Dissertation (Ph.D.)--Auburn University, / Abstract. Vita. Includes bibliographic references.

Thesis (Ph. D.)--Catholic University of America. / Vita auctoris. Descriptive letterpress on versos facing the plates. Bibliography: p. 30-31.

Thesis (Ph. D.)--Catholic University of America. / Vita auctoris. Descriptive letterpress on versos facing the plates. Bibliography: p. 30-31.

Thesis (Ph. D.)--University of Chicago. / Reprinted from the Journal of comparative neurology and psychology, Volume 20, No. 2, 1910. Includes bibliographical references (p. 115-118) Also available on the Internet.

Thesis (M.S.)--University of Wisconsin--Madison. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 155-165).

The electrical activity of the olfactory bulbs of many vertebrates is characterized by large amplitude regular bursts of waves. These waves, known as induced waves, appear with each inspiration of odourous air through the nostrils. The work described in this thesis establishes that the induced waves are detectable in a variety of species investigated, from amphibia to mammalia. The occurrence of the waves under similar experimental conditions leads to the conclusion that the mechanism of their genesis is similar in all animals. The group activity of the neurones in the various layers of the olfactory bulb was studied together with the amplitude of the induced wave signal. It was found that most cellular activity occurred in the external plexiform and mitral cell layers whereas the maximum of the induced wave activity was in the granular layer. A peak of cellular activity was observed in the external plexiform and mitral cell layers with both nostrils occluded. On opening the ipsilateral nostril the cellular activity was enhanced in these same layers and on opening the contralateral nostril it was decreased. With strong olfactory stimulation an increase in the cellular activity in the granule cell layer was observed. Recordings from single olfactory neurones were made and whereas these were easily observed in the external plexiform and mitral cell layers they were found only rarely in the granule cell layer. It is proposed that the granule cell layer is the site of integration of the inhibitory influence from the contralateral olfactory bulb and from higher centres of the brain. It is further postulated that the cells in the granule cell layer do not normally generate action potentials but that they are capable of doing so with strong olfactory stimulation. It is thought that these cells are the site of genesis of the induced wave activity which is probably generated at the dendrodendritic synaptic connections with the secondary neurones. Evidence in favour of these dendrodendritic synapses being the normal pathway between the mitral and granule cells is presented. / Medicine, Faculty of / Cellular and Physiological Sciences, Department of / Graduate

published_or_final_version / Electrical and Electronic Engineering / Master / Master of Philosophy

The clustered protocadherins (Pcdh α, β & γ) provide individual neurons with cell surface diversity. However, the importance of Pcdh mediated diversity in neural circuit assembly and how it may promote neuronal connectivity remains largely unknown. Moreover, to date, Pcdh in vivo function has been studied at the level of individual gene clusters; whole cluster-wide function has not been addressed. Here I examine the role of all three Pcdh gene clusters in olfactory sensory neurons (OSNs); a neuronal type that expressed all three types of Pcdhs and in addition I address the role of Pcdh mediate diversity in their wiring. When OSNs share a dominant single Pcdh identity (α, β & γ) their axons fail to form distinct glomeruli, suggestive of inappropriate self-recognition of neighboring axons (loss of non-self-discrimination). By contrast, deletion of the entire α, β,γ Pcdh gene cluster, but not of each individual cluster alone, leads to loss of self-recognition and self-avoidance thus, OSN axons fail to properly arborize. I conclude that Pcdh-expression is necessary for self-recognition in OSNs, whereas its diversity allows distinction between self and non-self. Both of these functions are required for OSNs to connect and assembly into functional circuits in the olfactory bulb. My results, also reveal neuron-type specific differences in the requirement of specific Pcdh gene clusters and demonstrate significant redundancy between Pcdh isoforms in the olfactory system.

Thesis (Ph. D.)--Florida State University, 2003. / Advisor: Dr. Paul Trombley, Florida State University, School of Arts and Sciences, Dept. of Biological Science. Title and description from dissertation home page (viewed Feb. 26, 2004). Includes bibliographical references.

Thesis (M. Phil.)--University of Hong Kong, 2008. / Includes bibliographical references (leaf 89-92) Also available in print.