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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Efeitos do etanol sobre a mucosa e osso palatinos do rato durante a lactação: estudo histopatológico e histométrico experimental.

Kassis, Elias Naim 11 February 2011 (has links)
Made available in DSpace on 2016-01-26T12:51:31Z (GMT). No. of bitstreams: 1 eliasnaimkassis_tese.pdf: 1206838 bytes, checksum: 890b2f6915170e129c35065467aeb0f2 (MD5) Previous issue date: 2011-02-11 / The ingestion of alcohol by a mother during lactation changes the composition of the milk, resulting in the origin of ethanol and acetaldehyde in the milk, and turns more severe the effects of the ethanol in infant rats. Objective: This work aimed to study the effects of ethanol at the palatine bone and palatine epithelium of young infants in 21 days of postnatal life, administered to the experimental rats during lactation. Materials and Methods: The experimental rats received ethanol at 20% in the drinking fountain ad libitum during those 21 day of nursing. Another group of animals received an amount of water similar to that group without ethanol. The infant rats were put to death with an extra dose of anesthesia in their 21 days of life. Their heads were separated from their body, put in 85mls of a 80% alcohol solution, 10 ml of formalin and 5ml of acetic acid, the palate area was cut in serial sections by frontal plans, in the same level were the molar are located, the cuts were about 6 micrometers and were treated with hematoxylin-eosin. The nuclear parameters of the palate epithelium, the cytoplasmatic volume and cellular, the relation nucleon/cytoplasm, numerical density and superficial, the thickness of the epithelium were all estimate. The average body weight of the infant rats in the ethanol group was 20,20 g and the other group average weight was 34,86gr. Histologically, the palate epithelium was thinner and it had more numbers of smaller cells with a bigger nucleon. The palate bone had more delicate and less trabeculo calcificated, and smaller osteocyte. Conclusion: In this experiment, the ethanol induced a epithelial hypotrophy condition and palate bone more delicate and less calcificated, showing a direct affect in the cells and trabeculo palate and also the poor development of the intoxicated infant rats. / A ingestão materna de etanol durante a lactação altera a composição do leite, resulta no aparecimento do etanol e acetaldeído no leite, e exacerba os efeitos do etanol nos filhotes da rata. Objetivo: Este trabalho teve o objetivo de estudar os efeitos do etanol, ao epitélio palatino e osso palatino de filhotes lactantes em 21 dias de vida pós-natal, administrados nas ratas-mães durante a lactação. Materiais e Métodos: Para tal, foram utilizadas ratas que receberam etanol a 20% no bebedouro ad libitum durante os 21 dias de lactação. Os animais controles receberam um volume similar de água sem álcool. Os filhotes foram sacrificados com sobre dosagem anestésica no 21º dia. As cabeças foram separadas, fixadas em solução fixadora de álcool 80%- 85ml, formalina- 10 ml e ácido acético- 5ml, a região palatina foi seccionada seriadamente em planos frontais, ao nível dos molares, e os cortes de 6 micrometros foram tratados com hematoxilina-eosina . Os parâmetros nucleares do epitélio palatino foram estimados, assim como os volumes citoplasmáticos e celulares, relação núcleo/citoplasma, densidades numérica e superficial, e espessura epitelial. O peso corporal médio do filhote foi de 34,86 g no grupo controle e 20,20 g no tratado. Histologicamente, o epitélio palatino mostrou-se mais adelgaçado, constituído de células abundantes e menores com núcleos maiores. O osso palatino mostrou trabéculas mais delicadas e menos calcificadas e com osteócitos de menor tamanho. Conclusões: Neste experimento, o etanol, induziu no quadro de hipotrofia epitelial e osso palatino mais delicado e pouco calcificado, indicando uma ação direta nas células e trabéculas do palato, além de retardar o desenvolvimento de filhotes intoxicados.

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