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ITC/USA 2011 Conference Proceedings / The Forty-Seventh Annual International Telemetering Conference and Technical Exhibition / October 24-27, 2011 / Bally's Las Vegas, Las Vegas, Nevada / This paper describes a service-based Intelligent Agent (IA) approach for machine learning and data mining of distributed heterogeneous data streams. We focus on an open architecture framework that enables the programmer/analyst to build an IA suite for mining, examining and evaluating heterogeneous data for semantic representations, while iteratively building the probabilistic model in real-time to improve predictability. The Framework facilitates model development and evaluation while delivering the capability to tune machine learning algorithms and models to deliver increasingly favorable scores prior to production deployment. The IA Framework focuses on open standard interoperability, simplifying integration into existing environments.

In the data mining process, it is necessary to prepare the source dataset - for example, to select the cutting or grouping of continuous data attributes etc. and use the knowledge from the problem area. Such a preparation process can be guided by background (domain) knowledge obtained from experts. In the SEWEBAR project, we collect the knowledge from experts in a rich XML-based representation language, called BKEF, using a dedicated editor, and save into the database of our custom-tailored (Joomla!-based) CMS system. Data mining tools are then able to generate, from this dataset, mining models represented in the standardized PMML format. It is then necessary to map a particular column (attribute) from the dataset (in PMML) to a relevant 'metaattribute' of the BKEF representation. This specific type of schema mapping problem is addressed in my thesis in terms of algorithms for automatic suggestion of mapping of columns to metaattributes and from values of these columns to BKEF 'metafields'. Manual corrections of this mapping by the user are also supported. The implementation is based on the PHP language and then it was tested on datasets with information about courses taught in 5 universities in the U.S.A. from Illinois Semantic Integration Archive. On this datasets, the auto-mapping suggestion process archieved the precision about 70% and recall about 77% on unknown columns, but when mapping the previously user-mapped data (using implemented learning module), the recall is between 90% and 100%.

Indiana University-Purdue University Indianapolis (IUPUI) / Precision medicine refers to the delivering of customized treatment to patients based on their individual characteristics, and aims to reduce adverse events, improve diagnostic methods, and enhance the efficacy of therapies. Among efforts to achieve the goals of precision medicine, researchers have used observational data for developing predictive modeling to best predict health outcomes according to patients’ variables. Although numerous predictive models have been reported in the literature, not all models present high prediction power, and as the result, not all models may reach clinical settings to help healthcare professionals make clinical decisions at the point-of-care. The lack of generalizability stems from the fact that no comprehensive medical data repository exists that has the information of all patients in the target population. Even if the patients’ records were available from other sources, the datasets may need further processing prior to data analysis due to differences in the structure of databases and the coding systems used to record concepts. This project intends to fill the gap by introducing an interoperable solution that receives patient electronic health records via Health Level Seven (HL7) messaging standard from other data sources, transforms the records to observational medical outcomes partnership (OMOP) common data model (CDM) for population health research, and applies predictive models on patient data to make predictions about health outcomes. This project comprises of three studies. The first study introduces CCD-TOOMOP parser, and evaluates OMOP CDM to accommodate patient data transferred by HL7 consolidated continuity of care documents (CCDs). The second study explores how to adopt predictive model markup language (PMML) for standardizing dissemination of OMOP-based predictive models. Finally, the third study introduces Personalized Health Risk Scoring Tool (PHRST), a pilot, interoperable OMOP-based model scoring tool that processes the embedded models and generates risk scores in a real-time manner. The final product addresses objectives of precision medicine, and has the potentials to not only be employed at the point-of-care to deliver individualized treatment to patients, but also can contribute to health outcome research by easing collecting clinical outcomes across diverse medical centers independent of system specifications.