Meng, Zhaoyu. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2010. / Includes bibliographical references (leaves 61-74). / Abstracts in English and Chinese. / Declaration of Origination --- p.II / Abstract --- p.III / Acknowledgement --- p.VII / Table of Contents --- p.VIII / List of Tables --- p.XI / List of Figures --- p.XII / List of Abbreviations --- p.XIII / Chapter Chapter 1. --- Review of postoperative pain --- p.1 / Chapter Chapter 2. --- Candidate Genes --- p.6 / Chapter 2.1 --- μ Opioid Receptor Gene --- p.6 / Chapter 2.2 --- ATP-binding cassette B1 (ABCB1) / multiple drug resistance 1 (MDR1) gene --- p.10 / Chapter 2.3 --- Catechol-O-methyltransferase (COMT) gene --- p.10 / Chapter 2.4 --- βArrestin2 gene --- p.11 / Chapter 2.5 --- Transient receptor potential (TRP) gene --- p.11 / Chapter 2.6 --- GTP cyclohydrolase 1 (GCHl)gene --- p.12 / Chapter Chapter 3. --- Hypothesis and Experimental Design --- p.15 / Chapter 3.1 --- Hypothesis --- p.15 / Chapter 3.2 --- Objectives --- p.15 / Chapter 3.3 --- Experimental design --- p.15 / Chapter 4.4 --- Role in this study --- p.16 / Chapter Chapter 4. --- Methods --- p.17 / Chapter 4.1 --- Patients --- p.17 / Chapter 4.2 --- Anesthetic procedure --- p.17 / Chapter 4.3 --- Postoperative management --- p.18 / Chapter 4.4 --- Patient follow-up --- p.19 / Chapter 4.5 --- Definition of endpoints --- p.19 / Chapter Chapter 5. --- Genotyping --- p.22 / Chapter Chapter 6 --- Statistical Analysis and Sample Size --- p.24 / Chapter 6.1 --- Statistical analysis --- p.24 / Chapter 6.2 --- Sample size --- p.26 / Chapter Chapter 7. --- "Demographic, genotype and haplotype result" --- p.28 / Chapter 7.1 --- Patient characteristics --- p.28 / Chapter 7.2 --- Genotypes and haplotypes --- p.30 / Chapter Chapter 8. --- Acute postoperative pain --- p.35 / Chapter Chapter 9. --- Morphine consumption for early postoperative pain --- p.41 / Chapter 9.1 --- Patients using alternative analgesia --- p.41 / Chapter 9.2 --- Result in the patients using morphine alone --- p.41 / Chapter Chapter 10. --- Opioid-related Side Effects --- p.47 / Chapter Chapter 11. --- Chronic postoperative pain --- p.49 / Chapter 11.1 --- Patient characteristics --- p.49 / Chapter 11.2 --- Association of genetic polymorphisms and Chronic postoperative pain --- p.51 / Chapter Chapter 12. --- Discussion --- p.54 / Chapter 12.1 --- Acute postoperative pain --- p.54 / Chapter 12.2 --- Chronic postoperative pain --- p.57 / Chapter Chapter 13. --- Conclusion --- p.60 / References --- p.61 / Appendix I. Morphine Consumption and and Number of Demands for Patient Controlled Analgesia (PCA) in Patients with Different Genotypes --- p.75 / Appendix II. Opioid Related Symptom Distress Scale Score on Day 1 and Overall Score of Each Day in Patients with Different Genotypes --- p.79 / Appendix III. Opioid Related Symptoms Distress Scale Score in Patients with Different Genotypes --- p.83