Made available in DSpace on 2013-01-07T15:54:58Z (GMT). No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 13.pdf: 579876 bytes, checksum: 596886f72f764e7ca19ca6fe16198834 (MD5) Previous issue date: 2005 / O presente trabalho aborda a conjuntura histórica que propiciou o surgimento da osteopatia. O processo de transformação da medicina ocidental, e mais especificamente a americana, no decorrer do século XIX. Aborda também a medicina do Oeste americano, e a oposição dos grupos alternativos à medicina oficial dos EUA. Examina as principais propostas terapêuticas geradas no momento, criando um paralelo entre estas e a osteopatia. Procura identificar as principais correntes teóricas que possivelmente embasariam o pensamento de Andrew Taylor Still, além de apresentar a sua própria teoria.

M.Tech. / Purpose: The aim of this study was to compare the effects of Chiropractic adjustments to Muscle Energy Technique (MET) with regards to pain, disability and range of motion in the cervical spine. Method: Thirty participants, male or female between the ages of 18 and 55 years, diagnosed with cervical facet syndrome were used in the study. The thirty participants were randomly divided into two groups consisting of fifteen individuals each, ensuring equal male to female and age ratios. Group A received Chiropractic adjustment/s over the restricted joint/s to the cervical spine. Group B received MET to the cervical spine.The trial consisted of seven visits over a treatment period of three weeks, of which the first six visits the participants received treatment and the seventh visit served the purpose of obtaining the final data. The data was gathered on the first, fourth and seventh visits. The data was always gathered before the treatment was performed. Objective data consisted of measuring cervical spine range of motion with a CROM instrument. Subjective data was obtained by using the Numerical Pain Rating Scale (NPRS) and the Vernon-Mior Neck Pain and Disability Index. Results: The results indicated that Group A (Chiropractic adjustments) proved to be the most effective treatment protocol. Although the other treatment protocol, Group B (Muscle Energy Technique), also showed good results. Both subjective and objective results showed that although Group B produced statistically significant results, Group A showed the best results overall. Thus it was noted that in order to achieve a potentially lasting increase in range of motion and a decrease in pain and disability, the treatment protocol used for Group A should be the treatment of choice. Conclusion: It was concluded, based on the results, that Chiropractic adjustments was more effective than MET in the treatment of cervical facet syndrome. This conclusion is based on the results that Chiropractic adjustments was more effective in all the objective and all the subjective measurements. However, this does not rule out MET as a treatment for neck pain, because MET treatment did show improvements in cervical spine ROM and a decrease in pain, although not as efficiently as Chiropractic treatment.

This pre-conference workshop is designed to provide a foundation in osteopathic principles and practice and basic skills in osteopathic diagnosis and manipulative treatment for medical students, residents and family medicine faculty with little to no training in osteopathic medicine. It is also an excellent opportunity for doctors of osteopathic medicine (DOs) to refresh their skills. Upon completion of this session, participants should be able to: Understand the four tenets of osteopathic medicine and their applicability to allopathic as well as osteopathic medicine. Demonstrate the basic osteopathic assessment and treatment of 3–4 common diagnoses that present in outpatient and inpatient family medicine settings. Produce an outline of a training curriculum in osteopathic assessment and treatment for non-DOs within his/her own program using the tools provided by the workshop.

Bone has several crucial functions including mechanical support of movement, hematopoiesis, maintenance of mineral homeostasis, and energy regulation. Bone also undergoes continuous remodeling to maintain its structural integrity, which suggests it has strong respiration and energy consumption capability. It has been shown that during development, bones, in particular, osteoblasts, rely on glucose uptake for proper skeletal development. However, the effect of energy utilization on osteocytes’ function is currently unknown. Osteocytes are terminally differentiated osteoblasts and are deeply embedded into the mineralized matrix of bone. Previous studies have shown that PTH promotes bone anabolism, in part, by stimulating osteoblasts anaerobic glycolysis while suppressing glucose oxidation through the TCA cycle. In osteocytes, PTH suppresses Sost expression (the gene encoding a potent inhibitor of bone formation) by inducing HDAC4/5 nuclear translocation and MEF2C inhibition. Recently, Scriptaid, an HDAC complex inhibitor, has been shown to induce Mef2 expression and exercise-like adaptation in mouse muscles. In myocytes, Scriptaid disrupts the HDACs co-repressor complex and induces nuclear export of HDAC4/5 with MEF2 activation. This will subsequently increase the expressions of several genes related to energy utilization such as Glut4 and Pdk4. Thus we hypothesized that Scriptaid might regulate Sost and Glut4 expression in osteocytes. To investigate the effect of Scriptaid on osteocytes, we treated a mouse osteocytic cell line, Ocy454-12H, with Scriptaid. Unexpectedly, Scriptaid potently suppressed Sost, whereas it increased Glut4 expression. Scriptaid stimulated osteocyte respiration and glucose consumption rate. Mechanistically, Scriptaid treatment of Ocy454-12H induced nuclear translocation of Hdac5 whereas it did not affect Hdac4. Silencing of Hdac5 expression with shRNA increased Sost basal expression and blocked Sost suppression induced by Scriptaid. However, Glut4 up-regulation by Scriptaid was independent of the HDAC4/5-MEF2C pathway. Glut4 luciferase reporter assays demonstrated that two additional transcription factors binding sites, O/E&NF1 and C/EBPα, may mediate Scriptaid-induced Glut4 up-regulation. Taken together, these data demonstrate that in osteocytes Scriptaid suppresses Sost expression through regulating HDAC5-MEF2C signaling. However, Scriptaid increases Glut4 expression through Hdac5-independent mechanisms, and dependent on O/E&NF1 and C/EBPα.

No description available.

Thesis (M.Ost.)--Unitec New Zealand, 2008. / Includes bibliographical references (leaves 92-99).

Introduction The use of Patient Reported Outcome Measures (PROMs) to measure the effects of care is being advocated increasingly in clinical settings. Current patient data capture involves completion of paper questionnaires which is costly and environmentally perplexing. New innovations are required to balance the challenges of introducing data capture directly from patients while considering budgets, access to Information Technology, and the capability to use technological devices. Methods Two qualitative studies were undertaken to identify the views of patients and clinicians concerning electronic PROM data capture in osteopathic practice. One qualitative study involved patient interviews to identify their views on a selection of specific PROMs. Clinician focus groups and interviews (osteopaths, chiropractors, and physiotherapists) were undertaken concerning their views and experiences of using PROMs. Scoping of PROMs in musculoskeletal practice was undertaken followed by a systematic review of one identified PROM. The review and qualitative work informed the development of content for a mobile and web app for capturing PROM data. The app was piloted to evaluate feasibility, and the clinimetric performance of the included PROMs. Feedback from the pilot informed revisions to the app prior to implementation into osteopathic practice. Results Clinicians (n=46) identified a range of barriers and facilitators to PROM use. Patients (n=22) while generally more enthusiastic than clinicians welcomed the opportunity to provide feedback and although undaunted by the use of technology highlighted the need for assurances concerning confidentiality of data, and limits on data sharing. The systematic review identified good measurement properties for the Bournemouth (BQ). Piloting of the app involved 257 participants contributing 404 data returns: it performed well requiring minimal revision prior to implementation. Conclusions The app performed well demonstrating great potential for further development to collect outcome data in a musculoskeletal clinical setting.

The book distills the available information on osteoporosis into an easily comprehensible format that serves as a practical guide for busy clinicians. Contents:Definition & epidemiology -- Basic bone pathophysiology -- Bone densitometry -- Diagnosis -- Identifying patients at risk of fractures -- Non-pharmacologic management of osteopenia and osteoporosis -- Pharmacologic management of osteoporosis, part 1 -- Pharmacologic management of osteoporosis, part 2 -- Monitoring patients on treatment -- Vertebral augmentation procedures -- Corticosteroid-induced bone loss -- Primary hyperparathyroidism -- Premenopausal women -- Men -- Atypical femoral shaft fractures -- Osteonecrosis of the jaw -- Osteoporosis in children and adolescents. / https://dc.etsu.edu/etsu_books/1077/thumbnail.jpg

Summary: The FRAX algorithm assesses the patient’s probability of sustaining an osteoporotic fracture and can be calculated with or without densitometric data. This study seeks to determine whether in men, FRAX scores calculated without BMD, correctly identify patients with BMD-defined osteoporosis. Introduction: The diagnosis of osteoporosis is based on densitometric data, the presence of a fragility fracture or increased fracture risk. The FRAX algorithm estimates the patient’s 10-year probability of sustaining an osteoporotic fracture and can be calculated with or without BMD data. The purpose of this study is to determine whether in men, FRAX calculated without BMD, can correctly identify patients with BMD-defined osteoporosis. Methods: Retrospectively retrieved data from 726 consecutive Caucasian males, 50 to 70 years old referred to our Osteoporosis Center. Results: In the population studied, 11.8 and 25.3% had BMD-defined osteoporosis when female and male reference populations were used respectively. When the National Osteoporosis Foundation thresholds to initiate treatment are used, only 27% of patients with BMD-defined osteoporosis, but 4% with normal BMD reached/exceeded these thresholds. Lowering the threshold increased sensitivity, but decreased specificity. Conclusions: Our results suggest that FRAX without BMD is not sensitive/specific enough to be used to identify Caucasian men 50 to 70 years old with BMD-defined osteoporosis.

Thesis (M.Ost.)--Unitec New Zealand, 2008. / Coda (electronic version) title-page has 2009 date. Includes bibliographical references (leaves 38-47).