Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 6 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.

Thesis (M.D.) -- Dept. of Medicine, University of Adelaide, 1974.

Thesis (M. Res.(Med.))--University of Hong Kong, 2008. / Includes bibliographical references (p. 46-74)

Thesis (Ph. D.)--Case Western Reserve University, 2008. / [School of Medicine] Department of Cell Biology. Includes bibliographical references.

Thesis (doctoral)--Bayerische Ludwig Maximilians Universität, Munich, 1933.

Thesis (Ph.D.)--University of North Carolina at Charlotte, 2005. / Includes bibliographical references (leaves 125-139).

Thesis (Ph.D.)--Aberdeen University, 2008. / Title from web page (viewed on Mar. 2, 2009). Includes bibliographical references.

Thesis (doctoral)--Bayerische Ludwig Maximilians Universität, Munich, 1933.

Made available in DSpace on 2014-06-11T19:27:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2001Bitstream added on 2014-06-13T18:32:16Z : No. of bitstreams: 1 franco_emg_me_botfm.pdf: 1141908 bytes, checksum: 5c0af3cff17baf1fc15b5658534eb386 (MD5) / O objetivo do presente estudo foi analisar plaquetas de pacientes do sexo masculino, portadores de aterosclerose obliterante periférica (GAOP) no estágio de claudicação intermitente, comparando-as com grupo controle de indivíduos normais (GC2) do mesmo sexo e faixa etária. As plaquetas foram estudadas do ponto de vista funcional, através da agregação plaquetária espontânea, e morfológico, através da ultra-estrutura e da morfometria plaquetária. Também foram analisadas plaquetas de indivíduos normais, de faixa etária inferior a 50 anos (GC1), para verificar eventual influência do fator idade na função plaquetária. Para a análise morfológica e morfométrica, sedimentos plaquetários foram processados para microscopia eletrônica de transmissão (MET) e varredura (MEV), segundo técnicas convencionais. Para a prova funcional, o plasma rico em plaquetas foi agitado em agregômetro de plaquetas, sem a adição de agonistas. Todos os indivíduos foram avaliados clínica e laboratorialmente. Com relação à função plaquetária, não houve diferença significativa na agregação plaquetária espontânea, entre os grupos analisados (p>0,05). A morfometria das plaquetas também não acusou diferença na forma das plaquetas, entre os grupos estudados (p>0,05). À MEV, as plaquetas dos indivíduos do grupo GC1 apresentaram freqüência de alterações na forma significativamente maior (42,70±4,54), quando comparadas às dos outros grupos, GC2 (32,31±6,22) e GAOP (37,76±8,91), p>0,05. A dosagem de fibrinogênio do grupo GAOP (262,90±47,86) revelou-se significativamente maior que do grupo GC1 (209,80±47,02), p>0,05; a dosagem de HDL colesterol do grupo GAOP (30,00±5,33) foi significativamente menor que do grupo GC2 (42,70±12,58), p>0,05. Nossos resultados mostram que as plaquetas circulantes dos pacientes portadores de AOP não... / This study aims to analyze the platelets of patients with peripheral obliterative atherosclerosis (POAG), at the intermittent claudication stage and comparing this platelets with the control group of healthy age and sex-matched subjects (CG2). The platelets were studied in relation to: their function, by the spontaneous platelet aggregation, and their morphology, by the platelet ultrastructure and morphometry. We also analyzed the platelets of younger healthy subjects aged less than 50 years (CG1) to find out a probable influence of age factor on platelet function. Morphological and morphometric analyses were performed using platelet pellets processed by transmission electron microscopy (TEM) and scanning electron microscopy (SEM), according to conventional procedures. The functional test was performed using the platelet-rich plasma, mixed in platelet aggregometer without the addition of stimulating agents. All the healthy subjects and patients submitted to clinical and laboratory evaluations. Platelet function did not show significant difference in the studied groups (p>0.05). Platelet morphometry did not show difference in the analysed groups (p.>0.05). The CG1 platelets showed major alteractions in shape (42.70±4.54) than the other groups: CG2 (32.31±6.22) and POAG (37.76±8.91), p>0.05. The POAG fibrinogen determination (262.90±47.86) was significantly higher than CG1 group (209.80±47.02), p>0.05. The POAG HDL determination (30.00±5.33) was significantly higher than CG2 (42.70±12.58), p>0.05. Our results reveal: the POAG circulating platelets do not show functional or morphological alteractions when compared to the age-matched healthy subjects; and the freqüency of circulating platelet with alteractions in shape using SEM preparations were greater in CG1. This suggests an influence of the age factor on function platelet.