Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.

Thesis (M.Sc.). / Written for the Dept. of Human Genetics. Title from title page of PDF (viewed 2008/07/30). Includes bibliographical references.

Thesis (M.Sc.). / Written for the Division of Experimental Medicine. Title from title page of PDF (viewed 2008/12/04). Includes bibliographical references.

Thesis (Ph. D.)--School of Dentistry. University of Missouri--Kansas City, 2003. / "A dissertation in oral biology and molecular biology and biochemistry." Advisor: Jian Q. Feng. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed July 16, 2008. Includes bibliographical references (leaves 109-121). Online version of the print edition.

Thesis (M.S.)--University of Michigan, 1998. / Includes bibliographical references.

Thesis (Ph. D.)--University of Nebraska Medical Center, 1999. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from PDF title page (viewed on July 19, 2010). Includes bibliographical references.

Thesis (Ph. D.)--Case Western Reserve University, 2005. / [School of Medicine] Department of Pharmacology. Includes bibliographical references. Available online via OhioLINK's ETD Center.

Thesis (Ph. D.)--University of Nebraska Medical Center, 1999. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Orientador: Luana Marotta Reis de Vasconcellos / Banca: Luciane Dias de Oliveira / Banca: Sandra Giacomin Schneider / Resumo: O objetivo neste estudo foi avaliar in vitro a influência da liga Ti-35Nb-7Zr e de seus elementos básicos, submetidos ou não ao processo de oxidação, na atividade de osteoblastos e na formação de biofilmes monotípicos. As amostras foram confeccionadas com diferentes materiais: a) titânio puro (Ti - controle); b) liga Ti-35Nb-7Zr (L); c) Nb (nióbio); d) Zr (zircônio); e) Ti oxidado (TiO); f) liga Ti-35Nb-7Zr oxidada (LO); g) Nb oxidado (NbO); h) Zr oxidado(ZrO). Previamente ao estudo in vitro, todas as amostras foram caracterizadas por microscopia eletrônica de varredura (MEV) e espectroscopia de dispersão de energia (EDS) para observar a topografia de superfície e a presença dos elementos básicos. Células mesenquimais obtidas de fêmures de rato, após diferenciação em osteoblastos foram cultivadas sobre as amostras. Após períodos pré-determinados, foram realizados os testes de citotoxicidade, atividade de fosfatase alcalina, produção de proteína total, formação e quantificação dos nódulos de mineralização adesão e proliferação celular. Para análise da formação dos biofilmes monotípicos, suspensões padronizadas (106 céls/mL) com micro-organismos de S. aureus, S. mutans, P. aeruginosa e C. albicans foram cultivados por 24 h sobre as amostras e submetidos ao teste de MTT. Todas as amostras permitiram o espraiamento celular. O Nb e Zr exibiram uma adesão celular mais madura com prolongamentos celulares evidenciados. O Ti e a L apresentaram maior viabilidade celular sendo estatísti... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The objective of this study was to evaluate in vitro the influence of the Ti-35Nb- 7Zr alloy and its basic elements, whether or not subjected to the oxidation process, on the osteoblast activity and on the formation of monotypic biofilms. The samples were made with different materials: a) pure titanium (Ti - control); B) Ti-35Nb-7Zr (A) alloy; C) Nb (niobium); D) Zr (zirconium); E) Oxidized Ti (TiO); F) oxidized Ti-35Nb-7Zr (AO); G) Nb oxidized (NbO); H) Oxidized Zr (ZrO). Prior to the in vitro study, all samples were characterized by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) to observe the surface topography and the presence of the basic elements. Mesenchymal cells obtained from mouse femurs after differentiation into osteoblasts were cultured in the samples. After pre-determined periods, cytotoxicity tests, alkaline phosphatase activity, total protein production, formation and quantification of the mineralization nodules, adhesion and cell proliferation were performed. To analyze the formation of monotypic biofilms, standardized suspensions (106 cells / ml) with S. aureus, S. mutans, P. aeruginosa and C. albicans microorganisms were cultured for 24 h on the samples and submitted to the MTT test. All samples allowed for cell spreading. Nb and Zr exhibited more mature cell adhesion with evidenced cell extensions. The Ti and A presented greater cell viability being statistically different from the others (p <0.05). ZrO presented lower viability exhibiting statistical difference with Ti and A. The NbO expressed the highest amount of total protein with a statistical difference of L, Zr, and AO (p <0.05) while Zr showed the lowest result with a statistical difference of Ti, Nb, TiO, NbO, and ZrO. In the quantification of the alkaline phosphatase activity, the Zr presented the best result and was statistically different from all the others ..... (Resumo completo, clicar acesso eletrônico abaixo) / Mestre