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Endotoxin protection of rats from oxygen toxicity : role of lung phagocytesBerg, John Townsend January 1985 (has links)
Typescript. / Thesis (Ph. D.)--University of Hawaii at Manoa, 1985. / Bibliography: leaves 82-92. / Microfilm. / vii, 92 leaves, bound ill. 29 cm
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Oxygen toxicity in Campylobacter jejuni: physiological comparison of a microaerophilic wild-type strain with an aerotolerant mutantVercellone, Pamela Ann 21 November 2012 (has links)
A comparative study of the microaerophilic <u>Campylobacter jejuni</u> strain H840 with an aerotolerant mutant, MC711-01, revealed that catalase and, to a lesser extent, SOD activity is correlated with the aerotolerance and enhanced resistance of MC7ll-0l to H₂O₂. When cells were cultured under 6% oxygen, the specific activity of catalase was significantly higher in crude extracts of MC711-01 than of H840. The catalase activity of MC711-01 more than doubled when cells were cultured under 21% oxygen, and this activity was 2.6 times greater than that of H84O; no corresponding increase was observed in strain H840. There was no significant difference in the mean SOD activity of the two strains when cultured under 6% oxygen or in H840 cells cultured under either 6% or 21% oxygen; however, the SOD activity of MC711-01 increased 1.5 times when cells were cultured under 21% oxygen.
Survival studies revealed that MC711-01 was significantly more E resistant to H₂O₂ when cultured under either 6% or 21% oxygen. However, both MC711-01 and H84O were more susceptible to H₂O₂ when grown under 21% oxygen, indicating that both strains might be more highly stressed when the cells are grown at this oxygen tension.
The present study suggests that in <u>C. jejuni</u>, the level of catalase activity may influence the degree of susceptibility to H₂O₂ and consequently, the degree of aerotolerance. / Master of Science
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