This study investigated the significant differences and correlations on college students' quality of life and their occupational selections. A total of 870 college students were stratified randomly selected from 15 Taiwanese colleges. All participants completed "quality of life" and "occupational selections" scales. In addition, 4 target students with either the highest total scores on quality of life or with the highest total scores on occupational selections were recruited for individual follow-up interview. Independent t-test, one-way ANOVA, and canonical correlation assessed the similarities and differences between groups. The initial findings were as follows: 1. College students¡¦ quality of life and occupational selections appear to have upper middle satisfaction and identification. 2. Female college students' mean score on the dimension of "domestic factor' was significantly higher than their male counterparts. 3. The first birth born college students' total mean on the "quality of life' and the dimension of "mental health' were significantly higher than the last birth born college students. 4. College students with high educational expectation had significantly higher mean scores on the "occupational selections", dimensions of "domestic factor' and "occupational / social factor' than these low educational expectation participants. 5. College students from mothers with high educational levels presented significantly higher means on "quality of life ' and the dimension of "occupational / social factor" than their counterparts. 6. College students from mothers with high educational levels presented significantly higher means on "quality of life', "occupational selections' and the dimension of "occupational /social factor' than their counterparts. 7. Students come from private technology colleges presented significantly higher mean scores on "quality of life', "occupational selections', and dimensions of "physical health' ,"individual factor' and "domestic factor' than their counterparts. 8. High academic achievement college students' mean scores on the "quality of life', and the dimensions of "social health' and "individual factor' were significantly higher than these low academic college students. 9. College students from high income families presented significantly higher means on the dimensions of "mental health' and "social health' than these low income families¡¦ college students. 10. There were significant canonical correlations between college students' quality of life and occupational selections. Based on these results, some educational implications and suggestions are discussed.