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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"p38α MAP kinase."" "subject:"pp38α MAP kinase.""

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Development of a label-free biosensor method for the identification of sticky compounds which disturb GPCR-assays

Mohammed Kader, Hamno January 2013 (has links)
It is widely known that early estimates about the binding properties of drug candidates are important in the drug discovery process. Surface plasmon resonance (SPR) biosensors have become a standard tool for characterizing interactions between a great variety of biomolecules and it offers a unique opportunity to study binding activity. The aim of this project was to develop a SPR based assay for pre-screening of low molecular weight (LMW) drug compounds, to enable filtering away disturbing compounds when interacting with drugs. The interaction between 47 LMW compounds and biological ligands were investigated using the instrument BiacoreTM, which is based on SPR-technology.
Surface plasmon resonance (SPR)
biosensor
Biacore
G-protein-coupled receptors (GPCRs)
Low molecular weight (LMW) compounds
C-C chemokine receptor type 5 (CCR5)
acid-sensing ion channel 1a (ASIC1a)
Thrombin
Carbonic Anhydrase II (CA II)
P38α MAP kinase.

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