With the rapid growth of load demand, the distribution system is becoming very complicated such that the operation efficiency and service quality are deteriorated during recent years. Engineers have to solve the problems by applying new technologies to enhance the efficiency of distribution system. In this thesis, an immune algorithm(IA) based on weighting selection as a decision maker is proposed to reach the desired switching operations such that transformer and feeder loading balance can be achieved. The IA antigen and antibody are equivalent to the objective and the feasible solution for a conventional optimization method. The concept of the information entropy is also introduced as a measure of diversity for the population to avoid falling into a local optimal solution. This algorithm prevents the possibility of stagnation in the iteration process and achieves the fast convergence for the global optimization. With the object-orient programming(OOP), this research project is to create the relationship of distribution element objects and encapsulation of data with all 22KV underground systems in Taichung district. The OOP does provide an effective tool for the management of distribution system database and the fault detection, isolation, and service restoration(FDIR) function of feeders and main transformers. According to the attributes of line switches, we can create the 22KV distribution system configuration with the topology processor. In order to calculate the current flows of line switches, this project will also execute the three phase load flow program with the customer information system(CIS), load survey, outage management information system(OMIS), and the data of all feeders and main transformers. In this thesis, the IA is used to solve the optimal switching problem by considering the customer load characteristics for the normal operation and the overload contingency of the distribution system. The efficiency of immune algorithm to solve the problem is verified by comparing to the computing time of the conventional binary integer programming for decision making of switching operation. A Taichung district distribution system is selected for computer simulation to demonstrate the effectiveness of the proposed methodology for solving the optimal switching operation of distribution system. The result of this thesis will be an important reference for distribution automation in Taiwan.