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Optimal Control Theory and Estimation of Parameters in a Differential Equation Model for Patients with LupusAgaba, Peter 01 April 2019 (has links)
System Lupus Erythematosus (SLE) is a chronic inflammatory autoimmune disorder that affects many parts of the body including skin, joints, kidneys, brains and other organs. Lupus Nephritis (LN) is a disease caused by SLE. Given the complexity of LN, we establish an optimal treatment strategy based on a previously developed mathematical model.For our thesis work, the model variables are: Immune Complexes (I), Pro-inflammatory mediators (P), Damaged tissue (D), and Anti-inflammatory mediators (A). The analysis in this research project focuses on analyzing therapeutic strategies to control damage using both parameter estimation techniques (integration of data to quantify any uncertainties associated with parameters) and optimal control with the goal of minimizing time spent on therapy for treating damaged tissue by LN.
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Development and Implementation of Network Level Trade-off Analysis tool in Transportation Asset ManagementBam, Prayag January 2017 (has links)
No description available.
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