Thèse (M.Sc.)--Université Laval, 2006. / Titre de l'écran-titre (visionné le 18 sept. 2007). Bibliogr.

La recrudescence de maladies infectieuses et le nombre grandissant de bactéries résistantes aux antibiotiques sont des problèmes majeurs de santé publique. Ainsi, le développement d’une nouvelle catégorie d’agents antimicrobiens est de plus en plus pressant. Nous nous sommes tournés vers les bactériophages afin d’en connaître davantage sur les moyens qu’ils utilisent pour tuer les bactéries. Cependant, jusqu’à maintenant il existe très peu de connaissances sur leur activité bactéricide. Nous avons donc caractérisé le mode d’action de la protéine de lyse P1 du phage AP205 à l’aide d’approches in vitro et in vivo. Ce phage a pour hôte Acinetobacter. La protéine P1 cible un élément essentiel à la survie bactérienne, la paroi de peptidoglycane. En fait, nous avons découvert qu’elle inhibe plusieurs enzymes impliquées au niveau de cette voie synthèse. Nous espérons que les connaissances acquises sur cette protéine antibiotique contribueront au développement d’une nouvelle classe d’agents antimicrobiens. / The constant increase of infectious diseases and bacterial resistance to antibiotics are major problems of public health. Thus, development of a new class of antimicrobial agents is very urgent. We have decided to explore bacteriophages to learn more about the way they kill bacteria. Therefore, until now, the knowledge about this bactericidal activity is limited. We have characterized the inhibition mechanism of P1 lysis protein from phage AP205 using in vitro and in vivo approaches. The host of this phage is Acinetobacter. The P1 lysis protein targets an essential element for the bacterial survival, the bacterial cell wall. Actually, we hope that knowledge about this protein will contribute to the development of a new class of antibiotics.

Face processing deficits appear early in autism and greatly impact subsequent development. In this paper, the N170 component, an event-related brain potential sensitive to face processing, is examined in children with autism and typical development. The N170 amplitude was sensitive to group differences, as children with typical development showed greater differentiation to upright vs. inverted stimuli and faces vs. vehicles than children with autism. The N170 was also delayed in children with autism. The N170 was not a sensitive marker of individual differences in social behavior and autistic symptomology, but the proceeding positive peak, the P1, was a sensitive marker of individual differences in children with typical development. Results suggest that children with autism and children with typical development employ different face processing strategies, even for the basic encoding of a face.

Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 6 uppsatser.

Diss. (sammanfattning) Stockholm : Karolinska institutet, 2001. / Härtill 5 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

Thesis (Ph. D.)--University of Missouri--Columbia, 2005. / "July 2005." Typescript. Vita. Includes bibliographical references (leaves 196-211). Also issued on the Internet.

Thesis (M.S.)--Massachusetts Institute of Technology. Dept. of Linguistics and Philosophy, 1996. / Cover title. / Includes bibliographical references (p. 68-69). / by Fleur Varaart. / M.S.

Many pathologic lesions and several types of fractures in the equine forelimbs involved the bony elements of the metacarpophalangeal joints (fetlock joints) especially the third metacarpal bones and the proximal sesamoid bones. Although the bones of the fetlock joint have been described in a general manner, the variations between equine breeds are still insufficient and differences within the breeds are not completely covered. Therefore, the aim of the current study was to identify the morphometrical variations of these bones between and within some different equine breeds. / Right and left metacarpal, proximal phalangeal and proximal sesamoid bones were collected from 23 horses (10 Thoroughbreds, 5 Standardbreds and 8 Ponies) euthanized for non-orthopaedic reasons. The bones were boiled between 95°C and 99°C for 30 hours, then cleaned and left for 24 hours at room temperature for air drying. Finally, the bones were dried in the drying cabinet at 49.5°C for 8 hours. A number of dimensional parameters were measured using a custom-built apparatus, calliper and plastic tape. These measurements included proximodistal height, lateromedial width, and dorsopalmar depth. All the statistical data were analysed using the ANOVA test and SPSS statistic software except the repeatability data which were analysed by calculating the repeatability coefficient. / This study showed that there were significant variations between the medial and lateral sides of all bones in all breeds. The length to the lateral condyle of Mc3 was greater than the length to the medial condyle of Mc3 in all breeds. The width and depth of the medial condyle was greater than the lateral condyle in all breeds. The lengths of the lateral sides of the P1 bones were greater than the lengths of the medial sides in the right forelimbs of Thoroughbreds and Standardbreds. The width of the medial articular cavity of P1 was greater than the width of the lateral articular cavity except in the left limb of Ponies. The depth of the medial articular cavity of P1 was greater than the depth of the lateral articular cavity except in the left limb of Standardbreds. The lateral sesamoid bones in both limbs of Thoroughbreds and Ponies were significantly longer or tended to be longer than the medial sesamoid bones. The lateral sesamoid bones were wider than the medial sesamoid bones in both limbs of Ponies. The depths of the lateral sesamoid bones were the significantly greater or tended to be greater than those of the medial sesamoid bones in both limbs of Thoroughbreds and Standardbreds. / There were many morphometrical variations in the bony elements of the equine fetlock joints of Thoroughbreds, Standardbreds and Ponies. Further studies are needed to identify the reasons and mechanical effects of these differences.

Thesis (Ph. D.)--University of Virginia, 1997. / Spine title: Human A2A adenosine receptors. Includes bibliographical references (115-135). Also available online through Digital Dissertations.