Many researchers have documented the trend of decreasing financial support from donors for human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) responses in Ethiopia. Less information is available regarding the correlation between trends of HIV prevalence and external funding and ways to address the impact that funding scarcity could cause. The purpose of this study was to examine the trend of HIV prevalence and donor funding levels, analyzing how the 2 are correlated, and opportunities to improve responses. Using the proximate determinant framework, the research questions examined the changes in HIV prevalence in Ethiopia during the past 10 years; the association between the trends of HIV prevalence, funding levels, and services provided; and the effect of different characteristics on the trend of the prevalence. A paired sample t-test, time series forecasting, Pearson correlation, chi-square test, and multiple regression were employed using a secondary data of sampled 1,067 people from the Demographic and Health Surveys and data from donors. Results indicated that the change in prevalence was statistically significant (t [10] = 4.59, p = .001), and correlated with the funding levels(r (10) = .635*, p = .027), a significant relationship between funding level and type of services, Ï?2 (2, N = 1067) = 1425.7, p <.001 and a significant regression equation to predict HIV prevalence (F (9, 1056) = 12.639, p < .001). The results from this study could be used to inform the Ministry of Health of Ethiopia and HIV project implementers to plan for domestic sustainable financing initiatives, invest based upon evidence-based HIV prevention strategies that could most directly impact quality of life and guide future research.