Discrete event simulation development requires significant investments in time and resources. Descriptions of discrete event simulation models are associated with world views, including the process interaction orientation. Historically, these models have been encoded using high-level programming languages or special purpose, typically vendor-specific, simulation languages. These approaches complicate simulation model reuse and interchange. The current document-centric World Wide Web is evolving into a Semantic Web that communicates information using ontologies. The Web Ontology Language – OWL, was used to encode a Process Interaction Modeling Ontology for Discrete Event Simulations (PIMODES). The PIMODES ontology was developed using ontology engineering processes. Software was developed to demonstrate the feasibility of interchanging models from commercial simulation packages using PIMODES as an intermediate representation. The purpose of PIMODES is to provide a vendor-neutral open representation to support model interchange. Model interchange enables reuse and provides an opportunity to improve simulation quality, reduce development costs, and reduce development times.