by Ida Yuk-Kit Chan. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 58-61). / Contents --- p.i / Acknowledgments --- p.ii / Abstract --- p.iii / Abbreviations --- p.iv / Chapter Chapter I. --- Introduction / Chapter 1. --- General background of dendrimers --- p.1 / Chapter 2. --- Metallodendrimers --- p.4 / Chapter 3. --- "General background of 2,2':6',2""-terpyridine complex" --- p.9 / Chapter Chapter II. --- Synthesis and Characterization / Chapter 1. --- Structure of the dendritic ligand --- p.13 / Chapter 2. --- Synthesis of the terpy-based metallodendrimers --- p.14 / Chapter 3. --- Characterization --- p.23 / Chapter Chapter III. --- Properties of Metallodendrimers / Chapter 1. --- Solubility and physical appearance --- p.29 / Chapter 2. --- UV-visible light absorption studies --- p.30 / Chapter 3. --- X-ray photoelectron spectroscopy --- p.33 / Chapter 4. --- Cyclic voltammetry studies --- p.36 / Chapter Chapter IV. --- Summary --- p.42 / Chapter Chapter V. --- Experimental --- p.43 / References --- p.58 / Spectra --- p.62

by Man-Kit Ng. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 60-69). / Contents --- p.i / Acknowledgments --- p.ii / Publications --- p.iii / Abstract --- p.iv / Abbreviations --- p.v / Chapter 1. --- Introduction / Chapter 1.1 --- General Background of Optically Active Polymers and Oligomers --- p.1 / Chapter 1.2 --- Optically Active Conjugated Polymers with Main Chain Chirality --- p.6 / Chapter 1.3 --- Optically Active Oligomers with Main Chain Chirality --- p.8 / Chapter 2. --- Design of Optically Active Oligomers with Main Chain Chirality / Chapter 2.1 --- Structure of the Oligomers --- p.11 / Chapter 2.2 --- Selection of Chiral Element --- p.11 / Chapter 2.3 --- Selection of Spacer Linkage --- p.13 / Chapter 3. --- Synthetic Routes to Optically Pure l，l'-Bi-2-naphthols / Chapter 3.1 --- Asymmetric Synthesis --- p.16 / Chapter 3.2 --- "Synthesis and Optical Resolution of l,l'-Bi-2-naphthols" --- p.19 / Chapter 4. --- Synthesis and Characterization of Optically Active Binaphthol-based Oligomers / Chapter 4.1 --- Synthesis of Enantiomerically Pure Monomer41 --- p.23 / Chapter 4.2 --- Oligomerization of the Monomer41 --- p.33 / Chapter 4.3 --- Characterization of Binaphthol-based Oligomers 41 -44 --- p.35 / Chapter 5. --- Properties of Optically Active Oligomers 41 - --- p.44 / Chapter 5.1 --- Physical Appearance and Solubility Property --- p.40 / Chapter 5.2 --- Ultraviolet Spectroscopy --- p.40 / Chapter 5.3 --- Polarimetry Studies --- p.42 / Chapter 5.4 --- Circular Dichroism Studies --- p.43 / Chapter 5.5 --- Cyclic Voltammetric Studies --- p.45 / Chapter 6. --- Conclusions --- p.48 / Chapter 7. --- Experimental --- p.49 / References --- p.60 / Spectra --- p.70

by Chi-wai Wan. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (p. 129-136). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy

by Raymond Chi-Yuen Kwong. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1995. / Includes bibliographical references (leaves 60-62). / Acknowledgements --- p.i / Abbreviations --- p.ii / Abstract --- p.iii / Chapter 1. --- Introduction --- p.1 / Chapter 2. --- Synthetic Methodology for Arylenevinylenes --- p.12 / Chapter 3. --- Result and Discussion --- p.15 / Chapter 4. --- Conclusion --- p.42 / Chapter 5. --- Experimental --- p.43 / Chapter 6. --- References --- p.60 / Chapter 7. --- Spectra

The family of oligomeric natural products derived from resveratrol possesses broad pharmacological potential, with the larger members of the class often displaying the most impressive bioactivities and the highest potencies. In particular, the trans-dihydrobenzofuran architectural motif, common to the majority of the natural materials, appears to act as a pharmacophore. Our group proposes controlled stepwise synthesis of the resveratrol derivatives to allow access to the higher-order oligomers, bypassing their inefficient isolation from natural sources. Specifically, this work focused on regioselective installation of the trans-dihydrobenzofuran motif on diverse cores. This goal was achieved by employing electrophilic aromatic substitution and directed lithiation as selective functionalization tools. A robust and broadly applicable method has been developed to allow the elaboration of the resulting functional handles into the desired structural motif.

本論文描述了一系列由銅(I)催化-疊氮-端基炔環加成反應（CuAAC）而生成並具有分子内氫鍵的AABB型共聚主鏈（酰胺-三唑）化合物，並以此研究結構上的預組織對這一系列聚合物的聚合效率、物理性質和超分子性質的影響。 / 從衍生自吡啶-2,6-二甲酰胺或對苯二甲酰對苯二胺的二炔單體61或62與具有醌二疊氮化物單體63或64共聚，可獲得一系列重復單元内含兩個分子内氫鍵並具有不同内部結構的聚（酰胺-三唑）化合物。此外，一系列結構相似但重復單元内不含分子内氫鍵的二炔單體65-69也被用於與63或64共聚以作比較。透過核磁共振光譜法，質譜法，和/或尺寸排阻排阻色譜法（SEC）的鑑定能確認所有份子的結構。通過SEC分析結果顯示，只有每個重復單元内含分子内氫鍵的單體61或62得到的相應點擊聚合物才具有較高的DP值。這些結果表示，分子間的氫鍵能增強化合物結構的剛性從而減少環狀聚合物的產生，因而提高聚合度。 / 我們還發現，這些具預組織能猶的骨架的可以提升它們的自組裝能力，並促使它們在芳香溶劑裏形成可逆的有機凝膠。我們採用傅里葉轉換紅外光譜（FTIR）、X-射線粉末衍射（XRD）和掃描電子顯微鏡（SEM）對自組裝機制進行了研究。相比之下，重復單元内不含足夠分子内氫鍵的結構類似物65-69卻不能形成凝膠。 / 最後，我們發現，含有三唑基間苯二甲酰間苯二胺或三唑基吡啶-2,6-二甲酰胺基的聚（酰胺-三唑）化合物可以利用酰胺的NH和三唑的CH形成多個可結合滷素陰離子的位點。我們先用結構更簡單的寡聚類似物113-114和118模仿滷素陰離子(氯、溴、碘)結合強度，模式和機制。結果顯示，寡聚類似物與氯離子的結合強度明顯高於溴陰離子、碘陰離子是最弱的。有趣的是，間苯二甲酰間苯二胺的類似物對滷素陰離子的結合能力比吡啶-2,6-二甲酰胺類似物高得多。表明預組織的酰胺NH和三唑CH並沒有提供明顯對陰離子結合的優勢。相反，含有氮孤對的吡啶-2,6-二甲酰胺系統對滷素陰離子的結合的不穩定性影響更突出。根據此訊息，聚合物對滷素陰離子的結合特性就能得以估計。這研究結果得出一系列少數具有陰離子封裝能力的中性聚合物。 / This thesis described the copper(I)-catalyzed alkyne-azide AABB-type copolymerization of a series of main-chain poly(amide-triazole) compounds containing intramolecular hydrogen bond motifs, with the aim of understanding the effects of hydrogen bond-promoted preorganization on polymerization efficiencies and their physical and supramolecular properties. / A dialkyne monomer, 61 or 62 derived from pyridine-2,6-dicarboxamide or terephthalamide with two intramolecular hydrogen bonds per repeating unit, were synthesized and copolymerized with a diazide monomer, 63 or 64 respectively, to give the corresponding poly(amide-triazole)s (99 and 106) with different internal architecture. For comparison purposes, structurally similar dialkyne monomers 65-69 but with only one or no intramolecular hydrogen bonds per repeating unit were also prepared and copolymerized with the same diazide monomer 63 or 64 to give polymers 100-103 and 107. All compounds were characterized by a combination of nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry, and/or size exclusion chromatography (SEC). According to SEC analysis, it was found that monomers 61-62, with two intramolecular hydrogen bonds per repeating unit gave the corresponding click polymers with higher DP values. These results indicated that the imposed structural rigidity created by the intramolecular hydrogen bonds could reduce the amount of cyclic polymers and enhance the propagation growth of the polymerization process. / It was also discovered that such a preorganization along the backbone of poly(amide-triazole)s could enhance their self-assembly process and promote the formation of thermoreversible organogels in aromatic solvents. The assembly mechanisms were investigated by Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (XRD) and scanning electron microscopy (SEM). The organogelating property was not observed in other structural analogues (100-103 and 107) that lack the sufficient number (i.e. 2 per repeating unit) of intramolecular hydrogen bonds. / Finally, it was found that poly(amide-triazole)s that contained repeating triazolyl isophthalamide or triazolyl pyridine-2,6-dicarboxamide motifs could utilize the amide NH and triazole CH groups to form multiple binding sites for halide anions. The halide (Cl⁻, Br⁻, I⁻) binding strengths, modes and mechanisms were first modeled using the structurally simpler oligomeric analogues 113-114 and 118. It was found that the binding strength of the chloride anion was higher than that of the bromide anion, and that of the iodide anion was the weakest. Interestingly, the isophthalamide analogues possessed a much higher binding ability towards anions than the pyridine-2,6-dicarboxamide analogues, suggesting preorganization of the amide NH and triazole CH groups did not offer substantial advantages towards anion binding. Rather, the destabilizing effect of the nitrogen lone pair on the pyridine-2,6-dicarboxamide system was more prominent. Based on this information, the binding properties of the polymeric analogues were then formulated. These results represent one of the few examples of a class of neutral polymers that possessed anion binding ability. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Detailed summary in vernacular field only. / Yim, Sui Lung. / Thesis (Ph.D.) Chinese University of Hong Kong, 2014. / Includes bibliographical references (leaves 150-156). / Abstracts also in Chinese.

Wei Chunmei. / "September 2000." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (p. 137-140). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Chapter one reviews the recent progress in the synthesis of phosphonopeptides, pseudopeptides containing a phosphinic, phosphonic or phosphonamide linkage in place of an amide (peptide) linkage. It describes some of the general methods for the synthesis of these pseudopeptides; for example through couplings to the nitrogen of an α-aminophosphonic acid, or Michael addition to acrylates, as well as other methods, the scope for which are not as wide yet. It also provides a summary of the reported biological activities of this class of pseudopeptides. Chapter two contains the results and discussion for a novel method for the synthesis of α-hydroxy phenylphosphinate oligomers as well as hybrid oligomers containing α-hydroxy phenylphosphinic acid and α-amino carboxylic acids. In particular, synthesis of a series of dimeric α-hydroxy phenylphosphinates are reported. The analysis of these dimers by a combination of NMR spectroscopy, X-ray crystallography and computational methods shows intramolecular hydrogen bonding in these molecules depends on the relative configuration of the carbon and phosphorus atoms. However, although the development of the synthetic methods was successful, the separation and isolation of the diastereomers was not always possible, which hindered a more comprehensive analysis of folding patterns in these molecules. Chapter three contains the experimental procedures, preparation and spectroscopic characterisation of all the chemical compounds. Crystal data and details of crystal structures are in the Appendix.

by Wong Tak Ming. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 74-77). / Contents --- p.i / Acknowledgments --- p.iii / Abstract --- p.iv / Abbreviations --- p.v / Chapter Chapter 1. --- Introduction / Chapter 1.1. --- General background on conducting polymers and oligomers --- p.1 / Chapter 1.2. --- Conjugated oligomers and polymers --- p.3 / Chapter 1.2.1 --- Theory of conducting polymers / Chapter 1.2.2 --- Oligo- and poly-(p-phenylene)s / Chapter 1.2.3 --- Oligo and poly(phenylenevinylene)s / Chapter 1.2.4 --- Oligo and poly(phenylenethynylene)s / Chapter 1.3. --- Synthesis and solubilization of structurally rigid conjugated oligomers by dendritication --- p.19 / Chapter 1.4. --- Introduction of dendrimer chemistry --- p.20 / Chapter Chapter 2. --- Results and discussion / Chapter 2.1. --- An accelerated approach to the synthesis of oligo(phenylenevinylene)s -preparation of the propagating dimeric unit72 --- p.25 / Chapter 2.2. --- Synthesis of the polyether dendritic fragments --- p.29 / Chapter 2.3. --- Attempted coupling reactions between the polyether dendrimer and the propagating unit72 --- p.32 / Chapter 2.4. --- Synthesis and characterization of dendritic-solubilized oligo-(phenylenethynylene)s (OPE) --- p.34 / Chapter 2.4.1 --- Synthesis of conjugated propagating units / Chapter 2.4.2 --- Characterization of conjugated propagating units / Chapter 2.5. --- Synthesis and characterization of dendritic-solubilized oligo-(phenylenethynylene) fragments dendrimerized at one end --- p.39 / Chapter 2.5.1 --- Synthesis / Chapter 2.5.2 --- Characterization / Chapter 2.6. --- Synthesis and characterization of oligo(phenylenethynylene)s dendrimerized at both ends --- p.43 / Chapter 2.6.1 --- Synthesis / Chapter 2.6.2 --- Purification and characterization / Chapter 2.6.3 --- Solubility and physical appearance / Chapter Chapter 3. --- Summary --- p.49 / Chapter Chapter 4. --- Experimental section --- p.50 / References --- p.74 / List of spectra --- p.78