Humidity measurement in industries is a critical factor, since it may affect the business cost of the product, end product quality, optimal functioning of equipment, and the health and safety of the personnel. Hence, humidity sensing is becoming very important, especially in the control systems for industrial processes. Since humidity is expressed in different ways, it is very difficult to come up with a reliable, consistent, and repeatable humidity measurement approach. In contrast to other sensors employed for measuring other parameters like temperature and pressure, a humidity sensor has to be in contact with the process environment and hence is difficult to implement. This research was initiated at the Diagnostic Instrumentation and Analysis Laboratory (DIAL) for the requirement from the DOE to monitor the moisture in the soil at the nuclear waste storage facility. The idea was to monitor the leakage, if any, in the storage cylinders to avoid any hazard that may come up. The humidity sensor in this case had to be able to transmit the measurement over a distance far away from the actual measurement site. Keeping all these factors in mind, a chemically deposited optical fiber humidity sensor was developed. It was based on the evanescent tail absorption of light passing through an optical fiber due to hygroscopic material deposited on it. The hygroscopic material used was an aqueous solution of Poly-vinyl-acetate (PVA) and Cobalt Chloride (COCl2). The sensor yielded a consistent humidity measurement from 75% to 95%. Based on the above research, research is currently in progress to bring up a commercial prototype of the sensor.

Two-week sampling periods during the spring, summer, and fall of 2003, and the winter of 2004 were conducted utilizing a tandem differential mobility analyzer (TDMA) and, during the spring and summer, an aerodynamic particle sizer (APS), to characterize the seasonal variability of the Big Bend regions aerosol optical properties. Mass extinction efficiencies and relative humidity scattering enhancement factors were calculated for both externally and internally mixed aerosol populations for all size distributions collected, in an effort to possibly improve upon the default EPA mass extinction efficiencies used for all Class 1 areas across the United States. The mass extinction efficiencies calculated differed to some extent form the default values employed by the EPA. Sulfate, nitrate, and light absorbing carbon (LAC) exhibited a strong dependence on assumed mixing state, while, additionally, sulfate was also dependent on the assumed dominant aerosol. Seasonal variability was seen with all particle types, excluding LAC, with sulfate mass extinction efficiencies displaying the greatest variability with season. Calculated back trajectories indicated that air masses originating from the southeast had elevated mass extinction efficiencies, while, conversely, air masses originating from the southwest and northwest had the smallest mass extinction efficiencies.

Neointimal hyperplasia, the proliferative growth of the innermost layer of the blood vessel wall, is a key process in the response to vascular injury, underlying conditions such as post-interventional restenosis and vein/arterial graft disease. One of the many mediators implicated in this process is endothelin-1 (ET-1), a potent vasoconstrictor with pro-inflammatory and pro-mitogenic actions, which acts through ETA and ETB receptor subtypes. It is well established that ET-1 increases, and ETA blockade reduces, neointima formation following vascular injury. The role of ETB is less clear because these receptors mediate potentially beneficial actions in endothelial cells (EC; such as nitric oxide production, and ET-1 clearance) but detrimental effects elsewhere (such as vascular smooth muscle) and it has been recently reported that non-cell-specific ETB deficiency is associated with increased neointimal lesion size following injury. The work described in this thesis addressed the hypothesis that endogenous ET-1 contributes to neointimal hyperplasia by activation of the ETA receptor, and that this action is moderated by concurrent activation of the ETB receptor expressed in EC. The role of ET receptors in neointimal lesion development was assessed using two models of femoral arterial injury in the mouse: (i) an established method of intraluminal wire-injury, and (ii) adaptation of a model of ligation injury that induces robust neointimal lesion formation without physical damage to the endothelium. Lesion development was assessed using standard histological techniques and this was augmented by development of quantitative optical projection tomography (OPT) to allow three-dimensional analysis of lesions. The role of ETA and ETB receptors in these models was addressed using suitable pharmacological ET receptor antagonists. Following wire-injury, selective ETB blockade (A192621; 30mg.kg-1.day-1; 35 days) increased lesion size and blood pressure without significant altering lesion composition. In contrast, selective ETA blockade (atrasentan; 10mg.kg-1.day-1; 35 days) reduced lesion size and blood pressure. Combined ETA+ETB antagonism had no effect on lesion size, despite reducing blood pressure, and reducing collagen content of the lesions. In the ligation model, neither ETA selective, ETB selective nor ETA+ETB blockade altered lesion size as assessed by standard histology but analysis by OPT indicated that ETA blockade, with or without concurrent ETB blockade, reduced lesion volume. The influence of ETB receptors expressed by ECs on lesion formation was addressed using EC-specific ETB knockout mice. Small vessel myography indicated that endothelium-dependent relaxation was unaltered in femoral arteries from these mice. In addition, no effect on lesion size or rate of development was observed in either wire- or ligation-injury models of neointima formation (although subtle effects on lesion and medial composition were apparent after intra-luminal injury). These results indicate that ETB receptor activation can moderate the detrimental actions of the ETA receptor on neointimal lesion progression, and that this role is dependent on the mode of vascular injury. Furthermore, in this setting, this beneficial action is not primarily mediated by ETB expressed by EC, suggesting that ETB in other cell types can reduce lesion development through another, unidentified mechanism. Therefore, while both ETA selective and non-selective ETA/B antagonists are currently in clinical use, in conditions where similar arterial remodelling processes occur, selective ETA receptor antagonists might be preferred.

The growing demand for wireless communication capacity and the overutilisation of the conventional radio frequency (RF) spectrum have inspired research into using alternative spectrum regions for communication. Using optical wireless communications (OWC), for example, offers significant advantages over RF communication in terms of higher bandwidth, lower implementation costs and energy savings. In OWC systems, the information signal has to be real and non-negative. Therefore, modifications to the conventional communication algorithms are required. Multicarrier modulation schemes like orthogonal frequency division multiplexing (OFDM) promise to deliver a more efficient use of the communication capacity through adaptive bit and energy loading techniques. Three OFDM-based schemes – direct-current-biased OFDM (DCO-OFDM), asymmetrically clipped optical OFDM(ACO-OFDM), and pulse-amplitude modulated discrete multitone (PAM-DMT) – have been introduced in the literature. The current work investigates the recently introduced scheme subcarrier-index modulation OFDM as a potential energy-efficient modulation technique with reduced peak-to-average power ratio (PAPR) suitable for applications in OWC. A theoretical model for the analysis of SIM-OFDMin a linear additive white Gaussian noise (AWGN) channel is provided. A closed-form solution for the PAPR in SIM-OFDM is also proposed. Following the work on SIM-OFDM, a novel inherently unipolar modulation scheme, unipolar orthogonal frequency division multiplexing (U-OFDM), is proposed as an alternative to the existing similar schemes: ACO-OFDMand PAM-DMT. Furthermore, an enhanced U-OFDMsignal generation algorithm is introduced which allows the spectral efficiency gap between the inherently unipolar modulation schemes – U-OFDM, ACO-OFDM, PAM-DMT – and the conventionally used DCO-OFDM to be closed. This results in an OFDM-based modulation approach which is electrically and optically more efficient than any other OFDM-based technique proposed so far for intensity modulation and direct detection (IM/DD) communication systems. Non-linear distortion in the optical front-end elements is one of the major limitations for high-speed communication in OWC. This work presents a generalised approach for analysing nonlinear distortion in OFDM-based modulation schemes. The presented technique leads to a closed-form analytical solution for an arbitrary memoryless distortion of the information signal and has been proven to work for the majority of the known unipolar OFDM-based modulation techniques - DCO-OFDM, ACO-OFDM, PAM-DMT and U-OFDM. The high-speed communication capabilities of novel Gallium Nitride based μm-sized light emitting diodes (μLEDs) are investigated, and a record-setting result of 3.5Gb/s using a single 50-μm device is demonstrated. The capabilities of using such devices at practical transmission distances are also investigated, and a 1 Gb/s link using a single device is demonstrated at a distance of up to 10m. Furthermore, a proof-of-concept experiment is realised where a 50-μm LED is successfully modulated using U-OFDM and enhanced U-OFDM to achieve notable energy savings in comparison to DCO-OFDM.

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