Thesis (M.S.)--Texas State University--San Marcos, 2009. / Vita. Reproduction permission applies to print copy: Blanket permission granted per author to reproduce. Includes bibliographical references (leaves 68-70).
50

MicroRNA targeting with oligonucleotide analogues

Torres, Adrian Gabriel January 2012 (has links)
No description available.

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