In this thesis, the problem of online adaptive hashing for fast similarity search is studied. Similarity search is a central problem in many computer vision applications. The ever-growing size of available data collections and the increasing usage of high-dimensional representations in describing data have increased the computational cost of performing similarity search, requiring search strategies that can explore such collections in an efficient and effective manner. One promising family of approaches is based on hashing, in which the goal is to map the data into the Hamming space where fast search mechanisms exist, while preserving the original neighborhood structure of the data. We first present a novel online hashing algorithm in which the hash mapping is updated in an iterative manner with streaming data. Being online, our method is amenable to variations of the data. Moreover, our formulation is orders of magnitude faster to train than state-of-the-art hashing solutions. Secondly, we propose an online supervised hashing framework in which the goal is to map data associated with similar labels to nearby binary representations. For this purpose, we utilize Error Correcting Output Codes (ECOCs) and consider an online boosting formulation in learning the hash mapping. Our formulation does not require any prior assumptions on the label space and is well-suited for expanding datasets that have new label inclusions. We also introduce a flexible framework that allows us to reduce hash table entry updates. This is critical, especially when frequent updates may occur as the hash table grows larger and larger. Thirdly, we propose a novel mutual information measure to efficiently infer the quality of a hash mapping and retrieval performance. This measure has lower complexity than standard retrieval metrics. With this measure, we first address a key challenge in online hashing that has often been ignored: the binary representations of the data must be recomputed to keep pace with updates to the hash mapping. Based on our novel mutual information measure, we propose an efficient quality measure for hash functions, and use it to determine when to update the hash table. Next, we show that this mutual information criterion can be used as an objective in learning hash functions, using gradient-based optimization. Experiments on image retrieval benchmarks confirm the effectiveness of our formulation, both in reducing hash table recomputations and in learning high-quality hash functions.