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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

REACTIONS OF 5-ALKYLPENTACHLORO CYCLOPENTADIENES. APPLICATIONS TO TERPENE SYNTHESIS

Sobczak, Ronald Lee, 1946- January 1976 (has links)
No description available.
2

Synthesis and chemistry of 5H-1,4,2-dithiazoles and 1,4,2-dithiazoliumsalts

衛國輝, Wai, Kwok-fai. January 1991 (has links)
published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy
3

ALKYLATION AND OXIDATIONS OF SYMMETRICAL DIMETHYLENEBIPHENYL AND RELATED DIANIONS (CYCLOPHANE, BIPHENYLOPHANE, NMR, CONFORMATION).

WHITE, JAMES JEFFREY. January 1986 (has links)
Bis-benzyl dianions were prepared from the three symmetrical dimethylbiphenyls in yields of 79-86%, and shown to react with a variety of electrophiles on the benzylic carbons. Electrophiles included dimethyl and diethyl sulfate, isopropyl bromide, t-butyl iodide, allyl chloride, trimethylsilyl chloride, trimethylgermyl bromide, and trimethyltin chloride. Reaction of the dianions with (alpha),(omega)-dihalides provides an excellent route to n.0 - and n.0.n.0 cyclophanes. An X-ray study on 14.0 paracyclophane showed it to have a conformation different from that observed in solution by NMR; MM2 calculations were used in determining what the solution conformation is likely to be. Oxidation of the dianions produced the monomer dihydrophenanthrene from the ortho isomer, dimer 2.0.2.0 metacyclophane from the meta isomer, and polymer from the para isomer. An X-ray study on 2.0.2.0 metacyclophane showed it to have the same conformation in the crystal as is observed in solution by NMR. An NMR method for determining the angle of twist in a biphenyl based on the chemical shift of the ortho hydrogens was developed. Many oxidizing agents were evaluated for the oxidation of the dianion from 2,3-dimethyl-1,3-butadiene to 1,2,5,6-tetramethylenecyclooctane; cupric bromide was found to be the best.
4

SYNTHESIS OF CHIRAL LIPIDS. APPLICATIONS TO THE SPECIFICITIES OF LIPOLYTIC ENZYMES.

KANDA, PATRICK. January 1984 (has links)
In this study, synthetic routes to certain short acyl chain phospholipids were developed. Their inhibitory or substrate properties for phospholipase A₂ were then examined. An improved method for the acylation of glycerophosphocholine is described using a mixed fatty acid - trifluoroacetic acid anhydride. This partial synthetic route is particularly suitable for obtaining short acyl chain phosphatidylcholines. A new pathway for constructing the unnatural sn-1-phosphatidylcholines is also described, starting from L-arabinose. This is converted first to a key intermediate, 2,3-O-isopropylidene-sn-glycerol, which is then phosphorylated and transformed into sn-glycero-1-phosphocholine. This can be acylated as above to give sn-1-phosphatidylcholines. Routes to the short chain phosphatidylethanolamines were investigated and discussed. A procedure, using phospholipase D, was used to convert L-diC₆ PC into L-diC₆ PE in a transphosphatidylation reaction. Failed attempts to obtain shorter chain homologs by this and other methods are also detailed. The kinetics of inhibition of the phospholipase A₂ hydrolysis of L-diC₆ PC by the D-isomer are also reported for the monomeric concentration range. It was found that the D- enantiomer did not behave as a pure competitive inhibitor, and that an enzyme-substrate-inhibitor complex can exist. The implications of these results with regard to PLA₂ hydrolysis of mixed micelles is discussed. The PLA₂ substrate properties of both the anionic and zwitterionic diC₆ PE's were also studied. It was established that the anionic diC₆ PE is either a very poor substrate relative to the zwitterionic diC₆ PE, or acts as a competitive inhibitor towards its hydrolysis. Similarly, the rates of base-catalyzed acyl ester hydrolysis are about 18 times greater for the zwitterionic than for the anionic diC₆ PE. The importance of a protonated amino group in both these hydrolyses studies is noted. In addition, certain physical properties of diC₆ PE, such as its critical micelle concentration and carbon-13 NMR spectrum, are also given.
5

Synthesis and antimicrobial screening of some C-4- hydroxybenzo[c]pyranquinones

Masenya, Tebogo January 2001 (has links)
Thesis (MTech(Chemistry))--Cape Technikon, Cape Town, 2001 / Many naturally occurring antibiotics have been identified and their synthesis successfully carried out in laboratories. It was envisaged by our group that by preparing a variety of, for example, quinoid compounds and then comparing their biological properties and activities, a better insight would be gained into a molecular structure - activity relationship. Chapter 1 deals with the attempted synthesis of 2-(1 '-hydroxyethyl)-3-(prop-2'enyl)- 1,4-benzoquinone (17) which may be converted by known methods into benzopyran derivatives. The second chapter describes a synthetic route to (±)(3R, 4R)-3,4-dihydro-3methyl- 4-hydroxy-l H-benzo[c]pyran-5,8-dione (42) and its (±)(45) diastereomer (43), both of which were found to be active against Gram negative and Gram positive organisms. The trans-l,3-dimethyl-4-hydroxypyranquinones (45) and (46) were also successfully synthesised. A different route of synthesis for the compounds (53), (54), (55) and (56) was also investigated. Several compounds were evaluated for biological activity. It was found that the quinones synthesised during this study were active against Gram negative and Gram positive bacteria, with the exception of compound (25) which had an acetate group in place of a hydroxy group. It was found that this trend was carried through all of the quinone derivatives tested.
6

Generation of dihalocarbene by the reaction of dimethyl sulfone-potassium hydroxide-t-butanol with carbon tetrahalide.

January 1984 (has links)
by Chi-Duen Poon. / Bibliography: leaves 47-51 / Thesis (M.Ph.)--Chinese University of Hong Kong, 1984
7

A new version of the Ramberg-Bäcklund reaction and its applications in organic synthesis.

January 1993 (has links)
by Yu Li. / Thesis (Ph.D.)--Chinese University of Hong Kong, 1993. / Includes bibliographical references (leaves 97-104). / Acknowledgements --- p.i / Content --- p.ii / List of Schemes --- p.iii / List of Tables and Figures --- p.v / List of Spectra --- p.vi / Abstract --- p.ix / Chapter I. --- Introduction --- p.1 / Chapter I.1. --- The Conventional Ramberg-Backlund Reaction --- p.2 / Chapter I.2. --- The Meyers' Modification of the Ramberg-Backiund Reaction --- p.10 / Chapter II. --- The Evolution of a New Version of the Ramberg-Backiund Reaction: The Development of the Reagent KOH/A12O3- t-BuOH-CBr2F2 --- p.20 / Chapter III. --- Synthetic Applications of the New Version of the Ramberg- Backiund Reaction --- p.31 / Chapter III.1. --- "The Formation of Alkenes from α,α'-Hydrogen-containing Sulfones by Treatment with KOH/Al203-t-BuOH-CBr2F2" --- p.31 / Chapter III.2. --- Synthesis of (±)-Muscone from [12]Metacyclophane --- p.44 / Chapter III.3. --- A Non-pyrolytic Route to Corannulene --- p.49 / Chapter IV. --- Conclusion --- p.61 / Chapter V. --- Experimental --- p.62 / Chapter VI. --- References --- p.97 / Chapter VII. --- Spectra
8

An approach to the synthesis of avicennin.

January 1972 (has links)
Thesis (M.Sc.)--The Chinese University of Hong Kong. / Bibliography: leaves 90-96.
9

Synthesis of 2, 7 - Dimethylpyrene.

January 1973 (has links)
by Ho Kam Wah. / Thesis (M.Sc.)--The Chinese University of Hong Kong, 1973. / Bibliography: leaves 32-34. / Acknowledgements --- p.ii / Summary --- p.iii / Introduction --- p.1 / Synthetic Plans --- p.2 / Results and Discussion --- p.9 / Experimental --- p.22 / References --- p.32
10

A new approach to the synthesis of bridged [14] annulenes.

January 1979 (has links)
Kuan Pui Kei. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1979. / Bibliography: leaves 53-55.

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