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The effects of basin edge slope on the dynamic response of soil deposits are assessed by using one-dimensional and two-dimensional numerical analyses. 24 basin models having trapezoidal cross section are generated to represent different geometries (basin depth, basin edge slope) and soil type. Harmonic base motions with different predominant periods (Tp) are used in the analyses. The results indicate that, for a constant basin edge slope and a constant ratio of fundamental period of site to the predominant period of base motion (Tn/Tp), the response is almost the same for different soil types, basin depths and base motions. In the sloping edge region, one-dimensional response analysis predictions are found to be conservative compared to two-dimensional analysis predictions / however beyond this region they are unconservatively biased by a factor as high as 1.5. The sloping edge region and the horizontal region of the basin are denoted by normalized distance (ND) values varying from 0 to 1 and 1 to 2 respectively. The critical region where maximum amplification observed falls in the range of ND=1.0 to ND=1.5 for basins having slopes greater than 30o. The lower boundary of the critical region is shifted towards as low as ND=0.2 for basins having slopes less than 30o. For a constant value of Tn/Tp, the increase in the amplification is smooth for basins with gentle slopes as compared to basins with steep slopes for the region where ND~1. For a basin and earthquake couple approaching to resonance state (Tn/Tp=1), the amplification for the region where ND is greater than 1 is found to be as high as 100% of that is found for the region where ND~1.

The aim of this diploma thesis is the application of vibrational spectroscopy in pharmaceutical analysis in studying solid pharmaceutical forms. The surface of tablet samples containing the active substance from the group of statins has been studied especially by the methods infrared microscopy. Spectral maps of samples were collected thanks to the techniques of specular reflection, attenuated total reflection (ATR) and "inverse" ATR after determining optimal conditions for measurements. In order to evaluate these measured maps, one-dimensional analysis and principal component analysis were used. As the same samples of tablets were also measured by Raman microscopy, the comparison has been provided. The measured distribution maps enable both a determination of substances in the sample and conclusion concerned a method of tablets' preparation. The method in this case is a granulation, which has been found out from a comparison of maps of generic and original medicament. The specular reflection method was selected to be the most appropriate technique for obtaining the maps of the surface of a tablet, via confrontation of particular methods consequently with consideration of their advantages and disadvantages in the measurement and data processing.