The development of high integrity embedded systems remains an arduous and error-prone task, despite the efforts by researchers in inventing tools and techniques for design automation. Much of the problem arises from the fact that the semantics of the modeling languages for the various tools, are often distinct, and the semantics gaps are often filled manually through the engineer's understanding of one model or an abstraction. This provides an opportunity for bugs to creep in, other than standardizing software engineering errors germane to such complex system engineering. Since embedded systems applications such as avionics, automotive, or industrial automation are safety critical, it is very important to invent tools, and methodologies for safe and reliable system design. Much of the tools, and techniques deal with either the design of embedded platforms (hardware, networking, firmware etc), and software stack separately. The problem of the semantic gap between these two, as well as between models of computation used to capture semantics must be solved in order to design safer embedded systems. In this dissertation we propose a methodology for the end-to-end modeling and analysis of safety-critical embedded systems. Our approach consists of formal platform modeling, and analysis; formal application modeling; and 'correct-by-construction' code synthesis with the aim of bridging semantic gaps between the various abstractions and models required for the end-to-end system design. While the platform modeling language AADL has formal semantics, and analysis tools for real-time, and performance verification, the application behavior modeling in AADL is weak and part of an annex. In our work, we create the APECS (AADL and Polychrony based Embedded Computing Synthesis) methodology to allow an embedded system design specification all the way from platform architecture and platform components, the real-time behavior, non-functional properties, as well as the application software modeling. Our main contribution is to integrate a polychronous application software modeling language, and synthesis algorithms in order for synthesis of the embedded software running on the target platform, with the required constraints being met. We believe that a polychronous approach is particularly well suited for a multiprocessor/multi-controller distributed platform where different components often operate at independent rates and concurrently. Further, the use of a formal polychronous language will allow for formal validation of the software prior to code generation. We present a prototype framework that implements this approach, which we refer to as the AADL and Polychrony based Embedded Computing System (APECS). Our prototype utilizes an extended version of Ocarina to provide code generation for the AADL model. Our polychronous modeling language is MRICDF. Our prototype extends Ocarina to support software specification in MRICDF and generate multi-threaded software. Additionally, we implement an automated translation from Simulink to MRICDF, allowing designers to benefit from its formal semantics and exploit engineers' familiarity with Simulink tools, and legacy models. We present case studies utilizing APECS to implement safety critical systems both natively in MRICDF and in Simulink through automated translation. / Ph. D.