<p>It is well established that cochlear implants (CIs) are able to provide many users with excellent speech recognition ability in quiet conditions; however, the ability to correctly identify speech in noisy conditions or appreciate music is generally poor for implant users with respect to normal-hearing listeners. This discrepancy has been hypothesized to be in part a function of the relative decrease in spectral information available to implant users (Rubinstein and Turner, 2003; Wilson et al., 2004). One method that has been proposed for increasing the amount of spectral information available to CI users is to include time-varying stimulation rate in addition to changes in the place of stimulation. However, previous implementations of multi-rate strategies have failed to result in an improvement in speech recognition over the clinically available, fixed-rate strategies (Fearn, 2001; Nobbe, 2004). It has been hypothesized that this lack of success was due to a failure to consider the underlying perceptual responses to multi-rate stimulation. </p><p>In this work, psychophysical experiments were implemented with the goal of achieving a better understanding of the interaction of place and rate of stimulation and the effects of duration and context on CI listeners' ability to detect changes in stimulation rate. Results from those experiments were utilized in the implementation of a tuned multi-rate sound processing strategy for implant users in order to potentially ``tune" multi-rate strategies and improve speech recognition performance. </p><p>In an acute study with quiet conditions, speech recognition performance with a tuned multi-rate implementation was better than performance with a clinically available, fixed-rate strategy, although the difference was not statistically significant. These results suggest that utilizing time-varying pulse rates in a subject-specific implementation of a multi-rate algorithm may offer improvements in speech recognition over clinically available strategies. A longitudinal study was also performed to investigate the potential benefit from training to speech recognition. General improvements in speech recognition ability were observed as a function of time; however, final scores with the tuned multi-rate algorithm never surpassed performance with the fixed-rate algorithm for noisy conditions. </p><p>The ability to improve upon speech recognition scores for quiet conditions with respect to the fixed-rate algorithm suggests that using time-varying stimulation rates potentially provides additional, usable information to listeners. However, performance with the fixed-rate algorithm proved to be more robust to noise, even after three weeks of training. This lack of robustness to noise may be in part a result of the frequency estimation technique used in the multi-rate strategy, and thus more sophisticated techniques for real-time frequency estimation should be explored in the future.</p> / Dissertation

Researchers previously have found a correlation between the strength of the auditory steady-state response (ASSR) and corresponding auditory behavioral measurements such as speech recognition scores, thus concluding that the ASSR can be used as an objective measurement of auditory supra-threshold properties. In the present study, it was hypothesized that the increase in the strength of the ASSR at different modulation depths would be reflected in corresponding psychophysical measures, specifically, auditory modulation discrimination. These relationships were investigated in normally-hearing listeners at modulation rates of 40 and 80 Hz for both amplitude (AM) and mixed modulation (MM), at several modulation depths. Analyses were completed for two sets of measurements derived from the physiological and behavioral responses. For the first analysis, derived measures of iso-neurometric thresholds were compared to isometric modulation discrimination thresholds. For the second analysis, derived estimates of physiological neurometric slope were compared to estimated psychometric function slopes. Mixed-model analyses for both of these measures revealed significant or near-significant relationships between physiological and psychophysical measures at 40 Hz for AM and at 80 Hz for MM. Bootstrap resampling analyses were completed to estimate the distribution of the resultant statistics. Implications regarding the location of neural encoding for amplitude and frequency modulation were discussed. / text

Visual memory holds in mind details of objects, textures, faces, and scenes. After initial exposure to an image, however, visual memories rapidly degrade because they are transferred from iconic memory, a high-capacity sensory buffer, to working memory, a low-capacity maintenance system. How does visual memory maintenance work? This dissertation builds the argument that the maintenance of short-term visual memories is analogous to the act of breathing: it is a dynamic process with a default behavior that explains much of its usual workings, but which can be observed, overridden, and controlled. Chapter 1 shows how the act of trying to remember more information causes people to forget faster and to remember less ("load-dependent forgetting" and "overreaching"). It then shows how the paradigm of evolution can be applied to the problem of maintenance, with memories competing over a limited memory-supporting commodity, explaining these effects. Chapter 2 presents experiments on metamemory, the ability of people to observe and make decisions about their own memories. The experiments isolate a component of metamemory that monitors a memory's quality as it degrades over time. Chapter 3 connects memory to metamemory, drawing on work from reinforcement learning and decision theory to liken the problem of memory maintenance to that of an agent who sequentially decides what to prioritize in a partially observable mind. / Psychology

The most accepted model of mammalian binaural sound localization postulates two neural/perceptual channels with hemifield tuning and overlapping medial borders; the extent to which the two channels are co-activated by the source is the neural "code" for the source's azimuthal location. This model does not take into account physiological data on the existence of a population of cells with spatial receptive fields centered on the azimuthal midline. The following work sought to test the hypothesis that the mammalian binaural sound localization apparatus includes a third, midline-tuned channel. Ten experiments used a selective adaptation paradigm in human listeners to probe for the existence of a midline channel. Psychometric functions were obtained for lateral position based on ITD or ILD both before and after adaptation with high-frequency (2800 and 4200 Hz) or low-frequency (260 and 570 Hz) tones. Listeners experienced highly lateralized adaptor stimuli with different frequencies at each ear (asymmetrical adaptation), highly lateralized adaptor stimuli of the same frequency at each ear (symmetrical adaptation), and single frequency adaptation at the midline (central adaptation). At both high and low frequencies in the domains of both interaural time difference (ITD) and interaural level difference (ILD), location judgements after asymmetrical adaptation shifted away from the fatigued side. These shifts occurred across each adapted hemifield and extended slightly over the midline, as is consistent with the two-channel model. The two-channel model would predict no effect of symmetrical or central adaptation because fatiguing both lateral channels equally would not change their relative activation by a given source. In practice, the result of symmetrical adaptation was a shift in location judgements towards the midline as would be expected if adaptation of the lateral channels resulted in a greater relative contribution of a third, midline channel. Likewise, central adaptation tended to result in shifts in perceived location towards the sides. The evidence for the midline channel was strong for high and low frequencies localized by ILD, and was present for low frequencies, but not for high frequencies, localized by ITD.

Behavioural phonotaxis (oriented movement in response to sound) is an effective means to quantify auditory perception in acoustically communicating insects. Previous phonotaxis studies on the acoustic parasitoid fly Ormia ochracea (Diptera: Tachinidae) have described stereotyped, reflex-like responses towards auditory stimuli modeled after their preferred cricket hosts, yet their ability to demonstrate plasticity of responses in the context of dynamically changing auditory cues has not previously been described. Using a behavioural sensitization protocol, I compared phonotaxis towards behaviourally irrelevant (non-attractive) test stimuli presented alone, and when preceded with the natural, response-evoking cricket song (attractive). Results demonstrate the cricket song as a sensitizing stimulus mediating phonotaxis towards otherwise non-attractive sounds, and differential walking patterns depending on temporal delay between song offset and test stimulus onset. My findings suggest an ecological purpose of sensitization, allowing flies to maintain orientation towards a cricket host amidst conditions of signal disruption in the environment.

Behavioural phonotaxis (oriented movement in response to sound) is an effective means to quantify auditory perception in acoustically communicating insects. Previous phonotaxis studies on the acoustic parasitoid fly Ormia ochracea (Diptera: Tachinidae) have described stereotyped, reflex-like responses towards auditory stimuli modeled after their preferred cricket hosts, yet their ability to demonstrate plasticity of responses in the context of dynamically changing auditory cues has not previously been described. Using a behavioural sensitization protocol, I compared phonotaxis towards behaviourally irrelevant (non-attractive) test stimuli presented alone, and when preceded with the natural, response-evoking cricket song (attractive). Results demonstrate the cricket song as a sensitizing stimulus mediating phonotaxis towards otherwise non-attractive sounds, and differential walking patterns depending on temporal delay between song offset and test stimulus onset. My findings suggest an ecological purpose of sensitization, allowing flies to maintain orientation towards a cricket host amidst conditions of signal disruption in the environment.

<p>Cochlear implant listeners are presented with a time and frequency-quantized version of speech signals. In the frequency domain, resolution is limited by the number of electrodes in each listener's array. Current cochlear implant speech processing strategies implicitly assume that the information presented to each one of these electrodes is perceived as unique and independent. However, previous research suggests that stimuli presented on different electrodes can be indiscriminable (e.g. Zwolan et al., 1997; Throckmorton and Collins, 1999; Henry et al., 2000) . Additional studies suggest that stimuli presented on one electrode can influence the perception of stimuli on neighboring electrodes (e.g. Shannon, 1990; Chatterjee and Shannon, 1998; Boëx et al., 2003). Removing this redundant or occluded information could cause more distinct or perceivable information to be presented to the listener and possibly result in improved speech recognition.</p><p>Previous studies have used psychophysical data to identify the electrodes with the highest potential to confound speech recognition (Zwolan et al., 1997, Boëx et al., 2003, and Garadat et al., 2012). In order to minimize electrode interactions and maximize the amount of perceivable information, each of these studies used a single psychophysical metric to deactivate the electrodes across all time windows of the speech processing strategy. For some listeners, these reduced electrode sets resulted in improved speech recognition over using the of the electrodes in their array. These studies did not compare the results of using different psychophysical metrics to exclude electrodes for a group of listeners nor did they investigate speech recognition performance as a function of the number of electrodes excluded from the array.</p><p>In this work, three different psychophysical metrics were used to obtain a multidimensional estimate of the potential "usefulness'' of each electrode. These results were then used to inform two different methods of psychophysics-motivated electrode selection. The first method incorporated individual data into each listener's energy-driven speech processing strategy. For each time window, the electrodes with the highest energy that were also most likely to be perceived, according to the psychophysical data, were selected for stimulation. The second method sequentially excluded the electrodes with the highest potential to confound from the array across all time windows, resulting in a group of psychophysics-motivated electrode sets for each metric. Evaluating each of these electrode sets exhaustively would require a prohibitive amount of experimental time. To mitigate this problem, an adaptive procedure was developed to estimate performance as a function of cochlear implant parameters in a time-efficient manner. For each metric, the procedure estimated the set with the highest estimated probability of correct phoneme identification. Listeners' speech recognition performance using this electrode set was then compared to their performance using their full electrode array. For both electrode selection methods, listeners' speech recognition scores were generally comparable to those obtained in the clinical condition. This finding supports the hypothesis that listeners were not perceiving all the information presented to them using their clinical speech processing strategy and their complete set of electrodes. Additionally, these results suggest that improvements to the proposed electrode selection strategies should be in investigated in order to increase the amount of perceivable information presented to cochlear implant listeners.</p> / Dissertation

No description available.

No description available.

Thesis (Ph.D.). / Written for the Dept. of Ophthalmology, Neurology and Neurosurgery. Title from title page of PDF (viewed 2008/03/12). Includes bibliographical references.